{"id":22794,"date":"2018-01-26T00:31:33","date_gmt":"2018-01-26T00:31:33","guid":{"rendered":"http:\/\/www.fjala.info\/?p=22794"},"modified":"2020-04-08T14:54:05","modified_gmt":"2020-04-08T13:54:05","slug":"si-ka-filluar-jeta-ne-toke","status":"publish","type":"post","link":"https:\/\/jehonashqiptare.al\/fjala\/si-ka-filluar-jeta-ne-toke\/","title":{"rendered":"SI KA FILLUAR JETA N\u00cb TOK\u00cb? &#8211; nj\u00eb artikull i BBC b\u00ebn sqarimin shkencor"},"content":{"rendered":"<p>Nga\u00a0<strong>Michael Marshall<\/strong>, <em>31 tetor 2016<\/em><\/p>\n<blockquote>\n<p style=\"text-align: center;\"><em>P\u00ebrktheu dhe p\u00ebrgatiti n\u00eb shqip, <strong>Arben \u00c7okaj<\/strong><\/em><\/p>\n<\/blockquote>\n<p><strong><em>Kjo histori \u00ebsht\u00eb pjes\u00eb e list\u00ebs s\u00eb BBC p\u00ebr Tok\u00ebn &#8220;M\u00eb e mira p\u00ebr<\/em><\/strong><strong><em>\u00a02016&#8243;, rezultati m\u00eb i madh i vitit. <a href=\"http:\/\/www.bbc.com\/earth\/story\/20161219-here-are-bbc-earths-ten-best-stories-of-2016\" target=\"_blank\" rel=\"noopener noreferrer\">Shfletoni list\u00ebn e plot\u00eb.<\/a><\/em><\/strong> <em>(n\u00eb anglisht)<\/em><\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Rotomahana\" src=\"http:\/\/fjala.info\/2018\/p03scq93.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Charles Blomfield &#8220;Tarracat e bardha, Rotomahana&#8221; (1897)<\/em><br \/>\n(Credit: PAINTING\/Alamy Stock Photo)<\/p>\n<\/blockquote>\n<p>Si filloi jeta n\u00eb tok\u00eb? Nuk mund t\u00eb ket\u00eb nj\u00eb pyetje m\u00eb t\u00eb madhe. P\u00ebr pjes\u00ebn m\u00eb t\u00eb madhe t\u00eb historis\u00eb njer\u00ebzore, pothuajse t\u00eb gjith\u00eb besonin se nj\u00eb version i &#8220;per\u00ebndive e b\u00ebri k\u00ebt\u00eb&#8221;. \u00c7do shpjegim tjet\u00ebr ishte i pakonceptuesh\u00ebm.<\/p>\n<p><strong>Kjo nuk \u00ebsht\u00eb m\u00eb e v\u00ebrtet\u00eb<\/strong>. Gjat\u00eb shekullit t\u00eb kaluar, disa shkenc\u00ebtar\u00eb jan\u00eb p\u00ebrpjekur t\u00eb kuptojn\u00eb se si mund t\u00eb ket\u00eb dal\u00eb jeta e par\u00eb. Ata madje u p\u00ebrpoq\u00ebn t\u00eb rikrijojn\u00eb k\u00ebt\u00eb moment Zanafille n\u00eb laborator\u00ebt e tyre: t\u00eb krijojn\u00eb nj\u00eb jet\u00eb krejt t\u00eb re nga e para.<\/p>\n<p>Deri m\u00eb tani askush nuk e kan\u00eb arritur at\u00eb, por kemi arritur nj\u00eb rrug\u00eb t\u00eb gjat\u00eb. Sot, shum\u00eb nga shkenc\u00ebtar\u00ebt q\u00eb studiojn\u00eb origjin\u00ebn e jet\u00ebs jan\u00eb t\u00eb bindur se jan\u00eb n\u00eb rrug\u00ebn e duhur &#8211; dhe kan\u00eb eksperimente p\u00ebr ta mb\u00ebshtetur besimin e tyre.<\/p>\n<p>Kjo \u00ebsht\u00eb historia e p\u00ebrpjekjes son\u00eb p\u00ebr t\u00eb zbuluar origjin\u00ebn ton\u00eb t\u00eb fundit. Kjo \u00ebsht\u00eb nj\u00eb histori e obsesionit, luft\u00ebs dhe krijimtaris\u00eb s\u00eb shk\u00eblqyer, e cila p\u00ebrfshin disa nga zbulimet m\u00eb t\u00eb m\u00ebdha t\u00eb shkenc\u00ebs moderne. P\u00ebrpjekja p\u00ebr t\u00eb kuptuar fillimet e jet\u00ebs ka d\u00ebrguar burra dhe gra n\u00eb skajet m\u00eb t\u00eb larg\u00ebta t\u00eb planetit ton\u00eb. Disa nga shkenc\u00ebtar\u00ebt e p\u00ebrfshir\u00eb jan\u00eb shtangur si p\u00ebrbind\u00ebsha, nd\u00ebrsa t\u00eb tjer\u00ebt duhej t\u00eb b\u00ebnin pun\u00ebn e tyre n\u00ebn thembra t\u00eb qeverive brutale totalitare.<\/p>\n<p>Kjo \u00ebsht\u00eb historia e lindjes s\u00eb jet\u00ebs n\u00eb Tok\u00eb.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Skelet dinosauri\" src=\"http:\/\/fjala.info\/2018\/p04dbtkn.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Dinosaur\u00ebt jetuan aktualisht mjaft koh\u00eb m\u00eb par\u00eb<\/em> (Credit: Oleksiy Maksymenko\/Alamy)<\/p>\n<\/blockquote>\n<p>Jeta \u00ebsht\u00eb e vjet\u00ebr. Dinosaur\u00ebt ndoshta jan\u00eb krijesat m\u00eb t\u00eb njohura t\u00eb zhdukura dhe fillimet e tyre kan\u00eb qen\u00eb 250 milion\u00eb vjet m\u00eb par\u00eb. Por jeta daton shum\u00eb m\u00eb tej.<\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0301926807001234?via%3Dihub\" target=\"_blank\" rel=\"noopener noreferrer\">Fosilet m\u00eb t\u00eb vjet\u00ebr<\/a> t\u00eb njohur jan\u00eb rreth 3.5 miliard\u00eb vje\u00e7, 14 her\u00eb m\u00eb t\u00eb vjet\u00ebr se dinosaur\u00ebt m\u00eb t\u00eb vjet\u00ebr. Por t\u00eb dh\u00ebnat fosile mund t\u00eb shtrihen p\u00ebrs\u00ebri m\u00eb tej. P\u00ebr shembull, n\u00eb gusht t\u00eb vitit 2016, hulumtuesit gjet\u00ebn ato q\u00eb duket t\u00eb jen\u00eb <a href=\"https:\/\/www.nature.com\/articles\/nature19355\" target=\"_blank\" rel=\"noopener noreferrer\">fosile t\u00eb fosilizuara<\/a> q\u00eb datojn\u00eb <a href=\"http:\/\/www.bbc.com\/news\/science-environment-37235447\" target=\"_blank\" rel=\"noopener noreferrer\">3.7 miliard\u00eb vjet<\/a> m\u00eb par\u00eb.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><a href=\"http:\/\/fjala.info\/2018\/p04ddzqq.jpg\"><img decoding=\"async\" class=\"aligncenter\" title=\"Modele t\u00eb val\u00ebzuara fosilesh\" src=\"http:\/\/fjala.info\/2018\/p04ddzqq.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><\/a><em>K\u00ebto modele t\u00eb val\u00ebzuara mund t\u00eb jen\u00eb fosile 3.7 miliard\u00eb vje\u00e7are<\/em><br \/>\n(Credit: Nutman et al, Nature)<\/p>\n<\/blockquote>\n<p>Vet\u00eb Toka nuk \u00ebsht\u00eb shum\u00eb m\u00eb e vjet\u00ebr, duke u formuar 4.5 miliard vjet m\u00eb par\u00eb.<\/p>\n<p>N\u00ebse supozojm\u00eb se jeta e formuar n\u00eb Tok\u00eb &#8211; e cila duket e arsyeshme, duke pasur parasysh se <a href=\"http:\/\/www.bbc.com\/earth\/story\/20150429-will-we-find-aliens\" target=\"_blank\" rel=\"noopener noreferrer\">nuk e kemi gjetur akoma diku tjet\u00ebr<\/a> &#8211; at\u00ebher\u00eb duhet t\u00eb ket\u00eb b\u00ebr\u00eb k\u00ebshtu n\u00eb miliarda vjet midis Tok\u00ebs q\u00eb po lindte dhe ruajtjes s\u00eb fosileve m\u00eb t\u00eb vjetra t\u00eb njohura.<\/p>\n<p>Si dhe duke u fokusuar kur filloi jeta, ne mund t\u00eb arrijm\u00eb n\u00eb nj\u00eb mendim t\u00eb arsimuar, n\u00eb at\u00eb q\u00eb ishte.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Pema e jet\u00ebs\" src=\"http:\/\/fjala.info\/2018\/p04cl3wf.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Pema e jet\u00ebs: shumica e deg\u00ebve jan\u00eb baktere<br \/>\n<\/em>(Credit: Hug, Banfield et al, Nature Microbiology)<\/p>\n<\/blockquote>\n<p>Q\u00eb nga shekulli i 19-t\u00eb, biolog\u00ebt kan\u00eb njohur se t\u00eb gjitha gjallesat jan\u00eb b\u00ebr\u00eb nga &#8220;qelizat&#8221;: \u00e7anta t\u00eb vogla t\u00eb materialit t\u00eb gjall\u00eb, q\u00eb vijn\u00eb n\u00eb forma dhe madh\u00ebsi t\u00eb ndryshme. Qelizat u zbuluan s\u00eb pari n\u00eb shekullin e 17-t\u00eb, kur u zbuluan mikroskop\u00ebt e par\u00eb modern\u00eb, por u desh m\u00eb shum\u00eb se nj\u00eb shekull p\u00ebr t\u00eb kuptuar se ata ishin baza e gjith\u00eb jet\u00ebs.<\/p>\n<blockquote><p><em>Duke p\u00ebrdorur vet\u00ebm materialet dhe kushtet e gjetura n\u00eb Tok\u00eb mbi 3.5 miliard vjet m\u00eb par\u00eb, ne duhet t\u00eb b\u00ebjm\u00eb nj\u00eb qeliz\u00eb<\/em><\/p><\/blockquote>\n<p>Ju nuk mund t\u00eb mendoni se ju duken shum\u00eb si nj\u00eb mustak ose nj\u00eb rex Tyrannosaurus, por nj\u00eb mikroskop do t\u00eb zbuloj\u00eb se t\u00eb gjith\u00eb ju jeni b\u00ebr\u00eb nga qeliza mjaft t\u00eb ngjashme. K\u00ebshtu jan\u00eb edhe bim\u00ebt dhe k\u00ebrpudhat.<\/p>\n<p>Por, deri tani, format m\u00eb t\u00eb shumta t\u00eb jet\u00ebs jan\u00eb mikroorganizmat, secila prej t\u00eb cilave p\u00ebrb\u00ebhet nga vet\u00ebm nj\u00eb qeliz\u00eb. Bakteret jan\u00eb grupi m\u00eb i famsh\u00ebm dhe gjenden kudo n\u00eb Tok\u00eb.<\/p>\n<p>N\u00eb prill t\u00eb vitit 2016, shkenc\u00ebtar\u00ebt paraqit\u00ebn nj\u00eb <a href=\"https:\/\/www.nature.com\/articles\/nmicrobiol201648\" target=\"_blank\" rel=\"noopener noreferrer\">version t\u00eb p\u00ebrdit\u00ebsuar t\u00eb &#8220;pem\u00ebs s\u00eb jet\u00ebs&#8221;<\/a>: nj\u00eb lloj peme familjare p\u00ebr \u00e7do specie t\u00eb gjall\u00eb. Pothuajse t\u00eb gjitha deg\u00ebt jan\u00eb baktere. P\u00ebr m\u00eb tep\u00ebr, forma e pem\u00ebs sugjeron se nj\u00eb bakter \u00ebsht\u00eb paraardh\u00ebsi i p\u00ebrbashk\u00ebt i t\u00eb gjith\u00eb jet\u00ebs. Me fjal\u00eb t\u00eb tjera, \u00e7do gj\u00eb e gjall\u00eb &#8211; p\u00ebrfshir\u00eb edhe ju &#8211; p\u00ebrfundimisht zbritet te nj\u00eb bakter.<\/p>\n<p>Kjo do t\u00eb thot\u00eb q\u00eb ne mund ta p\u00ebrcaktojm\u00eb m\u00eb sakt\u00eb problemin e origjin\u00ebs s\u00eb jet\u00ebs. Duke p\u00ebrdorur vet\u00ebm materialet dhe kushtet e gjetura n\u00eb Tok\u00eb mbi 3.5 miliard vjet m\u00eb par\u00eb, ne duhet t\u00eb b\u00ebjm\u00eb nj\u00eb qeliz\u00eb.<\/p>\n<p>Epo, sa e v\u00ebshtir\u00eb mund t\u00eb jet\u00eb?<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Pema e jet\u00ebs\" src=\"http:\/\/fjala.info\/2018\/p04clbmb.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Nj\u00eb qeliz\u00eb e plot\u00eb, e gjall\u00eb (Credit: Equinox Graphics Ltd)<\/em><\/p>\n<\/blockquote>\n<p><strong>Kapitulli 1. Eksperimentet e para<\/strong><\/p>\n<p>P\u00ebr pjes\u00ebn m\u00eb t\u00eb madhe t\u00eb historis\u00eb, nuk konsiderohej me t\u00eb v\u00ebrtet\u00eb e nevojshme p\u00ebr t\u00eb pyetur se si filloi jeta, sepse p\u00ebrgjigja dukej e dukshme.<\/p>\n<p>Para viteve 1800, shumica e njer\u00ebzve besonin n\u00eb &#8220;vitalizmin&#8221;. Kjo \u00ebsht\u00eb ideja intuitive se gj\u00ebrat e gjalla ishin t\u00eb pajisura me nj\u00eb pasuri t\u00eb ve\u00e7ant\u00eb magjike, q\u00eb i b\u00ebnte ata t\u00eb ndrysh\u00ebm nga sendet e pajet\u00eb.<\/p>\n<blockquote><p><em>Kimikatet e jet\u00ebs mund t\u00eb b\u00ebhen t\u00eb gjitha nga kimikate m\u00eb t\u00eb thjeshta q\u00eb nuk kan\u00eb t\u00eb b\u00ebjn\u00eb me jet\u00ebn<\/em><\/p><\/blockquote>\n<p>Vitalizmi shpesh lidhej me besimet fetare t\u00eb \u00e7muara. Bibla thot\u00eb se Per\u00ebndia p\u00ebrdori \u00ab<a href=\"https:\/\/www.kingjamesbibleonline.org\/Genesis-2-7\/\" target=\"_blank\" rel=\"noopener noreferrer\">frym\u00ebn e jet\u00ebs<\/a>\u00bb p\u00ebr t\u00eb animuar njer\u00ebzit e par\u00eb dhe shpirti i pavdeksh\u00ebm \u00ebsht\u00eb nj\u00eb form\u00eb vitalizmi.<\/p>\n<p>Ekziston vet\u00ebm nj\u00eb problem. Vitalizmi \u00ebsht\u00eb i gabuar.<\/p>\n<p>Deri n\u00eb fillim t\u00eb viteve 1800, shkenc\u00ebtar\u00ebt kishin zbuluar disa substanca, q\u00eb dukeshin t\u00eb jen\u00eb unike p\u00ebr jet\u00ebn. Nj\u00eb kimik i till\u00eb ishte ure, e cila gjendet n\u00eb urin\u00eb dhe u izolua n\u00eb 1799.<\/p>\n<p>Kjo ishte akoma, e drejt\u00eb, e pajtueshme me vitalizmin. Vet\u00ebm gj\u00ebrat e gjalla dukeshin t\u00eb jen\u00eb n\u00eb gjendje t&#8217;i b\u00ebjn\u00eb k\u00ebto kimikate, k\u00ebshtu q\u00eb ndoshta ata ishin t\u00eb mbushur me energji jet\u00ebsore dhe kjo ishte ajo q\u00eb i b\u00ebri ata t\u00eb ve\u00e7ant\u00eb.<\/p>\n<p>Por n\u00eb 1828, kimisti gjerman <strong>Friedrich W\u00f6hler<\/strong> gjeti <a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/andp.18280880206\/epdf?r3_referer=wol&amp;tracking_action=preview_click&amp;show_checkout=1&amp;purchase_referrer=www.bbc.com&amp;purchase_site_license=LICENSE_DENIED\" target=\"_blank\" rel=\"noopener noreferrer\">nj\u00eb m\u00ebnyr\u00eb p\u00ebr t\u00eb b\u00ebr\u00eb ure nga nj\u00eb kombinim kimik i zakonsh\u00ebm i quajtur cianati i amoniakut<\/a>, i cili nuk kishte lidhje t\u00eb dukshme me gjallesat. T\u00eb tjer\u00eb e ndoq\u00ebn gjurm\u00ebt e tij dhe shpejt u zbulua se kimikatet e jet\u00ebs mund t\u00eb b\u00ebhen t\u00eb gjitha nga kimikate m\u00eb t\u00eb thjeshta, q\u00eb nuk kan\u00eb t\u00eb b\u00ebjn\u00eb me jet\u00ebn.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Kimisti gjerman Friedrich W\u00f6hler\" src=\"http:\/\/fjala.info\/2018\/p04d7cft.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Kimisti gjerman Friedrich W\u00f6hler, n\u00eb nj\u00eb litografi nga Rudolf Hoffmann m\u00eb 1856<\/em><\/p>\n<\/blockquote>\n<p>Ky ishte fundi i vitalizmit si nj\u00eb koncept shkencor. Por njer\u00ebzit e gjet\u00ebn at\u00eb thell\u00ebsisht t\u00eb v\u00ebshtir\u00eb p\u00ebr t&#8217;u larguar nga ideja. P\u00ebr shum\u00eb njer\u00ebz, duke th\u00ebn\u00eb se nuk ka asgj\u00eb &#8220;t\u00eb ve\u00e7ant\u00eb&#8221; n\u00eb lidhje me kimikatet e jet\u00ebs dukej se vjedh jet\u00ebn e magjis\u00eb s\u00eb saj, p\u00ebr t\u00eb na zvog\u00ebluar n\u00eb makina t\u00eb thjeshta. Gjithashtu, natyrisht, kjo kund\u00ebrshtoi edhe Bibl\u00ebn.<\/p>\n<blockquote><p><em>Misteri i origjin\u00ebs s\u00eb jet\u00ebs \u00ebsht\u00eb injoruar p\u00ebr dekada t\u00eb t\u00ebra<\/em><\/p><\/blockquote>\n<p>Edhe shkenc\u00ebtar\u00ebt kan\u00eb luftuar p\u00ebr t\u00eb hequr vitalizmin. Deri n\u00eb vitin 1913, biokimisti anglez <strong>Benjamin Moore<\/strong> po nxiste me zell nj\u00eb teori t\u00eb &#8220;<a href=\"http:\/\/www.readbookonline.net\/readOnLine\/20877\/\" target=\"_blank\" rel=\"noopener noreferrer\">energjis\u00eb biotike<\/a>&#8220;, e cila ishte n\u00eb thelb vitaliz\u00ebm n\u00ebn nj\u00eb em\u00ebr tjet\u00ebr. Ideja kishte nj\u00eb mb\u00ebrthim t\u00eb fort\u00eb emocional.<\/p>\n<p>Sot ideja ngjitet n\u00eb vende t\u00eb papritura. P\u00ebr shembull, ka shum\u00eb tregime shkencore-fiction n\u00eb t\u00eb cilat &#8220;energjia e jet\u00ebs&#8221; e nj\u00eb personi mund t\u00eb rritet ose t\u00eb largohet. Mendoni p\u00ebr &#8220;energjin\u00eb e rigjenerimit&#8221; q\u00eb p\u00ebrdoret nga Zot\u00ebruesit e Koh\u00ebs n\u00eb <em>Doctor Who<\/em>, e cila madje <a href=\"http:\/\/tardis.wikia.com\/wiki\/The_Time_of_the_Doctor_%28TV_story%29\" target=\"_blank\" rel=\"noopener noreferrer\">mund t\u00eb ngrihet n\u00eb qoft\u00eb se shkon ul\u00ebt<\/a>. Kjo ndjehet futuriste, por \u00ebsht\u00eb nj\u00eb ide e mod\u00ebs s\u00eb vjet\u00ebr.<\/p>\n<p>Sidoqoft\u00eb, pas 1828, shkenc\u00ebtar\u00ebt kishin arsye legjitime t\u00eb k\u00ebrkonin nj\u00eb shpjegim jo-hyjnor se si u krijua jeta e par\u00eb. Por ata nuk e b\u00ebn\u00eb. Duket sikur nj\u00eb subjekt i qart\u00eb p\u00ebr t&#8217;u eksploruar, por n\u00eb t\u00eb v\u00ebrtet\u00eb misteri i origjin\u00ebs s\u00eb jet\u00ebs \u00ebsht\u00eb injoruar p\u00ebr dekada t\u00eb t\u00ebra. Ndoshta t\u00eb gjith\u00eb ishin ende tep\u00ebr t\u00eb lidhur emocionalisht me vitalizmin p\u00ebr t\u00eb nd\u00ebrmarr\u00eb hapin tjet\u00ebr.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Charles Darwin\" src=\"http:\/\/fjala.info\/2018\/p04d7hrq.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Charles Darwin tregoi se e gjith\u00eb jeta ka evoluar nga nj\u00eb paraardh\u00ebs i thjesht\u00eb, i p\u00ebrbashk\u00ebt<\/em><\/p>\n<\/blockquote>\n<p>N\u00eb vend t\u00eb k\u00ebsaj, zbulimi i madh biologjik i shekullit t\u00eb 19-t\u00eb ishte <a href=\"http:\/\/www.bbc.com\/earth\/story\/20150803-how-do-we-know-evolution-is-real\" target=\"_blank\" rel=\"noopener noreferrer\">teoria e evolucionit<\/a>, si\u00e7 u zhvillua nga Charles Darwin dhe t\u00eb tjer\u00ebt.<\/p>\n<blockquote><p><em>Darvini e dinte se ishte nj\u00eb \u00e7\u00ebshtje e thell\u00eb<\/em><\/p><\/blockquote>\n<p>Teoria e Darvinit, e paraqitur n\u00eb &#8220;<em>Nga origjina e specieve<\/em>&#8221; n\u00eb vitin 1859, shpjegoi se si shum\u00ebllojshm\u00ebria e madhe e jet\u00ebs mund t\u00eb dilte nga nj\u00eb paraardh\u00ebs i vet\u00ebm, i p\u00ebrbashk\u00ebt. N\u00eb vend t\u00eb secil\u00ebs prej llojeve t\u00eb ndryshme q\u00eb u krijuan individualisht nga Per\u00ebndia, t\u00eb gjith\u00eb ishin prej nj\u00eb organizmi fillestar, q\u00eb jetonin miliona vjet m\u00eb par\u00eb: paraardh\u00ebsi i fundit universal i p\u00ebrbashk\u00ebt.<\/p>\n<p>Kjo ide provoi jasht\u00ebzakonisht t\u00eb diskutueshme, p\u00ebrs\u00ebri p\u00ebr shkak se ajo ishte n\u00eb kund\u00ebrshtim edhe me Bibl\u00ebn. Darvini dhe idet\u00eb e tij u vun\u00eb n\u00ebn nj\u00eb sulm t\u00eb eg\u00ebr, ve\u00e7an\u00ebrisht nga t\u00eb krishter\u00ebt e zem\u00ebruar.<\/p>\n<p>Teoria e evolucionit nuk tha asgj\u00eb rreth asaj se si u krijua ai organiz\u00ebm i par\u00eb.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Pellg i vog\u00ebl uji t\u00eb ngroht\u00eb\" src=\"http:\/\/fjala.info\/2018\/p04cl2qn.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Darwin habitej, n\u00ebse jeta ka filluar n\u00eb nj\u00eb &#8220;pellg t\u00eb vog\u00ebl uji t\u00eb ngroht\u00eb&#8221;<\/em><br \/>\n(Credit: Linda Reinink-Smith\/Alamy)<\/p>\n<\/blockquote>\n<p>Darvini e dinte se ishte nj\u00eb \u00e7\u00ebshtje e thell\u00eb, por &#8211; ndoshta i kujdessh\u00ebm p\u00ebr fillimin e nj\u00eb lufte tjet\u00ebr me Kish\u00ebn &#8211; ai duket se e ka diskutuar \u00e7\u00ebshtjen n\u00eb nj\u00eb <a href=\"http:\/\/www.darwinproject.ac.uk\/editors-blog\/2012\/02\/15\/darwins-warm-little-pond\/\" target=\"_blank\" rel=\"noopener noreferrer\">let\u00ebr t\u00eb shkruar n\u00eb 1871<\/a>. Gjuha e tij e ngaz\u00ebllyer zbulon se e dinte r\u00ebnd\u00ebsin\u00eb e thell\u00eb t\u00eb pyetjes :<\/p>\n<blockquote><p><em>Hipoteza e par\u00eb p\u00ebr origjin\u00ebn e jet\u00ebs u shpik n\u00eb nj\u00eb vend t\u00eb eg\u00ebr totalitar<\/em><\/p><\/blockquote>\n<p>&#8220;Por <em>n\u00ebse <\/em>(dhe sa gj\u00eb e madhe kjo <em>n\u00ebse<\/em>) ne mund t\u00eb krijojm\u00eb n\u00eb nj\u00eb pellg t\u00eb ngroht\u00eb t\u00eb vog\u00ebl me t\u00eb gjitha llojet e amoniakut dhe krip\u00ebrave fosforike, drit\u00eb, nxeht\u00ebsi, energji elektrike &amp;c prezente, ajo p\u00ebrb\u00ebrje proteinash u formua kimikisht, e gatshme t\u00eb nd\u00ebrmarr\u00eb ndryshime t\u00eb m\u00ebtejshme komplekse&#8230;&#8221;<\/p>\n<p>Me fjal\u00eb t\u00eb tjera, \u00e7ka <em>n\u00ebse<\/em> ka qen\u00eb dikur nj\u00eb trup i vog\u00ebl uji, i mbushur me komponime t\u00eb thjeshta organike dhe t\u00eb lar\u00eb n\u00eb rrezet e diellit. Disa nga k\u00ebto komponime mund t\u00eb kombinohen p\u00ebr t\u00eb formuar nj\u00eb substanc\u00eb t\u00eb ngjashme me jet\u00ebn si nj\u00eb protein\u00eb, e cila pastaj mund t\u00eb filloj\u00eb t\u00eb evoluoj\u00eb dhe t\u00eb b\u00ebhet m\u00eb komplekse.<\/p>\n<p>Ishte nj\u00eb ide e \u00e7uditshme. Por do t\u00eb b\u00ebhej baza e hipotez\u00ebs s\u00eb par\u00eb p\u00ebr m\u00ebnyr\u00ebn se si filloi jeta.<\/p>\n<p>Kjo ide doli nga nj\u00eb vend i papritur. Ju mund t\u00eb mendoni se kjo pjes\u00eb e guximshme e t\u00eb menduarit t\u00eb lir\u00eb do t\u00eb ishte zhvilluar n\u00eb nj\u00eb vend demokratik, me nj\u00eb tradit\u00eb t\u00eb fjal\u00ebs s\u00eb lir\u00eb: ndoshta n\u00eb Shtetet e Bashkuara. Por n\u00eb fakt hipoteza e par\u00eb p\u00ebr origjin\u00ebn e jet\u00ebs u shpik n\u00eb nj\u00eb vend t\u00eb eg\u00ebr totalitar, ku u m\u00ebnjanua mendimi i lir\u00eb: BRSS.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Alexander Oparin\" src=\"http:\/\/fjala.info\/2018\/p04cl29f.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Alexander Oparin jetoi dhe punoi n\u00eb USSR<\/em> (Credit: Sputnik\/Science Photo Library)<\/p>\n<\/blockquote>\n<p>N\u00eb Rusin\u00eb e Stalinit, gjith\u00e7ka ishte n\u00ebn kontrollin e shtetit. Kjo p\u00ebrfshinte idet\u00eb e njer\u00ebzve, madje edhe n\u00eb tema &#8211; si biologjia &#8211; q\u00eb duken t\u00eb palidhura me politik\u00ebn komuniste.<\/p>\n<blockquote><p><em>Oparin imagjinonte se \u00e7far\u00eb ishte Toka kur sapo u formua<\/em><\/p><\/blockquote>\n<p>M\u00eb t\u00eb famshmja, Stalini n\u00eb m\u00ebnyr\u00eb efektive i ndaloi shkenc\u00ebtar\u00ebt t\u00eb studiojn\u00eb gjenetik\u00eb konvencionale. N\u00eb vend t\u00eb k\u00ebsaj ai vuri n\u00eb dukje <a href=\"https:\/\/link.springer.com\/article\/10.1007%2Fs10739-011-9287-3\" target=\"_blank\" rel=\"noopener noreferrer\">idet\u00eb<\/a> e nj\u00eb pun\u00ebtori t\u00eb ferm\u00ebs me emrin <a href=\"http:\/\/www.bbc.co.uk\/programmes\/b00bw51j\" target=\"_blank\" rel=\"noopener noreferrer\">Trofim Lysenko<\/a>, t\u00eb cilat ai mendonte se ishin m\u00eb n\u00eb p\u00ebrputhje me ideologjin\u00eb komuniste. Shkenc\u00ebtar\u00ebt q\u00eb punojn\u00eb n\u00eb gjenetik\u00eb jan\u00eb t\u00eb detyruar t\u00eb mb\u00ebshtesin publikisht idet\u00eb e Lysenkos, ose rrezikojn\u00eb t\u00eb p\u00ebrfundojn\u00eb n\u00eb nj\u00eb kamp pune.<\/p>\n<p>Ishte n\u00eb k\u00ebt\u00eb mjedis shtyp\u00ebs ku <strong>Aleksand\u00ebr Oparin<\/strong> kreu hulumtimet e tij n\u00eb biokim. Ai ishte n\u00eb gjendje t\u00eb vazhdonte t\u00eb punonte sepse ishte nj\u00eb komunist besnik: ai p\u00ebrkrahu idet\u00eb e Lysenkos dhe madje mori Urdhrin e Leninit, dekorimin m\u00eb t\u00eb lart\u00eb q\u00eb mund t&#8217;i jepej dikujt q\u00eb jetonte n\u00eb BRSS.<\/p>\n<p>N\u00eb vitin 1924, Oparin botoi librin e tij <a href=\"https:\/\/www.valencia.edu\/~orilife\/textos\/The%20Origin%20of%20Life.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Origjina e Jet\u00ebs<\/a>. N\u00eb t\u00eb ai krijoi nj\u00eb vizion p\u00ebr lindjen e jet\u00ebs q\u00eb ishte shum\u00eb e ngjashme me pellgun e ngroht\u00eb t\u00eb Darvinit.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Oqean\u00ebt\" src=\"http:\/\/fjala.info\/2018\/p04cl221.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Oqean\u00ebt u krijuan pasi Toka u ftohur<\/em> (Credit: Richard Bizley\/Science Photo Library)<\/p>\n<\/blockquote>\n<p>Oparin imagjinonte se \u00e7far\u00eb ishte Toka kur sapo u formua. Sip\u00ebrfaqja ishte tep\u00ebr e nxeht\u00eb, nd\u00ebrsa gur\u00ebt nga hap\u00ebsira binin mbi t\u00eb dhe zhyteshin posht\u00eb dhe shkriheshin. Ishte nj\u00eb rr\u00ebmuj\u00eb me shk\u00ebmbinj gjysm\u00eb t\u00eb shkrir\u00eb, q\u00eb p\u00ebrmbante nj\u00eb gam\u00eb t\u00eb madhe t\u00eb kimikateve &#8211; duke p\u00ebrfshir\u00eb shum\u00eb elemente me baz\u00eb karboni.<\/p>\n<p><strong><em>N\u00ebse ju shikoni <em>coacervates<\/em><sup>1<\/sup>) n\u00ebn nj\u00eb mikroskop, ata sillen si qelizat e gjalla t\u00eb shtangura<\/em><\/strong><\/p>\n<p>P\u00ebrfundimisht, Toka u ftoh dhe avujt e ujit u ngjesh\u00eb n\u00eb uj\u00eb t\u00eb l\u00ebngsh\u00ebm dhe ra edhe shiu i par\u00eb. Shum\u00eb koh\u00eb para se Toka t\u00eb kishte oqeane, t\u00eb cilat ishin t\u00eb nxehta dhe t\u00eb pasura me kimikate me baz\u00eb karboni. Tani dy gj\u00ebra mund t\u00eb ndodhin.<\/p>\n<p><em>S\u00eb pari<\/em>, kimikatet e ndryshme mund t\u00eb reagojn\u00eb me nj\u00ebri-tjetrin p\u00ebr t\u00eb formuar shum\u00eb komponime t\u00eb reja, disa prej t\u00eb cilave do t\u00eb ishin m\u00eb komplekse. Oparin mendonte se molekulat n\u00eb qend\u00ebr t\u00eb jet\u00ebs, si sheqernat dhe aminoacidet, t\u00eb gjitha mund t\u00eb formoheshin n\u00eb uj\u00ebrat e Tok\u00ebs.<\/p>\n<p><em>S\u00eb dyti<\/em>, disa nga kimikatet filluan t\u00eb formojn\u00eb struktura mikroskopike. Shum\u00eb kimikate organike nuk treten n\u00eb uj\u00eb: p\u00ebr shembull, vaji formon nj\u00eb shtres\u00eb n\u00eb maj\u00eb t\u00eb ujit. Por, kur disa nga kimikatet kontaktojn\u00eb me uj\u00eb, ato formojn\u00eb globula sferike t\u00eb quajtura &#8220;coacervates&#8221;, t\u00eb cilat mund t\u00eb jen\u00eb deri n\u00eb 0.01 cm (0.004 in\u00e7).<\/p>\n<p>N\u00ebse ju shikoni coacervates n\u00ebn nj\u00eb mikroskop, ata sillen si qelizat e gjalla t\u00eb shtangura. Ata rriten dhe ndryshojn\u00eb form\u00ebn, dhe nganj\u00ebher\u00eb ndahen n\u00eb dy. Ata gjithashtu mund t\u00eb marrin kimikate nga uji p\u00ebrreth, k\u00ebshtu q\u00eb kimikatet e ngjashme me jet\u00ebn mund t\u00eb p\u00ebrqendrohen brenda tyre. Oparin propozoi q\u00eb coacervates ishin paraardh\u00ebsit e qelizave moderne.<\/p>\n<blockquote><p><em>Ideja q\u00eb organizmat e gjall\u00eb mund t\u00eb formohen nga mjete t\u00eb thjeshta kimike, pa nj\u00eb zot apo edhe nj\u00eb &#8220;forc\u00eb t\u00eb jet\u00eb&#8221;, ishin radikale<\/em><\/p><\/blockquote>\n<p>Pes\u00eb vjet m\u00eb von\u00eb n\u00eb vitin 1929, biologu anglez <strong>J. B. S. Haldane<\/strong> propozoi n\u00eb m\u00ebnyr\u00eb t\u00eb pavarur disa ide shum\u00eb t\u00eb ngjashme n\u00eb nj\u00eb <a href=\"https:\/\/www.uv.es\/~orilife\/textos\/Haldane.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">artikull t\u00eb shkurt\u00ebr<\/a> t\u00eb botuar n\u00eb <a href=\"https:\/\/newhumanist.org.uk\/history\" target=\"_blank\" rel=\"noopener noreferrer\">Vjetor\u00ebn Racionaliste<\/a>.<\/p>\n<p>Haldani kishte b\u00ebr\u00eb tashm\u00eb nj\u00eb kontribut t\u00eb jasht\u00ebzakonsh\u00ebm n\u00eb teorin\u00eb e evolucionit, duke ndihmuar n\u00eb integrimin e ideve t\u00eb Darvinit me shkenc\u00ebn n\u00eb zhvillim t\u00eb gjenetik\u00ebs.<\/p>\n<p>Ai ishte gjithashtu nj\u00eb karakter m\u00eb i madh se vet\u00eb jeta. N\u00eb nj\u00eb rast, ai p\u00ebsoi nj\u00eb shpim t\u00eb daulles s\u00eb veshit, p\u00ebr shkak t\u00eb disa eksperimenteve me dhomat e dekompresionit, por m\u00eb von\u00eb ai shkruante se: &#8220;<em>daullet n\u00eb p\u00ebrgjith\u00ebsi sh\u00ebrohen, dhe n\u00ebse ka nj\u00eb vrim\u00eb n\u00eb t\u00eb, ndon\u00ebse \u00ebsht\u00eb disi i shurdh\u00ebr, dikush mund t\u00eb nxjerr\u00eb tym duhani nga veshi n\u00eb fjal\u00eb, gj\u00eb q\u00eb \u00ebsht\u00eb nj\u00eb arritje sociale<\/em>&#8220;.<\/p>\n<p>Ashtu si Oparin, Haldane p\u00ebrshkroi se si kimikatet organike mund t\u00eb nd\u00ebrtohen n\u00eb uj\u00eb, &#8220;[<em>deri sa] oqeanet primitive arrit\u00ebn konsistenc\u00ebn e sup\u00ebs s\u00eb nxeht\u00eb t\u00eb holluar<\/em>&#8220;. Kjo krijoi sken\u00ebn p\u00ebr &#8220;<em>formimin e gj\u00ebrave t\u00eb para t\u00eb gjalla ose gjysm\u00eb t\u00eb gjalla<\/em>&#8221; dhe p\u00ebr secil\u00ebn prej tyre t\u00eb mbyllet n\u00eb &#8220;<em>nj\u00eb film me vaj<\/em>&#8220;.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Haldane\" src=\"http:\/\/fjala.info\/2018\/p04clbq0.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Gjenetisti anglez J. B. S. Haldane<\/em> (Credit: Science Photo Library)<\/p>\n<\/blockquote>\n<p>Thuhet se nga t\u00eb gjith\u00eb biolog\u00ebt n\u00eb bot\u00eb, <strong>Oparin<\/strong> dhe <strong>Haldane<\/strong> e propozuan k\u00ebt\u00eb hipotez\u00eb. Ideja q\u00eb organizmat e gjall\u00eb t\u00eb formuara nga mjete thjesht kimike, pa nj\u00eb zot apo edhe nj\u00eb &#8220;forc\u00eb jete&#8221;, ishin radikale. Ashtu si teoria e evolucionit t\u00eb Darvinit p\u00ebrpara k\u00ebsaj, kjo e goditi n\u00eb fytyr\u00eb krishterimin.<\/p>\n<blockquote><p><em>Kishte nj\u00eb problem. Nuk kishte ende d\u00ebshmi eksperimentale p\u00ebr ta mb\u00ebshtetur at\u00eb<\/em><\/p><\/blockquote>\n<p>Kjo i p\u00ebrshtatej BRSS-s\u00eb mjaft mir\u00eb. Regjimi sovjetik ishte zyrtarisht ateist dhe lider\u00ebt e saj ishin t\u00eb etur p\u00ebr t\u00eb mb\u00ebshtetur shpjegime materialiste p\u00ebr fenomenet e thella si jeta. Haldani ishte gjithashtu nj\u00eb ateist dhe nj\u00eb komunist i p\u00ebrkushtuar si fillim.<\/p>\n<p>&#8220;<em>N\u00eb at\u00eb koh\u00eb, p\u00ebr t\u00eb pranuar ose jo k\u00ebt\u00eb ide, varej kryesisht nga personalitetet: qofshin ato fetare ose qofshin ata q\u00eb mb\u00ebshtesnin idet\u00eb e majt\u00eb apo komuniste<\/em>&#8220;, thot\u00eb eksperti i origjin\u00ebs <a href=\"https:\/\/scholar.google.com\/citations?user=Q7YTFCQAAAAJ&amp;hl=en\" target=\"_blank\" rel=\"noopener noreferrer\">Armen Mulkidjanian<\/a> i Universitetit t\u00eb Osnabr\u00fcck n\u00eb Gjermani. &#8220;<em>N\u00eb Bashkimin Sovjetik, ata u prit\u00ebn me k\u00ebnaq\u00ebsi, sepse nuk kishin nevoj\u00eb p\u00ebr Per\u00ebndin\u00eb. N\u00eb bot\u00ebn per\u00ebndimore, n\u00ebse do t\u00eb shikoni p\u00ebr njer\u00ebzit q\u00eb mendonin n\u00eb k\u00ebt\u00eb drejtim, t\u00eb gjith\u00eb ishin t\u00eb majt\u00eb, komunist\u00eb e k\u00ebshtu me radh\u00eb<\/em>&#8220;.<\/p>\n<p>Ideja q\u00eb jeta \u00ebsht\u00eb formuar n\u00eb nj\u00eb sup\u00eb primordiale t\u00eb kimikateve organike u b\u00eb e njohur si <strong>hipoteza Oparin-Haldane<\/strong>. Ishte e past\u00ebr dhe bind\u00ebse, por kishte nj\u00eb problem. <strong>Nuk kishte d\u00ebshmi eksperimentale p\u00ebr ta mb\u00ebshtetur at\u00eb<\/strong>. Kjo nuk do t\u00eb arrij\u00eb pothuajse nj\u00eb \u00e7erek shekulli.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Harold Urey\" src=\"http:\/\/fjala.info\/2018\/p04cl39t.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Harold Urey<\/em><br \/>\n(Credit: Emilio Segre Visual Archives\/American Institute of Physics\/Science Photo Library)<\/p>\n<\/blockquote>\n<p>N\u00eb koh\u00ebn kur <a href=\"http:\/\/rsbm.royalsocietypublishing.org\/content\/roybiogmem\/29\/622\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Harold Urey<\/strong><\/a> u interesua p\u00ebr origjin\u00ebn e jet\u00ebs, ai tashm\u00eb <a href=\"https:\/\/www.nobelprize.org\/nobel_prizes\/chemistry\/laureates\/1934\/\" target=\"_blank\" rel=\"noopener noreferrer\">kishte fituar \u00e7mimin Nobel t\u00eb Kimis\u00eb<\/a> n\u00eb vitin 1934 dhe ndihmoi n\u00eb nd\u00ebrtimin e bomb\u00ebs atomike. Gjat\u00eb Luft\u00ebs s\u00eb Dyt\u00eb Bot\u00ebrore, Urey punoi n\u00eb Projektin Manhattan, duke mbledhur uraniumin e paq\u00ebndruesh\u00ebm 235 t\u00eb nevojsh\u00ebm p\u00ebr thelbin e bomb\u00ebs. Pas luft\u00ebs ai luftoi p\u00ebr t\u00eb mbajtur teknologjin\u00eb b\u00ebrthamore n\u00ebn kontroll civil.<\/p>\n<blockquote><p><em>N\u00eb vitin 1952, Milleri filloi eksperimentin m\u00eb t\u00eb famsh\u00ebm mbi origjin\u00ebn e jet\u00ebs, q\u00eb u p\u00ebrpoq ndonj\u00ebher\u00eb<\/em><\/p><\/blockquote>\n<p>Ai gjithashtu u interesua p\u00ebr kimin\u00eb e hap\u00ebsir\u00ebs s\u00eb jashtme, ve\u00e7an\u00ebrisht at\u00eb q\u00eb vazhdoi kur sistemi diellor po formohej. Nj\u00eb dit\u00eb ai dha nj\u00eb leksion dhe vuri n\u00eb dukje se ndoshta nuk kishte oksigjen n\u00eb atmosfer\u00ebn e Tok\u00ebs kur u formua s\u00eb pari. Kjo do t\u00eb kishte ofruar kushte ideale p\u00ebr t\u00eb formuar sup\u00eb primare t\u00eb Oparin dhe Haldane: kimikatet e brishta do t\u00eb ishin shkat\u00ebrruar nga kontakti me oksigjenin.<\/p>\n<p>Nj\u00eb student i doktoratur\u00ebs me emrin <strong>Stanley Miller<\/strong> ishte n\u00eb audienc\u00eb dhe m\u00eb von\u00eb iu afrua Urey me nj\u00eb propozim: a mund ta provonin ata k\u00ebt\u00eb ide? Urey ishte skeptik, por Milleri e bindi at\u00eb t\u00eb merrej me k\u00ebt\u00eb.<\/p>\n<p>Pra, n\u00eb vitin 1952, Milleri filloi eksperimentin m\u00eb t\u00eb famsh\u00ebm mbi origjin\u00ebn e jet\u00ebs q\u00eb u p\u00ebrpoq ndonj\u00ebher\u00eb.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Eksperimenti Miller-Urey\" src=\"http:\/\/fjala.info\/2018\/p04clc2m.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Eksperimenti Miller-Urey<\/em> (Credit: Francis Leroy, Biocosmos\/Science Photo Library)<\/p>\n<\/blockquote>\n<p>Vendosja ishte e thjesht\u00eb. Milleri lidhi nj\u00eb seri flakash qelqi dhe qarkullonte kat\u00ebr kimikate, q\u00eb ai dyshonte se ishin t\u00eb pranish\u00ebm n\u00eb Tok\u00ebn e hershme: uj\u00eb t\u00eb val\u00eb, gaz hidrogjeni, amoniak dhe metan. Ai i n\u00ebnshtroi gazrat ndaj goditjeve t\u00eb p\u00ebrs\u00ebritura elektrike, p\u00ebr t\u00eb simuluar sulmet e rrufes\u00eb, q\u00eb do t\u00eb kishin qen\u00eb nj\u00eb dukuri e zakonshme n\u00eb Tok\u00eb shum\u00eb koh\u00eb m\u00eb par\u00eb.<\/p>\n<blockquote><p><em>Ju mund t\u00eb shkoni n\u00eb nj\u00eb atmosfer\u00eb t\u00eb thjesht\u00eb dhe t\u00eb prodhoni shum\u00eb molekula biologjike<\/em><\/p><\/blockquote>\n<p>Miller gjeti se &#8220;<em>uji n\u00eb balon\u00eb u b\u00eb duksh\u00ebm tr\u00ebndafili pas dit\u00ebs s\u00eb par\u00eb dhe deri n\u00eb fund t\u00eb jav\u00ebs zgjidhja ishte e kuqe e thell\u00eb dhe e turbullt<\/em>&#8220;. \u00cbsht\u00eb e qart\u00eb q\u00eb \u00ebsht\u00eb formuar nj\u00eb p\u00ebrzierje e kimikateve.<\/p>\n<p>Kur Miller analizoi p\u00ebrzierjen ai gjeti se p\u00ebrmbante dy aminoacide: <strong>glycine<\/strong> dhe <strong>alanine<\/strong>. Aminoacidet shpesh p\u00ebrshkruhen si blloqet e nd\u00ebrtimit t\u00eb jet\u00ebs. Ato p\u00ebrdoren p\u00ebr t\u00eb formuar proteinat, q\u00eb kontrollojn\u00eb shumic\u00ebn e proceseve biokimike n\u00eb trupin ton\u00eb. Milleri kishte b\u00ebr\u00eb dy nga komponent\u00ebt m\u00eb t\u00eb r\u00ebnd\u00ebsish\u00ebm t\u00eb jet\u00ebs, nga e para.<\/p>\n<p>Rezultatet u publikuan n\u00eb <a href=\"http:\/\/science.sciencemag.org\/content\/117\/3046\/528\" target=\"_blank\" rel=\"noopener noreferrer\">revist\u00ebn prestigjioze Science n\u00eb vitin 1953<\/a>. Urey, n\u00eb nj\u00eb veprim vet\u00ebmohues t\u00eb pazakont\u00eb midis shkenc\u00ebtar\u00ebve t\u00eb vjet\u00ebr, e mori emrin e tij nga letra, duke i dh\u00ebn\u00eb kredi vet\u00ebm Miller p\u00ebr eksperimentin e arritjet. P\u00ebrkund\u00ebr k\u00ebsaj, studimi njihet shpesh si &#8220;<a href=\"http:\/\/science.sciencemag.org\/content\/322\/5900\/404\" target=\"_blank\" rel=\"noopener noreferrer\">Eksperimenti Miller-Urey<\/a>&#8220;.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Stanley Miller n\u00eb laboratorin e tij\" src=\"http:\/\/fjala.info\/2018\/p04cl1r3.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Stanley Miller n\u00eb laboratorin e tij<\/em> (Credit: Science Photo Library)<\/p>\n<\/blockquote>\n<p>&#8220;<em>Forca e Miller-Urey \u00ebsht\u00eb t\u00eb tregoj\u00eb se mund t\u00eb shkosh nga nj\u00eb atmosfer\u00eb e thjesht\u00eb dhe t\u00eb prodhosh shum\u00eb molekula biologjike<\/em>&#8220;, thot\u00eb <a href=\"http:\/\/www2.mrc-lmb.cam.ac.uk\/group-leaders\/n-to-s\/john-sutherland\/\" target=\"_blank\" rel=\"noopener noreferrer\">John Sutherland<\/a> i Laboratorit t\u00eb Biologjis\u00eb Molekulare n\u00eb Kembrixh t\u00eb Britanis\u00eb s\u00eb Madhe.<\/p>\n<p><strong><em>Jeta qenka m\u00eb e nd\u00ebrlikuar, se \u00e7&#8217;ishte menduar<\/em><\/strong><\/p>\n<p>Detajet treguan se ishin t\u00eb gabuara, pasi studimet e m\u00ebvonshme treguan se atmosfera e hershme e Tok\u00ebs kishte nj\u00eb p\u00ebrzierje t\u00eb ndryshme t\u00eb gazrave. Por kjo \u00ebsht\u00eb pothuajse pran\u00eb pik\u00ebs n\u00eb fjal\u00eb.<\/p>\n<p>&#8220;<em>Ishte nj\u00eb masivizim ikonik, stimuloi imagjinat\u00ebn e publikut dhe vazhdon t\u00eb p\u00ebrmendet gjer\u00ebsisht<\/em>&#8220;, thot\u00eb Sutherland.<\/p>\n<p>Pas eksperimentit t\u00eb Millerit, shkenc\u00ebtar\u00eb t\u00eb tjer\u00eb filluan t\u00eb gjejn\u00eb m\u00ebnyra p\u00ebr t\u00eb b\u00ebr\u00eb molekula t\u00eb thjeshta biologjike nga e para. Nj\u00eb zgjidhje p\u00ebr misterin e origjin\u00ebs s\u00eb jet\u00ebs dukej e af\u00ebrt.<\/p>\n<p>Por m\u00eb pas u b\u00eb e qart\u00eb se jeta ishte m\u00eb e komplikuar sesa mendonte dikush. Qelizat e gjalla, doli, nuk ishin vet\u00ebm \u00e7anta me kimikate: ata ishin makina t\u00eb nd\u00ebrlikuara. Papritmas, duke e b\u00ebr\u00eb nj\u00eb nga e para, filluan t\u00eb duken si nj\u00eb sfid\u00eb shum\u00eb m\u00eb e madhe, sesa shkenc\u00ebtar\u00ebt e kishin parashikuar.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Makineria brenda qelizave\" src=\"http:\/\/fjala.info\/2018\/p04clbxg.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Makineria brenda qelizave \u00ebsht\u00eb e pabesueshme dhe intriguese<\/em><br \/>\n(Credit: Equinox Graphics Ltd)<\/p>\n<\/blockquote>\n<p><strong>Kapitulli 2. Polarizimi i madh<\/strong><\/p>\n<p>Nga fillim t\u00eb viteve 1950, shkenc\u00ebtar\u00ebt ishin larguar nga supozimi i gjat\u00eb, q\u00eb jeta ishte nj\u00eb dhurat\u00eb nga per\u00ebndit\u00eb. Ata kishin filluar t\u00eb shqyrtonin mund\u00ebsin\u00eb q\u00eb jeta t\u00eb formohej spontanisht dhe natyrsh\u00ebm n\u00eb Tok\u00ebn e hershme &#8211; dhe fal\u00eb eksperimentit ikonik t\u00eb Stanley Miller, ata madje kishin nj\u00eb mb\u00ebshtetje praktike p\u00ebr k\u00ebt\u00eb ide.<\/p>\n<p>Nd\u00ebrsa Miller po p\u00ebrpiqej t\u00eb b\u00ebnte gj\u00ebrat e jet\u00ebs nga e para, shkenc\u00ebtar\u00eb t\u00eb tjer\u00eb po kuptonin se nga cilat gjene ishim b\u00ebr\u00eb.<\/p>\n<p>Deri n\u00eb k\u00ebt\u00eb koh\u00eb, shum\u00eb molekula biologjike ishin t\u00eb njohura. K\u00ebto p\u00ebrfshinin sheqer, yndyrna, proteina &#8211; dhe acide nukleike t\u00eb tilla si &#8220;<em>acid deoxyribonucleic<\/em>&#8220;, ose <strong>ADN<\/strong> p\u00ebr ta shkurt\u00ebr.<\/p>\n<blockquote><p><em>Ata b\u00ebn\u00eb nj\u00eb nga zbulimet m\u00eb t\u00eb m\u00ebdha shkencore t\u00eb shekullit t\u00eb 20-t\u00eb<\/em><\/p><\/blockquote>\n<p>Sot ne e marrim si t\u00eb mir\u00ebqen\u00eb se ADN-ja mbart gjenet tona, por kjo n\u00eb fakt erdhi si nj\u00eb tronditje p\u00ebr biolog\u00ebt e viteve 1950. Proteinat jan\u00eb m\u00eb komplekse, k\u00ebshtu q\u00eb shkenc\u00ebtar\u00ebt mendonin se ishin gjenet.<\/p>\n<p>Kjo ide u hodh posht\u00eb n\u00eb vitin 1952 nga <strong>Alfred Hershey<\/strong> dhe <strong>Martha Chase<\/strong> nga Institucioni Carnegie i Uashingtonit. Ata studiuan viruse t\u00eb thjeshta q\u00eb p\u00ebrmbajn\u00eb vet\u00ebm ADN dhe proteina dhe t\u00eb cilat duhet t\u00eb infektojn\u00eb bakteret n\u00eb m\u00ebnyr\u00eb q\u00eb t\u00eb riprodhohen. Ata gjet\u00ebn se ishte ADN virale, q\u00eb hyri n\u00eb baktere: <a href=\"http:\/\/jgp.rupress.org\/content\/36\/1\/39\" target=\"_blank\" rel=\"noopener noreferrer\">proteinat q\u00ebndruan jasht\u00eb<\/a>. <strong>\u00cbsht\u00eb e qart\u00eb se ADN-ja ishte materiali gjenetik<\/strong>.<\/p>\n<p>Rezultatet e Hershey dhe Chase shkaktuan nj\u00eb gar\u00eb t\u00eb furish\u00ebm p\u00ebr t\u00eb zbuluar struktur\u00ebn e ADN-s\u00eb, dhe k\u00ebshtu shkoi kjo pun\u00eb. Nj\u00eb vit m\u00eb pas, problemi u plasua nga <a href=\"https:\/\/profiles.nlm.nih.gov\/ps\/retrieve\/Narrative\/SC\/p-nid\/141\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Francis Crick<\/strong><\/a> dhe <a href=\"https:\/\/www.nobelprize.org\/nobel_prizes\/medicine\/laureates\/1962\/watson-bio.html\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>James Watson<\/strong><\/a> nga Universiteti i Kembrixhit, n\u00eb Mbret\u00ebrin\u00eb e Bashkuar &#8211; me shum\u00eb ndihm\u00eb t\u00eb n\u00ebnvler\u00ebsuar nga kolegu i tyre <a href=\"https:\/\/profiles.nlm.nih.gov\/ps\/retrieve\/Narrative\/KR\/p-nid\/183\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Rosalind Franklin<\/strong><\/a>.<\/p>\n<p>Kjo ishte nj\u00eb nga zbulimet m\u00eb t\u00eb m\u00ebdha shkencore t\u00eb shekullit t\u00eb 20-t\u00eb. Ai gjithashtu e ridrejtoi k\u00ebrkimin p\u00ebr origjin\u00ebn e jet\u00ebs, duke zbuluar ngat\u00ebrres\u00ebn e pabesueshme q\u00eb \u00ebsht\u00eb e fshehur brenda qelizave t\u00eb gjalla.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"James Watson dhe Francis Crick\" src=\"http:\/\/fjala.info\/2018\/p04cl2x3.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>James Watson dhe Francis Crick me modelin e tyre t\u00eb ADN-s\u00eb<\/em><br \/>\n(Credit: A. Barrington-Brown\/Gonville and Caius College\/Science Photo Library)<\/p>\n<\/blockquote>\n<p>Crick dhe Watson kuptuan se ADN \u00ebsht\u00eb nj\u00eb spirale e dyfisht\u00eb, si nj\u00eb shkall\u00eb q\u00eb \u00ebsht\u00eb shtremb\u00ebruar n\u00eb spirale. T\u00eb dy &#8220;shtyllat&#8221; e shkall\u00ebs jan\u00eb nd\u00ebrtuar secila prej molekulave t\u00eb quajtura nukleotide.<\/p>\n<blockquote><p><em>Gjenet tuaja vijn\u00eb n\u00eb fund t\u00eb fundit nga nj\u00eb bakter st\u00ebrgjyshor<\/em><\/p><\/blockquote>\n<p>Kjo struktur\u00eb shpjegoi se si qelizat kopjojn\u00eb ADN-n\u00eb e tyre. Me fjal\u00eb t\u00eb tjera, zbuloi se si prind\u00ebrit b\u00ebjn\u00eb kopje t\u00eb gjeneve t\u00eb tyre dhe i kalojn\u00eb ato tek f\u00ebmij\u00ebt e tyre.<\/p>\n<p>\u00c7\u00ebshtja ky\u00e7e \u00ebsht\u00eb se spiralja e dyfisht\u00eb mund t\u00eb &#8220;hiqet&#8221;. Kjo ekspozon kodin gjenetik &#8211; i p\u00ebrb\u00ebr\u00eb nga sekuenca t\u00eb bazave gjenetike A (adenin\u00eb), T (timin\u00eb), C (citozin\u00eb) dhe G (guanin\u00eb) &#8211; q\u00eb normalisht mbyllen brenda &#8220;rungs&#8221; (k\u00ebmb\u00eb shkalle) t\u00eb shkall\u00ebve t\u00eb ADN-s\u00eb. \u00c7do varg p\u00ebrdoret pastaj si nj\u00eb shabllon p\u00ebr t\u00eb rikrijuar nj\u00eb kopje t\u00eb tjetr\u00ebs.<\/p>\n<p>Duke p\u00ebrdorur k\u00ebt\u00eb mekaniz\u00ebm, gjenet jan\u00eb kaluar nga prind\u00ebrit te f\u00ebmij\u00ebt, q\u00eb nga fillimi i jet\u00ebs. Gjenet tuaja vijn\u00eb n\u00eb fund t\u00eb fundit nga nj\u00eb bakter st\u00ebrgjyshor &#8211; dhe n\u00eb \u00e7do hap ata u kopjuan duke p\u00ebrdorur mekanizmin, q\u00eb Crick dhe Watson zbuluan.<\/p>\n<hr \/>\n<p><!-- Composite Start --><\/p>\n<div id=\"M303968ScriptRootC194856\">\n<div id=\"M303968PreloadC194856\">Loading&#8230;<\/div>\n<p><script>\n                (function(){\n            var D=new Date(),d=document,b='body',ce='createElement',ac='appendChild',st='style',ds='display',n='none',gi='getElementById';\n            var i=d[ce]('iframe');i[st][ds]=n;d[gi](\"M303968ScriptRootC194856\")[ac](i);try{var iw=i.contentWindow.document;iw.open();iw.writeln(\"<ht\"+\"ml><bo\"+\"dy><\/bo\"+\"dy><\/ht\"+\"ml>\");iw.close();var c=iw[b];}\n            catch(e){var iw=d;var c=d[gi](\"M303968ScriptRootC194856\");}var dv=iw[ce]('div');dv.id=\"MG_ID\";dv[st][ds]=n;dv.innerHTML=194856;c[ac](dv);\n            var s=iw[ce]('script');s.async='async';s.defer='defer';s.charset='utf-8';s.src=\"\/\/jsc.mgid.com\/f\/j\/fjala.info.194856.js?t=\"+D.getYear()+D.getMonth()+D.getDate()+D.getHours();c[ac](s);})();\n    <\/script><\/p>\n<\/div>\n<p><!-- Composite End --><\/p>\n<hr \/>\n<p>Exploro struktur\u00ebn e ADN-s\u00eb n\u00eb k\u00ebt\u00eb video:<br \/>\n(<em>videon shikojeni n\u00eb <a href=\"http:\/\/www.bbc.com\/earth\/story\/20161026-the-secret-of-how-life-on-earth-began\" target=\"_blank\" rel=\"noopener noreferrer\">shkrimin origjinal<\/a>, pasi nuk mund\u00ebm ta fusnim k\u00ebtu<\/em>)<\/p>\n<p>Crick dhe Watson zbuluan gjetjet e tyre n\u00eb <a href=\"https:\/\/www.nature.com\/articles\/171737a0.epdf\" target=\"_blank\" rel=\"noopener noreferrer\">nj\u00eb let\u00ebr t\u00eb vitit 1953<\/a> n\u00eb Nature. Gjat\u00eb disa viteve t\u00eb ardhshme, biokimist\u00ebt nxit\u00ebn t\u00eb kuptonin sakt\u00ebsisht se \u00e7far\u00eb informacioni mbart ADN-ja dhe se si p\u00ebrdoret ky informacion n\u00eb qelizat e gjalla. Sekretet m\u00eb t\u00eb thella t\u00eb jet\u00ebs po ekspozoheshin p\u00ebr her\u00eb t\u00eb par\u00eb.<\/p>\n<blockquote><p><em>Papritmas, idet\u00eb e Oparin dhe Haldane dukeshin naivisht tep\u00ebr t\u00eb thjeshta<\/em><\/p><\/blockquote>\n<p>Doli se ADN ka vet\u00ebm nj\u00eb pun\u00eb. <a href=\"https:\/\/www.nature.com\/articles\/227561a0.epdf\" target=\"_blank\" rel=\"noopener noreferrer\">ADN-ja juaj i tregon qelizave tuaja se si t\u00eb b\u00ebjn\u00eb proteina<\/a>: molekulat q\u00eb kryejn\u00eb nj\u00eb s\u00ebr\u00eb detyrash thelb\u00ebsore. Pa proteina nuk mund ta tretni ushqimin tuaj, zemra juaj do t\u00eb ndalet dhe ju nuk mund t\u00eb merrni frym\u00eb.<\/p>\n<p>Por procesi i p\u00ebrdorimit t\u00eb ADN-s\u00eb p\u00ebr t\u00eb b\u00ebr\u00eb proteina u provua t\u00eb jet\u00eb shum\u00eb i nd\u00ebrlikuar. Ky ishte nj\u00eb problem i madh p\u00ebr k\u00ebdo, q\u00eb p\u00ebrpiqet t\u00eb shpjegoj\u00eb origjin\u00ebn e jet\u00ebs, sepse \u00ebsht\u00eb e v\u00ebshtir\u00eb t\u00eb imagjinohet se si di\u00e7ka kaq komplekse mund t\u00eb ket\u00eb filluar ndonj\u00ebher\u00eb.<\/p>\n<p>\u00c7do protein\u00eb \u00ebsht\u00eb n\u00eb thelb nj\u00eb zinxhir i gjat\u00eb i aminoacideve, i lidhur s\u00eb bashku n\u00eb nj\u00eb m\u00ebnyr\u00eb specifike. Sekuenca e aminoacideve p\u00ebrcakton form\u00ebn tridimensionale t\u00eb protein\u00ebs, dhe k\u00ebshtu se \u00e7far\u00eb b\u00ebn.<\/p>\n<p>Ky informacion \u00ebsht\u00eb koduar <a href=\"http:\/\/www.biology-pages.info\/C\/Codons.html\" target=\"_blank\" rel=\"noopener noreferrer\">n\u00eb sekuenc\u00ebn e bazave t\u00eb ADN-s\u00eb<\/a>. Pra, kur nj\u00eb qeliz\u00eb duhet t\u00eb b\u00ebj\u00eb nj\u00eb protein\u00eb t\u00eb ve\u00e7ant\u00eb, ai lexon gjenin p\u00ebrkat\u00ebs n\u00eb ADN p\u00ebr t\u00eb marr\u00eb sekuenc\u00ebn e aminoacideve.<\/p>\n<blockquote><p><em>Doli se ADN ka vet\u00ebm nj\u00eb pun\u00eb<\/em><\/p><\/blockquote>\n<p>Por ka nj\u00eb kthes\u00eb. ADN-ja \u00ebsht\u00eb e \u00e7muar, k\u00ebshtu q\u00eb qelizat preferojn\u00eb ta mbajn\u00eb at\u00eb n\u00eb m\u00ebnyr\u00eb t\u00eb sigurt\u00eb. P\u00ebr k\u00ebt\u00eb arsye, ata kopjojn\u00eb informacionin nga ADN-ja n\u00eb molekula t\u00eb shkurtra t\u00eb nj\u00eb substance tjet\u00ebr t\u00eb quajtur <strong>ARN<\/strong> (<em>acid ribonukleik<\/em>). N\u00ebse ADN-ja \u00ebsht\u00eb nj\u00eb lib\u00ebr biblioteke, ARN \u00ebsht\u00eb nj\u00eb cop\u00ebz letre me nj\u00eb pasazh ky\u00e7 t\u00eb shkruar mbi t\u00eb. ARN \u00ebsht\u00eb e ngjashme me ADN-n\u00eb, p\u00ebrve\u00e7 se ka vet\u00ebm nj\u00eb varg.<\/p>\n<p>S\u00eb fundi, procesi i konvertimit t\u00eb informacionit n\u00eb at\u00eb pjes\u00eb t\u00eb ARN, n\u00eb nj\u00eb protein\u00eb, zhvillohet n\u00eb nj\u00eb molekul\u00eb jasht\u00ebzakonisht t\u00eb p\u00ebrpunuar t\u00eb quajtur &#8220;<em>ribosome<\/em>&#8221; (ribozom).<\/p>\n<p>Ky proces ndodh n\u00eb \u00e7do qeliz\u00eb t\u00eb gjall\u00eb, madje edhe n\u00eb bakteret m\u00eb t\u00eb thjeshta. \u00cbsht\u00eb po aq e r\u00ebnd\u00ebsishme p\u00ebr jet\u00ebn, si ushqimi dhe fryma. \u00c7do shpjegim p\u00ebr origjin\u00ebn e jet\u00ebs, duhet t\u00eb tregoj\u00eb se si u krijua ky trinitet kompleks &#8211; <strong>ADN<\/strong>-ja, <strong>ARN<\/strong>-ja dhe <strong>proteina ribozom<\/strong> &#8211; dhe si filloi t\u00eb punoj\u00eb.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Qelizat - shum\u00eb intriguese\" src=\"http:\/\/fjala.info\/2018\/p04cl97n.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Qelizat mund t\u00eb b\u00ebhen shum\u00eb intriguese<\/em><br \/>\n(Credit: Russell Kightley\/Science Photo Library)<\/p>\n<\/blockquote>\n<p>Papritur, idet\u00eb e Oparin dhe Haldane dukeshin naivisht t\u00eb thjeshta, nd\u00ebrsa eksperimenti i Millerit, i cili prodhonte vet\u00ebm disa nga aminoacidet, q\u00eb p\u00ebrdoren p\u00ebr t\u00eb nd\u00ebrtuar proteina, dukeshin amatore. Shum\u00eb larg nga marrja e rrug\u00ebs p\u00ebr krijimin e jet\u00ebs, studimi i tij kryesor ishte thjesht hapi i par\u00eb n\u00eb nj\u00eb rrug\u00eb t\u00eb gjat\u00eb.<\/p>\n<blockquote><p><em>Ideja q\u00eb jeta filloi me ARN-n\u00eb, do t\u00eb rezultonte me nj\u00eb ndikim t\u00eb jasht\u00ebzakonsh\u00ebm<\/em><\/p><\/blockquote>\n<p>&#8220;<em>ADN-ja e b\u00ebn ARN-n\u00eb t\u00eb prodhoj\u00eb proteina, t\u00eb gjitha n\u00eb k\u00ebt\u00eb qese lipidi t\u00eb p\u00ebrfshira n\u00eb kimikate<\/em>&#8220;, thot\u00eb John Sutherland. &#8220;<em>Ju do e shikoni at\u00eb dhe kjo \u00ebsht\u00eb vet\u00ebm &#8216;wow, kjo \u00ebsht\u00eb shum\u00eb e komplikuar&#8217;. Si do t\u00eb gjejm\u00eb nj\u00eb kimi organike, q\u00eb do t\u00eb b\u00ebj\u00eb gjith\u00e7ka n\u00eb nj\u00eb t\u00eb till\u00eb?<\/em>&#8221;<\/p>\n<p>Personi i par\u00eb, q\u00eb me t\u00eb v\u00ebrtet\u00eb u mor me trajtimin e k\u00ebsaj kok\u00eb-m\u00eb-vete, ishte nj\u00eb kimist britanik me emrin <a href=\"http:\/\/rsbm.royalsocietypublishing.org\/content\/roybiogmem\/59\/277\" target=\"_blank\" rel=\"noopener noreferrer\">Leslie Orgel<\/a>. Ai ishte nj\u00eb nga t\u00eb par\u00ebt q\u00eb e shihte modelin e ADN-s\u00eb s\u00eb Crick dhe Watson dhe m\u00eb von\u00eb do ta <a href=\"https:\/\/www.the-scientist.com\/?articles.view\/articleNo\/25641\/title\/Leslie-Orgel-dies\/\" target=\"_blank\" rel=\"noopener noreferrer\">ndihmonte NASA<\/a>-n me programin e tyre Viking, i cili d\u00ebrgoi zbarkues robotik\u00eb n\u00eb Mars.<\/p>\n<p>Orgel u nis p\u00ebr ta thjeshtuar problemin. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/0022283668903938?via%3Dihub\" target=\"_blank\" rel=\"noopener noreferrer\">Duke shkruar n\u00eb vitin 1968<\/a>, dhe <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/0022283668903926?via%3Dihub\" target=\"_blank\" rel=\"noopener noreferrer\">mb\u00ebshtetur nga Crick<\/a>, ai sugjeroi se jeta e par\u00eb nuk kishte proteina apo ADN. N\u00eb vend t\u00eb k\u00ebsaj, ajo u b\u00eb pothuajse t\u00ebr\u00ebsisht nga ARN. Q\u00eb kjo t\u00eb funksionoj\u00eb, k\u00ebto molekula primare t\u00eb ARN duhet t\u00eb ken\u00eb qen\u00eb ve\u00e7an\u00ebrisht t\u00eb gjithanshme. P\u00ebr nj\u00eb gj\u00eb, ata duhet t\u00eb ken\u00eb qen\u00eb n\u00eb gjendje t\u00eb krijojn\u00eb kopje t\u00eb vetes, me sa duket duke p\u00ebrdorur t\u00eb nj\u00ebjtin mekaniz\u00ebm baz\u00eb si ADN-ja.<\/p>\n<p>Ideja q\u00eb jeta filloi me ARN do t\u00eb rezultonte me ndikim t\u00eb jasht\u00ebzakonsh\u00ebm. Por ajo gjithashtu shkaktoi nj\u00eb luft\u00eb shkencore, q\u00eb ka zgjatur deri n\u00eb dit\u00ebt e sotme.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"ADN \u00ebsht\u00eb n\u00eb zemr\u00ebn e \u00e7do krijese\" src=\"http:\/\/fjala.info\/2018\/p04cl2rf.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>ADN \u00ebsht\u00eb n\u00eb zemr\u00ebn e pothuajse \u00e7do krijese t\u00eb gjall\u00eb<\/em><br \/>\n(Credit: Equinox Graphics Ltd)<\/p>\n<\/blockquote>\n<p>Duke sugjeruar se jeta filloi me ARN dhe pak tjet\u00ebr, Orgel propozonte q\u00eb nj\u00eb aspekt i r\u00ebnd\u00ebsish\u00ebm i jet\u00ebs &#8211; aft\u00ebsia e tij p\u00ebr t\u00eb riprodhuar veten &#8211; u paraqit para t\u00eb gjith\u00eb t\u00eb tjer\u00ebve. N\u00eb nj\u00ebfar\u00eb kuptimi, ai nuk ishte vet\u00ebm duke sugjeruar se si u mblodh p\u00ebr her\u00eb t\u00eb par\u00eb jeta: ai po thoshte di\u00e7ka rreth asaj se \u00e7ka \u00ebsht\u00eb jeta.<\/p>\n<blockquote><p><em>Shkenc\u00ebtar\u00ebt q\u00eb studiojn\u00eb origjin\u00ebn e jet\u00ebs ndahen n\u00eb kampe<\/em><\/p><\/blockquote>\n<p>Shum\u00eb biolog\u00eb do t\u00eb pajtoheshin me iden\u00eb e &#8220;p\u00ebrs\u00ebritjes s\u00eb par\u00eb&#8221; t\u00eb Orgel-it. N\u00eb teorin\u00eb e evolucionit t\u00eb Darvinit, aft\u00ebsia p\u00ebr t\u00eb krijuar pasardh\u00ebs \u00ebsht\u00eb absolutisht qendrore: e vetmja m\u00ebnyr\u00eb q\u00eb nj\u00eb organiz\u00ebm mund t\u00eb &#8220;fitoj\u00eb&#8221; \u00ebsht\u00eb t\u00eb l\u00ebr\u00eb pas shum\u00eb f\u00ebmij\u00eb.<\/p>\n<p>Por ka edhe tipare t\u00eb tjera t\u00eb jet\u00ebs q\u00eb duken nj\u00ebsoj thelb\u00ebsore. M\u00eb e dukshmja \u00ebsht\u00eb metabolizmi: aft\u00ebsia p\u00ebr nxjerrjen e energjis\u00eb nga mjedisi juaj dhe p\u00ebrdorimi i saj p\u00ebr t\u00eb mbajtur veten t\u00eb gjall\u00eb. P\u00ebr shum\u00eb biolog\u00eb, metabolizmi duhet t\u00eb ket\u00eb qen\u00eb tipar origjinal i jet\u00ebs, me replikimin e shfaqur m\u00eb von\u00eb.<\/p>\n<p>Pra, q\u00eb nga vitet 1960 e k\u00ebtej, shkenc\u00ebtar\u00ebt q\u00eb studiojn\u00eb origjin\u00ebn e jet\u00ebs u ndan\u00eb n\u00eb kampe.<\/p>\n<p>&#8220;<em>Polarizimi baz\u00eb ishte metabolizmi &#8211; i pari, kundrejt gjenetik\u00ebs &#8211; i pari<\/em>&#8220;, thot\u00eb Sutherland.<\/p>\n<blockquote><p><em>Takimet shkencore mbi origjin\u00ebn e jet\u00ebs kan\u00eb qen\u00eb shpesh takime t\u00eb \u00e7rregullta<\/em><\/p><\/blockquote>\n<p>Nd\u00ebrkoh\u00eb, nj\u00eb grup i tret\u00eb besonte se gj\u00ebja e par\u00eb q\u00eb do t\u00eb shfaqej ishte nj\u00eb en\u00eb p\u00ebr molekulat ky\u00e7e, p\u00ebr t&#8217;i mbajtur ata t\u00eb lundronin. &#8220;<em>Sektorializimi duhet t\u00eb ket\u00eb ardhur m\u00eb par\u00eb, sepse nuk ka kuptim t\u00eb b\u00ebjm\u00eb metabolizmin, n\u00ebse nuk jeni t\u00eb ndar\u00eb n\u00eb pjes\u00eb<\/em>&#8220;, thot\u00eb Sutherland. Me fjal\u00eb t\u00eb tjera, duhet t\u00eb kishte nj\u00eb qeliz\u00eb &#8211; si\u00e7 theksoi Oparin dhe Haldane disa dekada m\u00eb par\u00eb &#8211; <a href=\"https:\/\/link.springer.com\/article\/10.1023%2FA%3A1006746807104\" target=\"_blank\" rel=\"noopener noreferrer\">ndoshta t\u00eb mbyllur nga nj\u00eb membran\u00eb e yndyrave t\u00eb thjeshta dhe t\u00eb lipideve<\/a>.<\/p>\n<p>T\u00eb tre idet\u00eb mor\u00ebn adhuruesit e tyre dhe kan\u00eb mbijetuar deri n\u00eb dit\u00ebt e sotme. Shkenc\u00ebtar\u00ebt jan\u00eb b\u00ebr\u00eb tep\u00ebr t\u00eb p\u00ebrkushtuar ndaj k\u00ebtyre ideve p\u00ebr kafsh\u00ebt, ndonj\u00ebher\u00eb edhe n\u00eb m\u00ebnyr\u00eb t\u00eb verb\u00ebr.<\/p>\n<p>Si rezultat, takimet shkencore mbi origjin\u00ebn e jet\u00ebs kan\u00eb qen\u00eb shpesh \u00e7\u00ebshtje t\u00eb \u00e7rregullta dhe gazetar\u00ebt q\u00eb e mbulojn\u00eb k\u00ebt\u00eb tem\u00eb d\u00ebgjojn\u00eb rregullisht nj\u00eb shkenc\u00ebtar n\u00eb nj\u00eb kamp, \u200b\u200bse idet\u00eb q\u00eb dalin nga kampet e tjera jan\u00eb budallall\u00ebqe ose m\u00eb keq.<\/p>\n<p>N\u00eb saj\u00eb t\u00eb Orgel, ideja q\u00eb jeta filloi me ARN dhe gjenetik\u00ebn u ngrit\u00ebn n\u00eb fillim t\u00eb fillimit. Pastaj erdh\u00ebn vitet 1980, dhe nj\u00eb zbulim befasues, q\u00eb duket se e konfirmonte m\u00eb shum\u00eb k\u00ebt\u00eb.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"ARN mund t\u00eb jet\u00eb \u00e7el\u00ebsi i jet\u00ebs\" src=\"http:\/\/fjala.info\/2018\/p04cl4d4.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>ARN mund t\u00eb jet\u00eb \u00e7el\u00ebsi i fillimit t\u00eb jet\u00ebs<\/em> (Credit: Equinox Graphics Ltd)<\/p>\n<\/blockquote>\n<p><strong>Kapitulli 3. K\u00ebrkimi p\u00ebr replikatorin e par\u00eb<\/strong><\/p>\n<p>Pas viteve 1960, shkenc\u00ebtar\u00ebt n\u00eb p\u00ebrpjekjen p\u00ebr t\u00eb kuptuar origjin\u00ebn e jet\u00ebs u ndan\u00eb n\u00eb tre grupe. Disa ishin t\u00eb bindur se jeta filloi me formimin e versioneve primitive t\u00eb qelizave biologjike. T\u00eb tjer\u00eb mendonin se hapi i par\u00eb ishte nj\u00eb sistem metabolik, nd\u00ebrsa t\u00eb tjer\u00ebt p\u00ebrqendroheshin n\u00eb r\u00ebnd\u00ebsin\u00eb e gjenetik\u00ebs dhe p\u00ebrs\u00ebritjes. Ky grup i fundit filloi t\u00eb p\u00ebrpiqej t\u00eb kuptonte se \u00e7far\u00eb mund t\u00eb dukej si <em>p\u00ebrs\u00ebrit\u00ebsi i par\u00eb<\/em> &#8211; me fokus n\u00eb iden\u00eb se ishte b\u00ebr\u00eb nga ARN.<\/p>\n<p>Q\u00eb n\u00eb fillim t\u00eb viteve 1960, shkenc\u00ebtar\u00ebt kishin arsye p\u00ebr t\u00eb menduar se ARN ishte burimi i gjith\u00eb jet\u00ebs.<\/p>\n<p>N\u00eb m\u00ebnyr\u00eb t\u00eb ve\u00e7ant\u00eb, ARN mund t\u00eb b\u00ebj\u00eb di\u00e7ka q\u00eb ADN-ja nuk mund ta b\u00ebj\u00eb. Kjo \u00ebsht\u00eb nj\u00eb molekul\u00eb e vetme e bllokuar, k\u00ebshtu q\u00eb ndryshe nga ADN-ja e ngurt\u00eb, me dy b\u00ebrthama, mund t\u00eb del n\u00eb nj\u00eb gam\u00eb t\u00eb formave t\u00eb ndryshme.<\/p>\n<blockquote><p><em>Ju nuk mund t\u00eb jetoni pa enzimat<\/em><\/p><\/blockquote>\n<p>Palosja origjinale e ARN-s\u00eb dukej mjaft e ngjashme me m\u00ebnyr\u00ebn se si sillen proteinat. Proteinat jan\u00eb gjithashtu n\u00eb thelb fusha t\u00eb gjata &#8211; t\u00eb b\u00ebra nga aminoacidet n\u00eb vend t\u00eb nukleotideve &#8211; dhe kjo i lejon ato t\u00eb nd\u00ebrtojn\u00eb struktura t\u00eb p\u00ebrpunuara.<\/p>\n<p>Ky \u00ebsht\u00eb \u00e7el\u00ebsi i aft\u00ebsis\u00eb m\u00eb t\u00eb mahnitshme t\u00eb proteinave. Disa prej tyre mund t\u00eb p\u00ebrshpejtojn\u00eb, ose &#8220;katalizojn\u00eb&#8221; reagimet kimike. K\u00ebto proteina njihen si enzima.<\/p>\n<p>Shum\u00eb enzima gjenden n\u00eb zorr\u00ebt tuaja, ku ata thyejn\u00eb molekulat komplekse nga ushqimi juaj n\u00eb t\u00eb thjeshta si sheqernat, q\u00eb mund t\u00eb p\u00ebrdorin qelizat tuaja. Ju nuk mund t\u00eb jetoni pa enzima.<\/p>\n<p>Leslie Orgel dhe Francis Crick kishin dyshime. N\u00ebse ARN mund t\u00eb dale si nj\u00eb protein\u00eb, ndoshta ajo mund t\u00eb formoj\u00eb enzim\u00eb. N\u00ebse kjo do t\u00eb ishte e v\u00ebrtet\u00eb, ARN do t\u00eb mund t\u00eb ishte molekula origjinale &#8211; dhe shum\u00eb e shum\u00ebllojshme &#8211; duke ruajtur informacionin si ADN-ja tani dhe duke katalizuar reagimet si disa proteina.<\/p>\n<p>Kjo ishte nj\u00eb ide e mir\u00eb, por nuk do t\u00eb kishte prova p\u00ebr m\u00eb shum\u00eb se nj\u00eb dekad\u00eb.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Thomas Cech m\u00eb 2007\" src=\"http:\/\/fjala.info\/2018\/p04dbcdt.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Thomas Cech m\u00eb 2007<\/em> (Credit: Douglas A. Lockard, CC by 3.0)<\/p>\n<\/blockquote>\n<p><a href=\"https:\/\/www.colorado.edu\/lab\/cech\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Thomas Cech<\/strong><\/a> ka lindur dhe \u00ebsht\u00eb rritur n\u00eb Iowa. Si f\u00ebmij\u00eb ai ishte i hipnotizuar nga shk\u00ebmbinj dhe minerale. N\u00eb koh\u00ebn kur ishte n\u00eb shkoll\u00eb t\u00eb mesme, ai ishte duke vizituar universitetin lokal dhe duke trokitur n\u00eb dyert e gjeolog\u00ebve, duke k\u00ebrkuar t\u00eb shoh\u00eb modele t\u00eb strukturave minerale.<\/p>\n<p>Por ai p\u00ebrfundimisht u p\u00ebrcaktua duke u b\u00ebr\u00eb nj\u00eb biokimist, duke u fokusuar n\u00eb ARN.<\/p>\n<blockquote><p><em>Tani nocioni se jeta filloi me ARN dukej premtues<\/em><\/p><\/blockquote>\n<p>N\u00eb fillim t\u00eb viteve 1980, Cech dhe koleg\u00ebt e tij n\u00eb Universitetin e Kolorados Boulder po studionin nj\u00eb organiz\u00ebm me nj\u00eb qeliz\u00eb t\u00eb quajtur <em>Tetrahymena thermophila<\/em>. Pjes\u00eb e makineris\u00eb s\u00eb tij qelizore p\u00ebrfshijn\u00eb vargjet e ARN. Cech zbuloi se nj\u00eb pjes\u00eb e ve\u00e7ant\u00eb e ARN-s\u00eb nganj\u00ebher\u00eb u shk\u00ebput nga pjesa tjet\u00ebr, sikur di\u00e7ka ta kishte prer\u00eb me g\u00ebrsh\u00ebr\u00eb.<\/p>\n<p>Kur ekipi hoqi t\u00eb gjitha enzimat dhe molekulat e tjera q\u00eb mund t\u00eb vepronin si g\u00ebrsh\u00ebr\u00eb molekulare, ARN vazhdoi ta b\u00ebj\u00eb k\u00ebt\u00eb. Ata kishin zbuluar <a href=\"http:\/\/www.cell.com\/cell\/pdf\/0092-8674(82)90414-7.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">enzim\u00ebn e par\u00eb t\u00eb ARN-s\u00eb<\/a>: nj\u00eb pjes\u00eb e shkurt\u00ebr e ARN-s\u00eb, e cila ishte n\u00eb gjendje t\u00eb shk\u00ebpus\u00eb veten nga pjesa m\u00eb e madhe, q\u00eb ishte pjes\u00eb e saj.<\/p>\n<p>Cech i publikoi rezultatet n\u00eb 1982. Nj\u00eb vit m\u00eb pas, <a href=\"http:\/\/www.cell.com\/cell\/pdf\/0092-8674(83)90117-4.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">nj\u00eb grup tjet\u00ebr gjeti nj\u00eb enzim\u00eb t\u00eb dyt\u00eb t\u00eb ARN-s\u00eb<\/a> &#8211; ose &#8220;ribozim\u00ebn&#8221;, ashtu si\u00e7 u quajt.<\/p>\n<p>Gjetja e dy enzimave t\u00eb ARN, n\u00eb nj\u00eb vazhdim\u00ebsi t\u00eb shpejt\u00eb, sugjeroi se ka pasur shum\u00eb m\u00eb tep\u00ebr atje. Tani nocioni se jeta filloi me ARN ishte nj\u00eb k\u00ebrkim premtues.<\/p>\n<p>Zbuloni m\u00eb shum\u00eb rreth ARN-s\u00eb n\u00eb k\u00ebt\u00eb video:<br \/>\n(<em>videon shikojeni n\u00eb <a href=\"http:\/\/www.bbc.com\/earth\/story\/20161026-the-secret-of-how-life-on-earth-began\" target=\"_blank\" rel=\"noopener noreferrer\">shkrimin origjinal<\/a>, pasi nuk mund\u00ebm ta fusnim k\u00ebtu<\/em>)<\/p>\n<p>Do t\u00eb ishte <a href=\"https:\/\/www.nobelprize.org\/nobel_prizes\/chemistry\/laureates\/1980\/gilbert-bio.html\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Walter Gilbert<\/strong><\/a> i Universitetit t\u00eb Harvardit n\u00eb Kembrixh, Massachusetts, i cili i dha ide nj\u00eb emri. Nj\u00eb fizikan q\u00eb ishte hipnotizuar nga biologjia molekulare, Gilbert do t\u00eb ishte gjithashtu nj\u00eb nga avokat\u00ebt e hersh\u00ebm t\u00eb <a href=\"https:\/\/www.nature.com\/articles\/349099a0\" target=\"_blank\" rel=\"noopener noreferrer\">sekuencimit t\u00eb gjenomit njer\u00ebzor<\/a>.<\/p>\n<blockquote><p><em>ARN Bot\u00ebrore \u00ebsht\u00eb nj\u00eb m\u00ebnyr\u00eb elegante p\u00ebr t\u00eb krijuar jet\u00eb komplekse nga e para<\/em><\/p><\/blockquote>\n<p>Duke shkruar n\u00eb Nature n\u00eb vitin 1986, Gilbert propozoi q\u00eb jeta filloi n\u00eb &#8220;<em>ARN Bot\u00ebrore<\/em>&#8220;.<\/p>\n<p>Faza e par\u00eb e evolucionit, tha Gilbert, p\u00ebrb\u00ebhej nga &#8220;<em>molekulat e ARN (RNA n\u00eb anglisht), q\u00eb kryen aktivitetet katalitike t\u00eb nevojshme p\u00ebr t&#8217;u mbledhur nga nj\u00eb sup\u00eb nukleotide<\/em>&#8220;. Duke i prer\u00eb dhe ngjitur copa t\u00eb ndryshme t\u00eb ARN-s\u00eb s\u00eb bashku, molekulat e ARN mund t\u00eb krijojn\u00eb sekuenca gjithnj\u00eb e m\u00eb t\u00eb dobishme. P\u00ebrfundimisht gjet\u00ebn nj\u00eb m\u00ebnyr\u00eb p\u00ebr t\u00eb b\u00ebr\u00eb proteina dhe enzima t\u00eb proteinave, t\u00eb cilat u treguan kaq t\u00eb dobishme saq\u00eb n\u00eb mas\u00eb t\u00eb madhe z\u00ebvend\u00ebsuan versionet e ARN-s\u00eb dhe krijuan jet\u00ebn, si\u00e7 e njohim sot.<\/p>\n<p>ARN Bot\u00ebrore \u00ebsht\u00eb nj\u00eb m\u00ebnyr\u00eb elegante p\u00ebr t\u00eb b\u00ebr\u00eb jet\u00eb komplekse nga e para. N\u00eb vend q\u00eb t\u00eb mb\u00ebshtetet n\u00eb formimin e nj\u00ebkohsh\u00ebm t\u00eb dhjetra molekulave biologjike nga sup\u00eb primordiale, nj\u00eb molekul\u00eb <em>Jack-of-all-trades<\/em> mund t\u00eb b\u00ebj\u00eb pun\u00ebn e t\u00eb gjith\u00eb atyre.<\/p>\n<p>N\u00eb vitin 2000, hipotez\u00ebs s\u00eb ARN-s\u00eb Bot\u00ebrore iu dhurua nj\u00eb pjes\u00eb dramatike e provave mb\u00ebshtet\u00ebse.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Ribozomi b\u00ebn proteina\" src=\"http:\/\/fjala.info\/2018\/p04cl9dg.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Ribozomi b\u00ebn proteina<\/em> (Credit: Laguna Design\/Science Photo Library)<\/p>\n<\/blockquote>\n<p><a href=\"http:\/\/bbs.yale.edu\/people\/thomas_steitz-1.profile\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Thomas Steitz<\/strong><\/a> kishte kaluar 30 vjet duke studiuar strukturat e molekulave n\u00eb qelizat e gjalla. N\u00eb vitet 1990 ai mori sfid\u00ebn e tij m\u00eb t\u00eb madhe: duke zbuluar struktur\u00ebn e ribozom\u00ebs.<\/p>\n<blockquote><p><em>Fakti q\u00eb kjo makin\u00eb esenciale u bazua n\u00eb ARN e b\u00ebri ARN bot\u00ebrore edhe m\u00eb t\u00eb besueshme<\/em><\/p><\/blockquote>\n<p>\u00c7do qeliz\u00eb e gjall\u00eb ka nj\u00eb ribozom\u00eb. Kjo molekul\u00eb e madhe lexon udh\u00ebzime nga ARN dhe vargjet s\u00eb bashku aminoacidet p\u00ebr t\u00eb b\u00ebr\u00eb proteina. Ribozomet n\u00eb qelizat tuaja nd\u00ebrtojn\u00eb pjes\u00ebn m\u00eb t\u00eb madhe t\u00eb trupit tuaj.<\/p>\n<p>Ribozomi ishte i njohur p\u00ebr t\u00eb p\u00ebrmbajtur ARN. Por n\u00eb vitin 2000 ekipi i Steitz-it prodhoi <a href=\"http:\/\/science.sciencemag.org\/content\/289\/5481\/920\" target=\"_blank\" rel=\"noopener noreferrer\">nj\u00eb imazh t\u00eb detajuar t\u00eb struktur\u00ebs s\u00eb ribozom\u00ebs<\/a>, gj\u00eb q\u00eb tregoi se <a href=\"http:\/\/science.sciencemag.org\/content\/289\/5481\/878\" target=\"_blank\" rel=\"noopener noreferrer\">ARN ishte thelbi katalitik i ribozom\u00ebs<\/a>.<\/p>\n<p>Kjo ishte kritike, sepse ribosomi \u00ebsht\u00eb aq themelor p\u00ebr jet\u00ebn, dhe kaq i lasht\u00eb. Fakti q\u00eb kjo makin\u00eb esenciale u bazua n\u00eb ARN e b\u00ebri ARN bot\u00ebrore edhe m\u00eb t\u00eb besueshme.<\/p>\n<p>P\u00ebrkrah\u00ebsit e ARN-s\u00eb bot\u00ebrore ishin t\u00eb ekstazuar nga zbulimi dhe n\u00eb vitin 2009 Steitz do t\u00eb b\u00ebhej pjes\u00eb e <a href=\"https:\/\/www.nobelprize.org\/nobel_prizes\/chemistry\/laureates\/2009\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u00e7mimit Nobel<\/a>. Por q\u00eb at\u00ebher\u00eb, dyshimet jan\u00eb rikthyer.<\/p>\n<p>Q\u00eb nga fillimi, kishte dy probleme me iden\u00eb Bot\u00ebrore t\u00eb ARN-s\u00eb. A mundet ARN t\u00eb kryej\u00eb t\u00eb gjitha funksionet e jet\u00ebs n\u00eb vetvete? Dhe a mund t\u00eb jet\u00eb formuar n\u00eb Tok\u00ebn e hershme?<\/p>\n<blockquote><p><em>Ata vendos\u00ebn t\u00eb b\u00ebnin nj\u00eb ARN t\u00eb vet\u00eb-p\u00ebrs\u00ebritur p\u00ebr veten e tyre<\/em><\/p><\/blockquote>\n<p>Kan\u00eb kaluar 30 vjet q\u00eb kur Gilbert-i ka vendosur stacionin p\u00ebr ARN-n\u00eb bot\u00ebrore, dhe ende nuk kemi prova t\u00eb forta q\u00eb ARN mund t&#8217;i b\u00ebj\u00eb t\u00eb gjitha gj\u00ebrat, q\u00eb k\u00ebrkon teoria prej saj. Kjo \u00ebsht\u00eb nj\u00eb molekul\u00eb e dobishme e vog\u00ebl, por mund t\u00eb mos jet\u00eb mjaft e dobishme.<\/p>\n<p>Nj\u00eb detyr\u00eb u dallua. N\u00ebse jeta filloi me nj\u00eb molekul\u00eb ARN, ajo ARN duhet t\u00eb ket\u00eb qen\u00eb n\u00eb gjendje t\u00eb b\u00ebj\u00eb kopje t\u00eb vetes: duhet t\u00eb ket\u00eb qen\u00eb e vet\u00eb-p\u00ebrs\u00ebritur.<\/p>\n<p>Por asnj\u00eb ARN e njohur nuk mund t\u00eb p\u00ebrs\u00ebritet. Nuk mundet as ADN. Ajo merr nj\u00eb batalion t\u00eb enzimave dhe molekulave t\u00eb tjera p\u00ebr t\u00eb nd\u00ebrtuar nj\u00eb kopje t\u00eb saj, t\u00eb nj\u00eb cope ARN ose ADN.<\/p>\n<p>Pra, n\u00eb fund t\u00eb viteve 1980, disa biolog\u00eb filluan nj\u00eb k\u00ebrkim donkishotesk. Ata vendos\u00ebn p\u00ebr t\u00eb b\u00ebr\u00eb nj\u00eb ARN t\u00eb vet\u00eb-p\u00ebrs\u00ebritur p\u00ebr veten e tyre.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Jack Szostak\" src=\"http:\/\/fjala.info\/2018\/p04cl31q.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><i>Jack Szostak<\/i> (Credit: Detlev van Ravenswaay\/Science Photo Library)<\/p>\n<\/blockquote>\n<p><a href=\"http:\/\/molbio.mgh.harvard.edu\/szostakweb\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Jack Szostak<\/strong><\/a> i Shkoll\u00ebs Mjek\u00ebsore t\u00eb Harvardit ishte nj\u00eb nga t\u00eb par\u00ebt q\u00eb p\u00ebrfshihej. Si f\u00ebmij\u00eb ai ishte i hipnotizuar kaq shum\u00eb nga kimia, aq sa kishte nj\u00eb laborator n\u00eb bodrumin e tij. Me nj\u00eb shp\u00ebrfillje t\u00eb shk\u00eblqyer p\u00ebr sigurin\u00eb e tij, <a href=\"https:\/\/www.nobelprize.org\/nobel_prizes\/medicine\/laureates\/2009\/szostak-bio.html\" target=\"_blank\" rel=\"noopener noreferrer\">ai dikur nisi nj\u00eb shp\u00ebrthim<\/a>, q\u00eb t\u00eb fuste nj\u00eb tub qelqi n\u00eb tavan.<\/p>\n<blockquote><p><em>Ata kishin treguar se enzimat ARN mund t\u00eb jen\u00eb me t\u00eb v\u00ebrtet\u00eb t\u00eb fuqishme<\/em><\/p><\/blockquote>\n<p>N\u00eb fillim t\u00eb viteve 1980, Szostak ndihmoi p\u00ebr t\u00eb treguar se si gjenet tona mbrojn\u00eb veten kund\u00ebr procesit t\u00eb plakjes. Ky hulumtim i hersh\u00ebm p\u00ebrfundimisht do e b\u00ebnte at\u00eb pjes\u00eb t\u00eb <a href=\"https:\/\/www.nobelprize.org\/nobel_prizes\/medicine\/laureates\/2009\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u00e7mimit Nobel<\/a>.<\/p>\n<p>Por shpejt ai u hipnotizua nga enzimat e ARN t\u00eb Cech. &#8220;<em>Mendova se puna ishte v\u00ebrtet e ftoht\u00eb<\/em>,&#8221; thot\u00eb ai. &#8220;<em>N\u00eb parim, mund t\u00eb ket\u00eb nj\u00eb mund\u00ebsi p\u00ebr ARN-n\u00eb p\u00ebr t\u00eb katalizuar replikimin (p\u00ebrs\u00ebritjen) e vet<\/em>.&#8221;<\/p>\n<p>N\u00eb vitin 1988, Cech zbuloi <a href=\"http:\/\/science.sciencemag.org\/content\/239\/4846\/1412\" target=\"_blank\" rel=\"noopener noreferrer\">nj\u00eb enzim\u00eb ARN, q\u00eb mund t\u00eb nd\u00ebrtonte nj\u00eb molekul\u00eb t\u00eb shkurt\u00ebr ARN me rreth 10 nukleotide<\/a>. Szostak u nis p\u00ebr t\u00eb p\u00ebrmir\u00ebsuar zbulimin, duke evoluar enzimat e reja t\u00eb ARN-s\u00eb n\u00eb laborator. Ekipi i tij krijoi nj\u00eb grup sekuencash t\u00eb rast\u00ebsishme dhe i testoi ato p\u00ebr t\u00eb par\u00eb se cilat treguan aktivitetin katalitik. Pastaj mor\u00ebn ato sekuenca, i rrafshuan dhe u testuan s\u00ebrish.<\/p>\n<p>Pas 10 raundeve t\u00eb k\u00ebsaj, Szostak <a href=\"http:\/\/science.sciencemag.org\/content\/261\/5127\/1411\" target=\"_blank\" rel=\"noopener noreferrer\">kishte prodhuar nj\u00eb enzim\u00eb ARN, q\u00eb b\u00ebri nj\u00eb reagim shtat\u00eb milion\u00eb her\u00eb m\u00eb shpejt se sa natyrisht<\/a>. Ata treguan se enzimat ARN mund t\u00eb jen\u00eb me t\u00eb v\u00ebrtet\u00eb t\u00eb fuqishme. Por enzimat e tyre nuk mund t\u00eb kopjojn\u00eb vetveten, madje as t&#8217;i afrohen. Szostak kishte goditur nj\u00eb mur.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"ARN nuk mund t\u00eb jet\u00eb p\u00ebr fillimin e jet\u00ebs\" src=\"http:\/\/fjala.info\/2018\/p04dbh7k.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>ARN nuk mund t\u00eb jet\u00eb n\u00eb gjendje p\u00ebr pun\u00ebn e fillimit t\u00eb jet\u00ebs<\/em><br \/>\n(Credit: Science Photo Library\/Alamy)<\/p>\n<\/blockquote>\n<p>P\u00ebrparimi i ardhsh\u00ebm i madh erdhi n\u00eb vitin 2001 nga ish-studenti e Szostak, <a href=\"http:\/\/bartellab.wi.mit.edu\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>David Bartel<\/strong><\/a>, nga Instituti i Teknologjis\u00eb i Masa\u00e7usetsit n\u00eb Kembrixh. Bartel b\u00ebri nj\u00eb enzim\u00eb ARN t\u00eb quajtur <strong>R18<\/strong>, q\u00eb mund t\u00eb shtonte nukleotide t\u00eb reja n\u00eb nj\u00eb varg t\u00eb ARN-s\u00eb, bazuar n\u00eb nj\u00eb model ekzistues. Me fjal\u00eb t\u00eb tjera, nuk ishte vet\u00ebm duke shtuar nukleotide t\u00eb rastit: ishte kopjimi i sakt\u00eb i nj\u00eb sekuence.<\/p>\n<p>Kjo ende nuk ishte nj\u00eb vet\u00eb-rip\u00ebrt\u00ebrit\u00ebs, por ishte duke u shkuar drejt saj. R18 p\u00ebrb\u00ebhej nga nj\u00eb varg prej 189 nukleotidesh dhe <a href=\"http:\/\/science.sciencemag.org\/content\/292\/5520\/1319\" target=\"_blank\" rel=\"noopener noreferrer\">mund t\u00eb shtonte me besueshm\u00ebri 11 nukleotide n\u00eb nj\u00eb varg t\u00eb ARN-s\u00eb<\/a>: 6% t\u00eb gjat\u00ebsis\u00eb s\u00eb vet. Shpresa ishte se disa shkulje do t\u00eb lejojn\u00eb, q\u00eb ajo t\u00eb b\u00ebj\u00eb nj\u00eb varg prej 189 nukleotidesh t\u00eb gjat\u00eb &#8211; aq t\u00eb gjat\u00eb sa veten.<\/p>\n<blockquote><p><em>ARN nuk duket s\u00eb \u00ebsht\u00eb p\u00ebr pun\u00ebn e fillimit t\u00eb jet\u00ebs<\/em><\/p><\/blockquote>\n<p>P\u00ebrpjekja m\u00eb e mir\u00eb erdhi n\u00eb vitin 2011 nga <a href=\"https:\/\/www2.mrc-lmb.cam.ac.uk\/groups\/ph1\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Philipp Holliger<\/strong><\/a> i Laboratorit t\u00eb Biologjis\u00eb Molekulare n\u00eb Kembrixh, Britani t\u00eb Madhe. Ekipi i tij krijoi nj\u00eb <a href=\"http:\/\/science.sciencemag.org\/content\/332\/6026\/209\" target=\"_blank\" rel=\"noopener noreferrer\">R18 t\u00eb modifikuar t\u00eb quajtur <em>tC19Z<\/em><\/a>, i cili kopjon sekuencat deri n\u00eb 95 nukleotide. Kjo \u00ebsht\u00eb 48% e gjat\u00ebsis\u00eb s\u00eb vet: m\u00eb shum\u00eb se R18, por jo 100% e nevojshme.<\/p>\n<p>Nj\u00eb qasje alternative \u00ebsht\u00eb paraqitur nga <a href=\"https:\/\/www.scripps.edu\/research\/faculty\/joyce\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Gerald Joyce<\/strong><\/a> dhe Tracey Lincoln nga Instituti i K\u00ebrkimeve t\u00eb Scripps n\u00eb La Jolla, California. N\u00eb vitin 2009 ata krijuan <a href=\"http:\/\/science.sciencemag.org\/content\/323\/5918\/1229\" target=\"_blank\" rel=\"noopener noreferrer\">nj\u00eb enzim\u00eb ARN q\u00eb p\u00ebrs\u00ebritet n\u00eb m\u00ebnyr\u00eb indirekte<\/a>.<\/p>\n<p>Enzima e tyre bashkohet s\u00eb bashku n\u00eb dy pjes\u00eb t\u00eb shkurtra t\u00eb ARN-s\u00eb, p\u00ebr t\u00eb krijuar nj\u00eb enzim\u00eb t\u00eb dyt\u00eb. Kjo pastaj bashkohet s\u00eb bashku n\u00eb dy pjes\u00eb t\u00eb tjera t\u00eb ARN-s\u00eb p\u00ebr t\u00eb rikrijuar enzim\u00ebn origjinale.<\/p>\n<p>Ky cik\u00ebl i thjesht\u00eb mund t\u00eb vazhdoj\u00eb pafund\u00ebsisht, duke pasur parasysh l\u00ebnd\u00ebt e para. Por enzimat funksionuan vet\u00ebm n\u00ebse u jepeshin fillesat e duhura t\u00eb ARN-s\u00eb, t\u00eb cilat Joyce dhe Lincoln duhej t&#8217;i b\u00ebnin.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Molekulat e jet\u00ebs\" src=\"http:\/\/fjala.info\/2018\/p04dbhrf.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Si mund t\u00eb formoheshin molekulat e jet\u00ebs diku si k\u00ebtu?<\/em><br \/>\n(Credit: MasPix\/Alamy)<\/p>\n<\/blockquote>\n<p>P\u00ebr shum\u00eb shkenc\u00ebtar\u00eb q\u00eb jan\u00eb skeptik\u00eb rreth Bot\u00ebs s\u00eb ARN-s\u00eb, mungesa e nj\u00eb ARN-je t\u00eb vet\u00eb-p\u00ebrs\u00ebritur \u00ebsht\u00eb nj\u00eb problem fatal me k\u00ebt\u00eb ide. ARN nuk duket t\u00eb ket\u00eb pasur pun\u00eb me fillimin e jet\u00ebs.<\/p>\n<blockquote><p><em>Ndoshta ekzistonte nj\u00eb lloj tjet\u00ebr molekule n\u00eb Tok\u00ebn e hershme<\/em><\/p><\/blockquote>\n<p>Rasti \u00ebsht\u00eb gjithashtu dob\u00ebsuar nga d\u00ebshtimi i kimist\u00ebve p\u00ebr t\u00eb b\u00ebr\u00eb ARN-n\u00eb nga zeroja. Ajo duket si nj\u00eb molekul\u00eb e thjesht\u00eb n\u00eb krahasim me ADN-n\u00eb, por ARN ka provuar t\u00eb jet\u00eb jasht\u00ebzakonisht e v\u00ebshtir\u00eb p\u00ebr t&#8217;u b\u00ebr\u00eb.<\/p>\n<p>Problemi \u00ebsht\u00eb sheqeri dhe baza q\u00eb e p\u00ebrb\u00ebjn\u00eb secil\u00ebn nukleotid. \u00cbsht\u00eb e mundur q\u00eb secila prej tyre t\u00eb b\u00ebhet individualisht, por t\u00eb dyja refuzojn\u00eb me kok\u00ebfort\u00ebsi t\u00eb lidhen s\u00eb bashku.<\/p>\n<p>Ky problem ishte tashm\u00eb i qart\u00eb nga fillimi i viteve 1990. I la shum\u00eb biolog\u00eb me nj\u00eb dyshim bezdissh\u00ebm q\u00eb hipoteza e ARN-s\u00eb, ndon\u00ebse e past\u00ebr, nuk mund t\u00eb ishte fare e drejt\u00eb.<\/p>\n<p>N\u00eb vend t\u00eb k\u00ebsaj, ndoshta ekzistonte nj\u00eb lloj tjet\u00ebr molekule n\u00eb Tok\u00ebn e hershme: di\u00e7ka m\u00eb e thjesht\u00eb se ARN, e cila me t\u00eb v\u00ebrtet\u00eb mund t\u00eb mblidhej nga supa primordiale dhe t\u00eb fillonte vet\u00eb-p\u00ebrs\u00ebritjen. Kjo mund t\u00eb ket\u00eb ardhur si fillim dhe pastaj ajo \u00e7oi n\u00eb ARN, ADN dhe pjes\u00ebn tjet\u00ebr.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"ADN n\u00eb Tok\u00ebn e hershme\" src=\"http:\/\/fjala.info\/2018\/p04dbgn1.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>ADN mund t\u00eb jet\u00eb p\u00ebrpjekur p\u00ebr t&#8217;u formuar n\u00eb Tok\u00ebn e hershme<\/em><br \/>\n(Credit: Science Photo Library\/Alamy)<\/p>\n<\/blockquote>\n<p>N\u00eb vitin 1991, <a href=\"http:\/\/icmm.ku.dk\/english\/research-groups\/pe-nielsen-group\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Peter Nielsen<\/strong><\/a> nga Universiteti i Kopenhag\u00ebs n\u00eb Danimark\u00eb doli me nj\u00eb kandidat p\u00ebr replicatorin primordial.<\/p>\n<p>Ishte n\u00eb thelb nj\u00eb version i ADN-s\u00eb shum\u00eb i modifikuar. Nielsen mbajti bazat e nj\u00ebjta &#8211; duke u ngjitur me A (adenin\u00eb), T (timin\u00eb), C (citozin\u00eb) dhe G (guanin\u00eb) t\u00eb gjetur n\u00eb ADN &#8211; por e b\u00ebri shtyll\u00ebn kurrizore t\u00eb molekulave t\u00eb quajtura <em>polyamides<\/em> n\u00eb vend t\u00eb sheqernave q\u00eb gjenden n\u00eb ADN. Ai e quajti molekul\u00ebn e re <a href=\"http:\/\/science.sciencemag.org\/content\/254\/5037\/1497\" target=\"_blank\" rel=\"noopener noreferrer\"><em>acidin nukleik poliamid<\/em><\/a>, ose PNA. Konfuzionalisht, ajo q\u00eb at\u00ebher\u00eb \u00ebsht\u00eb b\u00ebr\u00eb e njohur si acidi nukleik peptidik.<\/p>\n<blockquote><p><em>PNA, ndryshe nga ARN, mund t\u00eb jet\u00eb formuar leht\u00eb n\u00eb Tok\u00ebn e hershme<\/em><\/p><\/blockquote>\n<p>PNA nuk \u00ebsht\u00eb gjetur kurr\u00eb n\u00eb natyr\u00eb. Por sillet shum\u00eb si ADN-ja. Nj\u00eb varg i PNA-s\u00eb mund edhe t\u00eb z\u00ebr\u00eb vendin e nj\u00eb prej fillesave n\u00eb nj\u00eb molekul\u00eb t\u00eb ADN-s\u00eb, me bazat komplementare q\u00eb bashkohen normalisht. P\u00ebr m\u00eb tep\u00ebr, PNA mund t\u00eb mb\u00ebshtillet n\u00eb nj\u00eb spirale t\u00eb dyfisht\u00eb, ashtu si ADN-ja.<\/p>\n<p>Stanley Miller u intrigua. Skeptik i thell\u00eb p\u00ebr Bot\u00ebn e ARN-s\u00eb, dyshonte se <a href=\"https:\/\/www.nature.com\/articles\/nsb0397-167.epdf\" target=\"_blank\" rel=\"noopener noreferrer\">PNA mund t\u00eb ishte nj\u00eb kandidat m\u00eb i besuesh\u00ebm p\u00ebr materialin e par\u00eb gjenetik<\/a>.<\/p>\n<p>N\u00eb vitin 2000 ai prodhoi disa prova t\u00eb forta. N\u00eb at\u00eb koh\u00eb ai ishte 70 vje\u00e7 dhe kishte vuajtur si fillim <a href=\"http:\/\/ucsdnews.ucsd.edu\/archive\/newsrel\/science\/05-07OriginofLifeKM-.asp\" target=\"_blank\" rel=\"noopener noreferrer\">nga nj\u00eb s\u00ebr\u00eb goditjesh dob\u00ebsuese<\/a> q\u00eb do ta linin t\u00eb mbyllur n\u00eb nj\u00eb sht\u00ebpi p\u00ebrkujdesi, por nuk ishte mbyllur fare. Ai p\u00ebrs\u00ebriti eksperimentin e tij klasik, t\u00eb cilin e diskutuam n\u00eb kapitullin e par\u00eb, k\u00ebt\u00eb her\u00eb duke p\u00ebrdorur <em>metanin<\/em>, <em>azotin<\/em>, <em>amoniakun<\/em> dhe <em>ujin<\/em> &#8211; dhe mori shtyll\u00ebn poliamide t\u00eb PNA.<\/p>\n<p>Kjo sugjeroi q\u00eb PNA, ndryshe nga ARN, mund t\u00eb ishte formuar leht\u00eb n\u00eb Tok\u00ebn e hershme.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"ADN n\u00eb Tok\u00ebn e hershme\" src=\"http:\/\/fjala.info\/2018\/p04cl2gn.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Nj\u00eb molekul\u00eb e acidit nukleik threose (TNA)<\/em><br \/>\n(Credit: Alfred Pasieka\/Science Photo Library)<\/p>\n<\/blockquote>\n<p>Kimist\u00eb t\u00eb tjer\u00eb kan\u00eb dal\u00eb me acidet e tyre alternative nukleike.<\/p>\n<blockquote><p><em>Secili prej k\u00ebtyre acideve alternative nukleike ka mb\u00ebshtet\u00ebsit e vet: zakonisht, personin q\u00eb e ka b\u00ebr\u00eb at\u00eb<\/em><\/p><\/blockquote>\n<p>N\u00eb vitin 2000, <a href=\"https:\/\/www.chab.ethz.ch\/en\/the-department\/people\/emeriti\/emeriti-homepages\/albert-eschenmoser.html\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Albert Eschenmoser<\/strong><\/a> b\u00ebri <a href=\"http:\/\/science.sciencemag.org\/content\/290\/5495\/1347\" target=\"_blank\" rel=\"noopener noreferrer\">acidin nukleik threoze<\/a> (TNA). Kjo \u00ebsht\u00eb n\u00eb thelb ADN, por me nj\u00eb sheqer t\u00eb ndrysh\u00ebm n\u00eb boshtin e saj. <a href=\"http:\/\/science.sciencemag.org\/content\/290\/5495\/1306\" target=\"_blank\" rel=\"noopener noreferrer\">Vargjet e TNA-s\u00eb mund t\u00eb \u00e7ift\u00ebzohen p\u00ebr t\u00eb formuar nj\u00eb spirale t\u00eb dyfisht\u00eb<\/a> dhe informacioni mund t\u00eb kopjohet prapa dhe me radh\u00eb nd\u00ebrmjet ARN dhe TNA.<\/p>\n<p>P\u00ebr m\u00eb tep\u00ebr, <a href=\"https:\/\/www.nature.com\/articles\/nchem.1241.epdf\" target=\"_blank\" rel=\"noopener noreferrer\">TNA mund t\u00eb dal\u00eb deri n\u00eb forma komplekse<\/a>, madje edhe t\u00eb lidhet me nj\u00eb protein\u00eb. Kjo l\u00eb t\u00eb kuptohet se TNA mund t\u00eb veproj\u00eb si nj\u00eb enzim\u00eb, ashtu si ARN.<\/p>\n<p>N\u00eb m\u00ebnyr\u00eb t\u00eb ngjashme, n\u00eb vitin 2005 <strong>Eric Meggers<\/strong> b\u00ebri <a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/ja042564z\" target=\"_blank\" rel=\"noopener noreferrer\">acid nukleik t\u00eb glykolit<\/a>, i cili <a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jo201469b\" target=\"_blank\" rel=\"noopener noreferrer\">mund t\u00eb formoj\u00eb struktura spirale<\/a>.<\/p>\n<p>Secili prej k\u00ebtyre acideve alternative nukleike ka mb\u00ebshtet\u00ebsit e vet: zakonisht, personin q\u00eb e ka b\u00ebr\u00eb at\u00eb. Por nuk ka asnj\u00eb gjurm\u00eb t\u00eb tyre n\u00eb natyr\u00eb, k\u00ebshtu q\u00eb n\u00ebse jeta e par\u00eb i ka p\u00ebrdorur ato, n\u00eb nj\u00eb moment duhet t&#8217;i ket\u00eb braktisur plot\u00ebsisht n\u00eb favor t\u00eb ARN-s\u00eb dhe ADN-s\u00eb. Kjo mund t\u00eb jet\u00eb e v\u00ebrtet\u00eb, por nuk ka d\u00ebshmi.<\/p>\n<p>E gjith\u00eb kjo do t\u00eb thoshte se, nga mesi i viteve 2000, mb\u00ebshtet\u00ebsit e ARN Bot\u00ebrore ishin n\u00eb nj\u00eb problem.<\/p>\n<blockquote><p><em>ARN bot\u00ebrore, si\u00e7 ishte, nuk mund t\u00eb ishte e gjith\u00eb e v\u00ebrteta<\/em><\/p><\/blockquote>\n<p>Nga nj\u00ebra an\u00eb, ekzistonin enzimat ARN dhe p\u00ebrfshinin nj\u00eb nga pjes\u00ebt m\u00eb t\u00eb r\u00ebnd\u00ebsishme t\u00eb makineris\u00eb biologjike, ribozomin. Kjo ishte e mir\u00eb.<\/p>\n<p>Por nuk u gjet asnj\u00eb ARN vet\u00eb-p\u00ebrs\u00ebrit\u00ebse dhe askush nuk mund t\u00eb kuptonte se si ARN u formua n\u00eb sup\u00ebn primordiale. Acidet alternative nukleike mund t\u00eb zgjidhin problemin e fundit, por nuk kishte asnj\u00eb prov\u00eb q\u00eb ato ekzistonin n\u00eb natyr\u00eb. Kjo ishte m\u00eb pak e mir\u00eb.<\/p>\n<p>Konkluzioni i qart\u00eb ishte se ARN bot\u00ebrore, e past\u00ebr si\u00e7 ishte, nuk mund t\u00eb ishte e gjith\u00eb e v\u00ebrteta.<\/p>\n<p>Nd\u00ebrkoh\u00eb, nj\u00eb teori rivale ka qen\u00eb vazhdimisht duke mbledhur avull q\u00eb nga vitet 1980. Mb\u00ebshtet\u00ebsit e saj argumentojn\u00eb se jeta nuk filloi me ARN, ose ADN, ose ndonj\u00eb substanc\u00eb tjet\u00ebr gjenetike. N\u00eb vend t\u00eb k\u00ebsaj filloi si nj\u00eb mekaniz\u00ebm p\u00ebr shfryt\u00ebzimin e energjis\u00eb.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Jeta ka nevoj\u00eb p\u00ebr energji\" src=\"http:\/\/fjala.info\/2018\/p04cl36t.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Jeta ka nevoj\u00eb p\u00ebr energji q\u00eb t\u00eb q\u00ebndroj\u00eb e gjall\u00eb<\/em><br \/>\n(Credit: Equinox Graphics Ltd)<\/p>\n<\/blockquote>\n<p><strong>Kapitulli 4. Fuqia nga protonet<\/strong><\/p>\n<p><em>Ne pam\u00eb n\u00eb Kapitullin Dy se si shkenc\u00ebtar\u00ebt u ndan\u00eb n\u00eb tre shkolla t\u00eb mendimit p\u00ebr m\u00ebnyr\u00ebn se si filloi jeta. Nj\u00eb grup ishte i bindur se jeta filloi me nj\u00eb molekul\u00eb ARN, por ata luftuan p\u00ebr t\u00eb shpjeguar se si ARN ose molekulat e ngjashme mund t\u00eb formoheshin spontanisht n\u00eb Tok\u00ebn e hershme dhe pastaj t\u00eb b\u00ebnin kopje t\u00eb vetes. P\u00ebrpjekjet e tyre ishin emocionuese n\u00eb fillim, por n\u00eb fund t\u00eb fundit ishin zhg\u00ebnjyese. Sidoqoft\u00eb, edhe pse ky hulumtim po p\u00ebrparonte, kishte studiues t\u00eb tjer\u00eb t\u00eb origjin\u00ebs, t\u00eb cil\u00ebt ndjeheshin t\u00eb sigurt se jeta filloi n\u00eb nj\u00eb m\u00ebnyr\u00eb krejt\u00ebsisht t\u00eb ndryshme.<\/em><\/p>\n<p>Teoria e ARN-s\u00eb mb\u00ebshtetet n\u00eb nj\u00eb ide t\u00eb thjesht\u00eb: gj\u00ebja m\u00eb e r\u00ebnd\u00ebsishme q\u00eb nj\u00eb organiz\u00ebm i gjall\u00eb mund t\u00eb b\u00ebj\u00eb \u00ebsht\u00eb riprodhimi i vetvetes. Shum\u00eb biolog\u00eb do t\u00eb pajtoheshin me k\u00ebt\u00eb. Nga bakteret n\u00eb balenat blu, t\u00eb gjitha gjallesat p\u00ebrpiqen t\u00eb ken\u00eb pasardh\u00ebs.<\/p>\n<blockquote><p><em>W\u00e4chtersh\u00e4user propozoi q\u00eb organizmat e par\u00eb ishin &#8220;n\u00eb m\u00ebnyr\u00eb drastike t\u00eb ndryshme nga \u00e7do gj\u00eb q\u00eb dim\u00eb&#8221;<\/em><\/p><\/blockquote>\n<p>Megjithat\u00eb, shum\u00eb studiues t\u00eb origjin\u00ebs s\u00eb jet\u00ebs nuk besojn\u00eb se riprodhimi \u00ebsht\u00eb me t\u00eb v\u00ebrtet\u00eb themelor. Para se nj\u00eb organiz\u00ebm t\u00eb riprodhohet, ata thon\u00eb, ai duhet t\u00eb jet\u00eb vet\u00eb-mb\u00ebshtetet. Duhet t\u00eb mbahet gjall\u00eb. Pas t\u00eb gjithave, ju nuk mund t\u00eb keni f\u00ebmij\u00eb, n\u00ebse vdisni s\u00eb pari.<\/p>\n<p>Ne e mbajm\u00eb veten gjall\u00eb duke ngr\u00ebn\u00eb ushqim, nd\u00ebrsa bim\u00ebt e gjelbra, e b\u00ebjn\u00eb k\u00ebt\u00eb duke marr\u00eb energji nga rrezet e diellit. Ju mund t\u00eb mos mendoni se nj\u00eb person q\u00eb kullufit nj\u00eb biftek me l\u00ebng ngjan edhe aq me nj\u00eb pem\u00eb lisi me gjethe, por kur i sheh holl\u00eb ato, t\u00eb dy po marrin energji.<\/p>\n<p>Ky proces quhet metaboliz\u00ebm. S\u00eb pari, ju duhet t\u00eb merrni energji; thon\u00eb, nga kimikate t\u00eb pasura me energji si sheqerna. Pastaj duhet ta p\u00ebrdorni at\u00eb energji p\u00ebr t\u00eb nd\u00ebrtuar gj\u00ebra t\u00eb dobishme si qelizat.<\/p>\n<p>Ky proces i shfryt\u00ebzimit t\u00eb energjis\u00eb \u00ebsht\u00eb krejt\u00ebsisht thelb\u00ebsor, shum\u00eb studiues besojn\u00eb se duhet t\u00eb ket\u00eb qen\u00eb gj\u00ebja e par\u00eb, q\u00eb ka b\u00ebr\u00eb ndonj\u00ebher\u00eb jeta.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Uji vullkanik\" src=\"http:\/\/fjala.info\/2018\/p04dbljf.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Uji vullkanik \u00ebsht\u00eb i nxeht\u00eb dhe i pasur me kimikate<\/em><br \/>\n(Credit: Kseniya Ragozina\/Alamy)<\/p>\n<\/blockquote>\n<p>\u00c7far\u00eb mund t\u00eb duken k\u00ebto organizma t\u00eb vet\u00ebm t\u00eb metabolizmit? Nj\u00eb nga sugjerimet m\u00eb me ndikim <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0723202088800018?via%3Dihub\" target=\"_blank\" rel=\"noopener noreferrer\">u paraqit n\u00eb fund t\u00eb viteve 1980<\/a> nga <strong>G\u00fcnter W\u00e4chtersh\u00e4user<\/strong>. Ai nuk ishte nj\u00eb shkenc\u00ebtar me koh\u00eb t\u00eb plot\u00eb, por m\u00eb tep\u00ebr nj\u00eb avokat i patentave me nj\u00eb sfond n\u00eb kimis\u00eb.<\/p>\n<p>W\u00e4chtersh\u00e4user propozoi q\u00eb organizmat e par\u00eb ishin &#8220;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC373159\/\" target=\"_blank\" rel=\"noopener noreferrer\"><em>n\u00eb m\u00ebnyr\u00eb drastike t\u00eb ndryshme nga \u00e7do gj\u00eb q\u00eb dim\u00eb<\/em><\/a>&#8220;. Ata nuk ishin prej qelizave. Ata nuk kishin enzime, ADN ose ARN.<\/p>\n<blockquote><p><em>T\u00eb gjitha gj\u00ebrat e tjera q\u00eb p\u00ebrb\u00ebjn\u00eb organizma moderne &#8211; si ADN-ja, qelizat dhe truri &#8211; erdh\u00ebn m\u00eb von\u00eb<\/em><\/p><\/blockquote>\n<p>N\u00eb vend t\u00eb k\u00ebsaj, W\u00e4chtersh\u00e4user imagjinoi nj\u00eb rrjedh\u00eb t\u00eb ujit t\u00eb nxeht\u00eb q\u00eb rrjedh nga nj\u00eb vullkan. Uji ishte i pasur me gazra vullkanike si amoniaku dhe mbante gjurm\u00eb t\u00eb mineraleve nga zemra e vullkanit.<\/p>\n<p>Kur uji rridhte mbi shk\u00ebmb, filluan t\u00eb ndodhin reaksionet kimike. N\u00eb ve\u00e7anti, metalet nga uji ndihmuan komponimet e thjeshta organike p\u00ebr t&#8217;u shkrir\u00eb n\u00eb ato m\u00eb t\u00eb m\u00ebdha.<\/p>\n<p>Pika e kthes\u00ebs ishte krijimi i ciklit t\u00eb par\u00eb metabolik. Ky \u00ebsht\u00eb nj\u00eb proces, n\u00eb t\u00eb cilin nj\u00eb kimik konvertohet n\u00eb nj\u00eb s\u00ebr\u00eb kimikatesh t\u00eb tjer\u00eb, derisa p\u00ebrfundimisht t\u00eb rikrijohet kimikali origjinal. N\u00eb k\u00ebt\u00eb proces, i gjith\u00eb sistemi merr energji, q\u00eb mund t\u00eb p\u00ebrdoret p\u00ebr t\u00eb rifilluar ciklin &#8211; dhe p\u00ebr t\u00eb filluar t\u00eb b\u00ebjn\u00eb gj\u00ebra t\u00eb tjera.<\/p>\n<blockquote><p><em>Ciklet metabolike mund t\u00eb mos duken t\u00eb ngjashme me jet\u00ebn, por ato jan\u00eb themelore p\u00ebr jet\u00ebn<\/em><\/p><\/blockquote>\n<p>T\u00eb gjitha gj\u00ebrat e tjera q\u00eb p\u00ebrb\u00ebjn\u00eb organizma moderne &#8211; si ADN-ja, qelizat dhe truri &#8211; erdh\u00ebn m\u00eb von\u00eb, t\u00eb nd\u00ebrtuara n\u00eb an\u00ebn e pasme t\u00eb k\u00ebtyre cikleve kimike.<\/p>\n<p>K\u00ebto cikle metabolik\u00eb nuk ting\u00ebllojn\u00eb shum\u00eb si jet\u00eb. W\u00e4chtersh\u00e4user i quajti shpikjet e tij &#8220;organizma pararend\u00ebs&#8221; dhe shkroi se &#8220;mezi mund t\u00eb quhet se jetuan&#8221;.<\/p>\n<p>Por ciklet metabolike si ato t\u00eb p\u00ebrshkruara nga W\u00e4chtersh\u00e4user jan\u00eb thelbi i \u00e7do gj\u00ebje t\u00eb gjall\u00eb. Qelizat tuaja jan\u00eb n\u00eb thelb impiantet mikroskopike t\u00eb p\u00ebrpunimit kimik, duke kthyer nj\u00eb element kimik n\u00eb nj\u00eb tjet\u00ebr. Ciklet metabolike mund t\u00eb mos duken t\u00eb ngjashme me jet\u00ebn, por ato jan\u00eb themelore p\u00ebr jet\u00ebn.<\/p>\n<p>Gjat\u00eb viteve 1980 dhe 1990, W\u00e4chtersh\u00e4user p\u00ebrpunoi teorin\u00eb e tij n\u00eb detaje t\u00eb konsiderueshme. Ai p\u00ebrmendi cilat minerale jan\u00eb b\u00ebr\u00eb p\u00ebr sip\u00ebrfaqet m\u00eb t\u00eb mira dhe <a href=\"http:\/\/www.pnas.org\/lookup\/doi\/10.1073\/pnas.87.1.200\" target=\"_blank\" rel=\"noopener noreferrer\">cilat cikle kimike mund t\u00eb ndodhin<\/a>. Idet\u00eb e tij filluan t\u00eb t\u00ebrheqin p\u00ebrkrah\u00ebsit.<\/p>\n<p>Por gjith\u00e7ka ishte ende teorike. W\u00e4chtersh\u00e4user kishte nevoj\u00eb p\u00ebr nj\u00eb zbulim t\u00eb v\u00ebrtet\u00eb n\u00eb bot\u00eb, q\u00eb mb\u00ebshteste idet\u00eb e tij. P\u00ebr fat t\u00eb mir\u00eb, ajo tashm\u00eb ishte b\u00ebr\u00eb &#8211; nj\u00eb dekad\u00eb m\u00eb par\u00eb.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Shp\u00ebrthimet n\u00eb Paq\u00ebsor\" src=\"http:\/\/fjala.info\/2018\/p04cl34k.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Shp\u00ebrthimet n\u00eb Paq\u00ebsor<\/em><br \/>\n(Credit: Dr Bob Embley\/NOAA\/PMEL-NOAA Photo Library\/CC by 2.0)<\/p>\n<\/blockquote>\n<p>N\u00eb vitin 1977, nj\u00eb ekip i udh\u00ebhequr nga <strong>Jack Corliss<\/strong> i Oregon State University b\u00ebri nj\u00eb zhytje 1.5 milje (2.5 km) posht\u00eb n\u00eb Oqeanin Paq\u00ebsor lindor. Ata po v\u00ebzhgonin pik\u00ebn e nxeht\u00eb t\u00eb <em>Gal\u00e1pagos<\/em>, ku kreshtat e gjata t\u00eb shk\u00ebmbit ngriheshin nga dyshemeja e detit. Kreshtat, ata e dinin, ishin aktivisht vullkanike.<\/p>\n<blockquote><p><em>\u00c7do shp\u00ebrthim ishte nj\u00eb lloj shp\u00ebrndar\u00ebsi i sup\u00ebs primordiale<\/em><\/p><\/blockquote>\n<p>Corliss zbuloi se kreshtat ishin me vrima, n\u00eb thelb, burimet e ujit t\u00eb nxeht\u00eb. Uji i ngroht\u00eb, i pasur me kimikate po dilte nga posht\u00eb fundit t\u00eb detit dhe <a href=\"http:\/\/science.sciencemag.org\/content\/203\/4385\/1073\" target=\"_blank\" rel=\"noopener noreferrer\">derdhej p\u00ebrmes vrimave n\u00eb shk\u00ebmbinj<\/a>.<\/p>\n<p>\u00c7udit\u00ebrisht, k\u00ebto &#8220;shp\u00ebrthime hidrotermale&#8221; ishin t\u00eb populluara dendur nga kafsh\u00eb t\u00eb \u00e7uditshme. Kishte molusqe t\u00eb m\u00ebdha, limpets, midhje dhe krimba tub. Uji ishte gjithashtu i mbushur me baktere. T\u00eb gjitha k\u00ebto organizma jetonin me energji nga shfryrjet hidrotermale.<\/p>\n<p>Zbulimi i shp\u00ebrthimeve hidrotermale e b\u00ebri me em\u00ebr Corliss. Gjithashtu e b\u00ebri at\u00eb t\u00eb mendonte. N\u00eb vitin 1981, ai propozoi q\u00eb shfryrjet e ngjashme ekzistonin n\u00eb Tok\u00eb rreth kat\u00ebr miliard vjet m\u00eb par\u00eb dhe se <a href=\"http:\/\/archimer.ifremer.fr\/doc\/00245\/35661\/\" target=\"_blank\" rel=\"noopener noreferrer\">ato ishin vendi i origjin\u00ebs s\u00eb jet\u00ebs<\/a>. Ai do t\u00eb kalonte shum\u00eb nga pjesa e mbetur e karrier\u00ebs s\u00eb tij, duke punuar mbi k\u00ebt\u00eb ide.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Shp\u00ebrthimet n\u00eb Paq\u00ebsor\" src=\"http:\/\/fjala.info\/2018\/p04cl3fw.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Shp\u00ebrthimet hidroteknike mb\u00ebshtesin jet\u00ebn e \u00e7uditshme <\/em><br \/>\n(Credit: Dr Ken MacDonald\/Science Photo Library)<\/p>\n<\/blockquote>\n<p>Corliss propozoi q\u00eb shfryrjet (shp\u00ebrthimet) hidrotermale mund t\u00eb krijonin kokteje t\u00eb kimikateve. \u00c7do e \u00e7ar\u00eb, tha ai, ishte nj\u00eb lloj bombole me vrim\u00eb primordiale.<\/p>\n<blockquote><p><em>Komponimet kryesore si sheqernat &#8220;do t\u00eb mbijetonin &#8230; p\u00ebr sekonda m\u00eb s\u00eb shumti&#8221;<\/em><\/p><\/blockquote>\n<p>Nd\u00ebrsa uji i nxeht\u00eb shkonte deri n\u00ebp\u00ebr shk\u00ebmbinj, nxeht\u00ebsia dhe presioni shkaktuan komponimet e thjeshta organike p\u00ebr t&#8217;u shkrir\u00eb n\u00eb ato m\u00eb komplekse si aminoacidet, nukleotidet dhe sheqernat. Af\u00ebr kufirit me oqeanin, ku uji nuk ishte aq i nxeht\u00eb, ata filluan t\u00eb lidheshin nme zinxhir\u00eb &#8211; duke formuar karbohidratet, proteinat dhe nukleotidet si ADN-ja. Pastaj, kur uji u afrua n\u00eb oqean dhe u ftoh m\u00eb tej, k\u00ebto molekula u mblodh\u00ebn n\u00eb qeliza t\u00eb thjeshta.<\/p>\n<p>Ishte i zoti, dhe <a href=\"https:\/\/link.springer.com\/article\/10.1007%2FBF01808177\" target=\"_blank\" rel=\"noopener noreferrer\">kapi v\u00ebmendjen e njer\u00ebzve<\/a>. Por Stanley Miller, eksperimentet e s\u00eb cil\u00ebs kemi folur n\u00eb kapitullin e par\u00eb, nuk ishte i bindur. <a href=\"https:\/\/www.nature.com\/articles\/334609a0.epdf\" target=\"_blank\" rel=\"noopener noreferrer\">Duke shkruar n\u00eb vitin 1988<\/a>, ai argumentoi se shfryrjet ishin shum\u00eb t\u00eb nxehta.<\/p>\n<p>Nd\u00ebrsa nxeht\u00ebsia ekstreme do t\u00eb shkaktonte formimin e kimikateve si aminoacidet, eksperimentet e Millerit sugjeruan se do t&#8217;i shkat\u00ebrronin gjithashtu. Komponimet kryesore si sheqernat &#8220;do t\u00eb mbijetonin &#8230; p\u00ebr sekonda m\u00eb s\u00eb shumti&#8221;. P\u00ebr m\u00eb tep\u00ebr, k\u00ebto molekula t\u00eb thjeshta nuk do t\u00eb mund t\u00eb lidheshin n\u00eb zinxhir\u00eb, sepse uji p\u00ebrreth do t\u00eb thyente zinxhir\u00ebt pothuajse menj\u00ebher\u00eb.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Michael Russell\" src=\"http:\/\/fjala.info\/2018\/p04cl2cv.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Gjeologu dhe k\u00ebrkuesi mbi origjin\u00ebn e jet\u00ebs Michael Russell<\/em><br \/>\n(Credit: Nasa\/JPL\/CalTech)<\/p>\n<\/blockquote>\n<p>N\u00eb k\u00ebt\u00eb pik\u00eb, gjeologu <a href=\"https:\/\/science.jpl.nasa.gov\/people\/Russell\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Mike Russell<\/strong><\/a> hyri n\u00eb potere. Ai mendonte se teoria e shfryrjeve <a href=\"https:\/\/www.nature.com\/articles\/336117a0.epdf\" target=\"_blank\" rel=\"noopener noreferrer\">mund t\u00eb vihej n\u00eb pun\u00eb pas s\u00eb gjithave<\/a>. P\u00ebr m\u00eb tep\u00ebr, iu duk atij se shfryrjet ishin sht\u00ebpia ideale p\u00ebr organizmat pararend\u00ebs t\u00eb W\u00e4chtersh\u00e4user. Ky frym\u00ebzim do ta \u00e7onte at\u00eb t\u00eb krijonte nj\u00eb nga teorit\u00eb m\u00eb t\u00eb pranuara t\u00eb origjin\u00ebs s\u00eb jet\u00ebs.<\/p>\n<blockquote><p><em>N\u00ebse Russell ishte i sakt\u00eb, jeta filloi n\u00eb fund t\u00eb detit<\/em><\/p><\/blockquote>\n<p>Russell e kishte kaluar jet\u00ebn e tij t\u00eb hershme duke b\u00ebr\u00eb aspirina dhe duke b\u00ebr\u00eb k\u00ebrkime p\u00ebr minerale t\u00eb vlefshme dhe &#8211;<a href=\"https:\/\/www.nature.com\/news\/2009\/090520\/full\/459316a.html\" target=\"_blank\" rel=\"noopener noreferrer\"> n\u00eb nj\u00eb incident t\u00eb mrekulluesh\u00ebm n\u00eb vitet 1960<\/a> &#8211; duke koordinuar p\u00ebrgjigjen ndaj nj\u00eb shp\u00ebrthimi t\u00eb mundsh\u00ebm vullkanik, pavar\u00ebsisht se nuk kishte asnj\u00eb trajnim. Por interesi i tij i v\u00ebrtet\u00eb ishte se si sip\u00ebrfaqja e Tok\u00ebs ka ndryshuar gjat\u00eb epokave. Nga kjo perspektiv\u00eb gjeologjike, ka formuar <a href=\"https:\/\/aeon.co\/essays\/why-life-is-not-a-thing-but-a-restless-manner-of-being\" target=\"_blank\" rel=\"noopener noreferrer\">idet\u00eb e tij mbi origjin\u00ebn e jet\u00ebs<\/a>.<\/p>\n<p>N\u00eb vitet 1980, ai gjeti d\u00ebshmi fosile t\u00eb nj\u00eb lloji m\u00eb pak ekstrem t\u00eb shfryrjeve hidrotermale, ku temperaturat ishin n\u00ebn 150\u00b0C. K\u00ebto temperatura t\u00eb buta, argumentoi ai, do t\u00eb lejonin q\u00eb molekulat e jet\u00ebs t\u00eb mbijetonin shum\u00eb m\u00eb shum\u00eb se Milleri kishte supozuar se do t\u00eb b\u00ebnin.<\/p>\n<p>P\u00ebr m\u00eb tep\u00ebr, mbetjet fosile t\u00eb k\u00ebtyre shfryrjeve m\u00eb t\u00eb fresk\u00ebta mbanin di\u00e7ka t\u00eb \u00e7uditshme. Nj\u00eb mineral i quajtur pirit, i cili \u00ebsht\u00eb b\u00ebr\u00eb nga hekuri dhe squfuri, ishte formuar n\u00eb tuba rreth 1mm t\u00eb gjith\u00eb.<\/p>\n<p>N\u00eb laboratorin e tij, Russell zbuloi se <a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3121.1989.tb00364.x\/epdf\" target=\"_blank\" rel=\"noopener noreferrer\">piriti gjithashtu mund t\u00eb formonte blob\u00eb sferik\u00eb<\/a>. Ai sugjeroi q\u00eb molekulat e para komplekse organike jan\u00eb formuar brenda k\u00ebtyre strukturave t\u00eb thjeshta t\u00eb pirit.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Michael Russell\" src=\"http:\/\/fjala.info\/2018\/p04cl31d.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Nj\u00eb grumbull pirit hekuri<\/em> (Credit: James Petts, CC by 2.0)<\/p>\n<\/blockquote>\n<p>Rreth k\u00ebsaj kohe, W\u00e4chtersh\u00e4user kishte filluar t\u00eb botonte idet\u00eb e tij, t\u00eb cilat mb\u00ebshteteshin n\u00eb nj\u00eb rrym\u00eb me uj\u00eb kimik t\u00eb ngroht\u00eb, q\u00eb rrjedh mbi nj\u00eb mineral. Ai madje kishte propozuar, q\u00eb piriti ishte i p\u00ebrfshir\u00eb.<\/p>\n<blockquote><p><em>Ideja e tij mb\u00ebshtetej n\u00eb pun\u00ebn e nj\u00eb prej gjenive t\u00eb harruar t\u00eb shkenc\u00ebs moderne<\/em><\/p><\/blockquote>\n<p>Pra, <a href=\"https:\/\/link.springer.com\/article\/10.1007%2FBF00160147\" target=\"_blank\" rel=\"noopener noreferrer\">Russell i vendosi dy nga dy s\u00eb \u200b\u200bbashku<\/a>. Ai sugjeroi q\u00eb shfryrjet hidrotermale n\u00eb det t\u00eb thell\u00eb, t\u00eb mjaftueshme p\u00ebr t\u00eb formuar strukturat e piritit, prit\u00ebn organizmat paraardh\u00ebs t\u00eb W\u00e4chtersh\u00e4user. N\u00ebse Russell ishte i sakt\u00eb, jeta filloi n\u00eb fund t\u00eb detit &#8211; dhe metabolizmi u shfaq s\u00eb pari.<\/p>\n<p>Russell e vendosi gjith\u00eb k\u00ebt\u00eb n\u00eb nj\u00eb let\u00ebr t\u00eb botuar n\u00eb vitin 1993, 40 vjet pas eksperimentit klasik t\u00eb Miller. Ai nuk mori t\u00eb nj\u00ebjt\u00ebn mbulim t\u00eb ngaz\u00ebllyer mediatik, por ishte ndoshta m\u00eb i r\u00ebnd\u00ebsish\u00ebm. Russell kishte kombinuar dy ide n\u00eb dukje t\u00eb ndara &#8211; ciklet metabolike t\u00eb W\u00e4chtersh\u00e4user dhe shfryrjet hidrotermale t\u00eb Corliss-it &#8211; n\u00eb di\u00e7ka v\u00ebrtet bind\u00ebse.<\/p>\n<p>Vet\u00ebm p\u00ebr ta b\u00ebr\u00eb at\u00eb edhe m\u00eb mbres\u00ebl\u00ebn\u00ebse, Russell gjithashtu ofroi nj\u00eb shpjegim p\u00ebr m\u00ebnyr\u00ebn se si organizmat e par\u00eb e mor\u00ebn energjin\u00eb e tyre. Me fjal\u00eb t\u00eb tjera, ai zbuloi se si mund t\u00eb kishin punuar metabolizmi i tyre. Ideja e tij mb\u00ebshtetej n\u00eb pun\u00ebn e nj\u00eb prej gjenive t\u00eb harruar t\u00eb shkenc\u00ebs moderne.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Peter Mitchell\" src=\"http:\/\/fjala.info\/2018\/p04clbq6.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Peter Mitchell do t\u00eb fitonte nj\u00eb \u00c7mim Nob\u00ebl p\u00ebr hulumtimin e tij<\/em><br \/>\n(Credit: INTERFOTO\/Alamy)<\/p>\n<\/blockquote>\n<p>N\u00eb vitet 1960, biokimisti <a href=\"http:\/\/rsbm.royalsocietypublishing.org\/content\/roybiogmem\/40\/283\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Peter Mitchell<\/strong><\/a> u s\u00ebmur dhe u detyrua t\u00eb jap\u00eb dor\u00ebheqjen nga Universiteti i Edinburgut. N\u00eb vend t\u00eb k\u00ebsaj, ai krijoi nj\u00eb laborator privat n\u00eb nj\u00eb sht\u00ebpi t\u00eb vog\u00ebl n\u00eb Cornwall. I izoluar nga komuniteti shkencor, <a href=\"https:\/\/www.newscientist.com\/article\/mg20427306-200-was-our-oldest-ancestor-a-proton-powered-rock\/\" target=\"_blank\" rel=\"noopener noreferrer\">puna e tij u financua pjes\u00ebrisht nga nj\u00eb tuf\u00eb e lop\u00ebve t\u00eb qum\u00ebshtit<\/a>. Shum\u00eb biokimiste, duke p\u00ebrfshir\u00eb, <a href=\"https:\/\/www.nature.com\/articles\/46903.epdf\" target=\"_blank\" rel=\"noopener noreferrer\">fillimisht, Leslie Orgel<\/a>, puna e t\u00eb cil\u00ebve n\u00eb ARN q\u00eb ne diskutuam n\u00eb Kapitullin Dy, mendonin se idet\u00eb e tij ishin krejt\u00ebsisht qesharake.<\/p>\n<blockquote><p><em>Tani e dim\u00eb se procesi q\u00eb Mitchell identifikoi p\u00ebrdoret nga \u00e7do qenie e gjall\u00eb n\u00eb Tok\u00eb<\/em><\/p><\/blockquote>\n<p>M\u00eb pak se dy dekada m\u00eb von\u00eb, Mitchell arriti fitoren p\u00ebrfundimtare: <a href=\"https:\/\/www.nobelprize.org\/nobel_prizes\/chemistry\/laureates\/1978\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u00c7mimin Nobel t\u00eb 1978 n\u00eb Kimi<\/a>. Ai kurr\u00eb nuk ka qen\u00eb nj\u00eb em\u00ebr i familjes, por idet\u00eb e tij jan\u00eb n\u00eb \u00e7do tekst t\u00eb biologjis\u00eb.<\/p>\n<p>Mitchell kaloi karrier\u00ebn e tij duke zbuluar se \u00e7far\u00eb organizmash b\u00ebjn\u00eb me energjin\u00eb q\u00eb marrin nga ushqimi. N\u00eb fakt, ai po pyeste se si t\u00eb gjith\u00eb q\u00ebndrojm\u00eb t\u00eb gjall\u00eb nga momenti n\u00eb moment.<\/p>\n<p>Ai e dinte se t\u00eb gjitha qelizat ruanin energjin\u00eb e tyre n\u00eb t\u00eb nj\u00ebjt\u00ebn molekul\u00eb: <em>adenosine triphosphate<\/em> (ATP). Pak thelb\u00ebsore \u00ebsht\u00eb nj\u00eb zinxhir i tre fosfateve, t\u00eb lidhura me adenozin\u00eb. Shtimi i fosfatit t\u00eb tret\u00eb merr shum\u00eb energji, e cila m\u00eb pas mbyllet n\u00eb ATP.<\/p>\n<p>Kur nj\u00eb qeliz\u00eb ka nevoj\u00eb p\u00ebr energji &#8211; thon\u00eb, n\u00ebse nj\u00eb muskul duhet t\u00eb kontraktohet &#8211; thyen fosfatin e tret\u00eb nga nj\u00eb ATP. Kjo e kthen at\u00eb n\u00eb <em>adenosine difosfat<\/em> (ADP) dhe liron energjin\u00eb e ruajtur.<\/p>\n<blockquote><p><em>Ai kurr\u00eb nuk ka qen\u00eb nj\u00eb em\u00ebr i familjes<\/em><\/p><\/blockquote>\n<p>Mitchell donte t\u00eb dinte se si qelizat e b\u00ebnin ATP-n\u00eb n\u00eb radh\u00eb t\u00eb par\u00eb. Si e p\u00ebrqendronin ata energjin\u00eb e mjaftueshme n\u00eb nj\u00eb ADP, k\u00ebshtu q\u00eb fosfati i tret\u00eb do t\u00eb bashkohej?<\/p>\n<p>Mitchell e dinte q\u00eb enzima e b\u00ebn ATP t\u00eb ulet n\u00eb nj\u00eb membran\u00eb. Pra, ai sugjeroi q\u00eb qeliza pomponte grimca t\u00eb ngarkuara t\u00eb quajtura protone p\u00ebrgjat\u00eb membran\u00ebs, k\u00ebshtu q\u00eb kishte shum\u00eb protone n\u00eb nj\u00ebr\u00ebn an\u00eb dhe pothuajse asnj\u00eb nga ana tjet\u00ebr.<\/p>\n<p>Protonet do t\u00eb p\u00ebrpiqen t\u00eb rrjedhin prapa p\u00ebrmes membran\u00ebs p\u00ebr t\u00eb balancuar numrin e protoneve n\u00eb \u00e7do an\u00eb &#8211; por i vetmi vend ku mund t\u00eb kalonin ishte enzima. Rrjedha e protoneve q\u00eb kalonin p\u00ebrmes saj i dha enzim\u00ebs energjin\u00eb e nevojshme p\u00ebr t\u00eb b\u00ebr\u00eb ATP.<\/p>\n<p>Shihni se si qelizat e p\u00ebrdorin energjin\u00eb n\u00eb k\u00ebt\u00eb video:<br \/>\n(<em>videon shikojeni n\u00eb <a href=\"http:\/\/www.bbc.com\/earth\/story\/20161026-the-secret-of-how-life-on-earth-began\" target=\"_blank\" rel=\"noopener noreferrer\">shkrimin origjinal<\/a>, pasi nuk mund\u00ebm ta fusnim k\u00ebtu<\/em>)<\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/191144a0.epdf\" target=\"_blank\" rel=\"noopener noreferrer\">Mitchell e paraqiti p\u00ebr her\u00eb t\u00eb par\u00eb k\u00ebt\u00eb ide n\u00eb vitin 1961<\/a>. Ai kaloi 15 vitet e ardhshme <a href=\"https:\/\/www.nature.com\/articles\/213137a0.epdf\" target=\"_blank\" rel=\"noopener noreferrer\">duke e mbrojtur at\u00eb nga t\u00eb gjith\u00eb njer\u00ebzit<\/a>, derisa d\u00ebshmia u b\u00eb e pakund\u00ebrshtueshme. Tani e dim\u00eb se procesi q\u00eb Mitchell identifikoi p\u00ebrdoret nga \u00e7do qenie e gjall\u00eb n\u00eb Tok\u00eb. Tani po ndodh brenda qelizave tuaja. Ashtu si ADN-ja, ajo \u00ebsht\u00eb thelb\u00ebsore p\u00ebr jet\u00ebn ashtu si\u00e7 e njohim.<\/p>\n<blockquote><p><em>Shfryjet e Corliss nuk do t\u00eb b\u00ebnin<\/em><\/p><\/blockquote>\n<p>Pika ky\u00e7e q\u00eb mori Russell \u00ebsht\u00eb gradimi i protonit i Mitchellit: q\u00eb ka shum\u00eb protone n\u00eb nj\u00ebr\u00ebn an\u00eb t\u00eb nj\u00eb membrane dhe pak nga ana tjet\u00ebr. T\u00eb gjitha qelizat kan\u00eb nevoj\u00eb p\u00ebr nj\u00eb gradient proton, p\u00ebr t\u00eb ruajtur energjin\u00eb.<\/p>\n<p>Qelizat moderne i krijojn\u00eb gradient\u00ebt duke pompuar protonet n\u00ebp\u00ebr nj\u00eb membran\u00eb, por kjo p\u00ebrfshin\u00eb makineri komplekse molekulare, q\u00eb nuk mund t\u00eb hyjn\u00eb befas n\u00eb ekzistenc\u00eb. Pra, Russell b\u00ebri nj\u00eb hap m\u00eb t\u00eb logjiksh\u00ebm: <strong>jeta duhet t\u00eb ket\u00eb formuar diku me nj\u00eb gradient natyral t\u00eb protonit<\/strong>.<\/p>\n<p>Diku si nj\u00eb rrym\u00eb hidrotermale. Por kjo do t\u00eb duhej t\u00eb ishte nj\u00eb lloj i ve\u00e7ant\u00eb i ndarjes. Kur Toka ishte e re, detet ishin acid, dhe uji acid ka shum\u00eb protone q\u00eb fluturojn\u00eb brenda tij. P\u00ebr t\u00eb krijuar nj\u00eb gradient proton, uji duhet t\u00eb ket\u00eb qen\u00eb i ul\u00ebt n\u00eb proton: <a href=\"https:\/\/link.springer.com\/article\/10.1007%2FBF01582037\" target=\"_blank\" rel=\"noopener noreferrer\">duhet t\u00eb ket\u00eb qen\u00eb alkaline<\/a>.<\/p>\n<p>Shfryrjet e Corliss nuk do e b\u00ebnin. Jo vet\u00ebm q\u00eb ishin shum\u00eb t\u00eb nxehta, por ishin acide. Por n\u00eb vitin 2000, <a href=\"https:\/\/www.ocean.washington.edu\/home\/Deborah+Kelley\" target=\"_blank\" rel=\"noopener noreferrer\">Deborah Kelley<\/a> nga Universiteti i Uashingtonit zbuloi shfryrjen e par\u00eb alkaline.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Terren hidrotermal n\u00eb Lost City\" src=\"http:\/\/fjala.info\/2018\/p04cl45r.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Pjes\u00eb e terrenit hidrotermal n\u00eb &#8220;Lost City&#8221; n\u00eb Atlantik<\/em><br \/>\n(Credit: 916 Collection\/Alamy)<\/p>\n<\/blockquote>\n<p>Kelley kishte p\u00ebr t\u00eb luftuar vet\u00ebm p\u00ebr t&#8217;u b\u00ebr\u00eb shkenc\u00ebtare n\u00eb radh\u00eb t\u00eb par\u00eb. Babai i saj vdiq nd\u00ebrsa ajo po mbaronte shkoll\u00ebn e mesme, dhe <a href=\"http:\/\/oceanexplorer.noaa.gov\/edu\/oceanage\/05kelley\/welcome.html\" target=\"_blank\" rel=\"noopener noreferrer\">ajo u detyrua t\u00eb punonte or\u00eb t\u00eb gjata<\/a> p\u00ebr t\u00eb mb\u00ebshtetur veten gjat\u00eb kolegjit.<\/p>\n<blockquote><p><em>Ai u bind se shfryrjet si ato t\u00eb Qytetit t\u00eb Humbur (Lost City) ishin ato, ku filloi jeta<\/em><\/p><\/blockquote>\n<p>Por ajo arriti, dhe u befasua si nga vullkanet n\u00ebnujore dhe nga shfryrjet e nxehta hidrotermale. Kjo dashuri binjake p\u00ebrfundimisht e \u00e7uan at\u00eb n\u00eb mes t\u00eb Oqeanit Atlantik. Atje, <a href=\"http:\/\/www.bbc.com\/earth\/bespoke\/story\/the-cracks-ripping-earth-apart\/index.html\" target=\"_blank\" rel=\"noopener noreferrer\">korja e Tok\u00ebs \u00ebsht\u00eb duke u larguar<\/a> dhe nj\u00eb kresht\u00eb e maleve ngrihet nga fundi i detit.<\/p>\n<p>N\u00eb k\u00ebt\u00eb kresht\u00eb, Kelley gjeti <a href=\"https:\/\/www.ocean.washington.edu\/home\/Deborah+Kelley\" target=\"_blank\" rel=\"noopener noreferrer\">nj\u00eb fush\u00eb t\u00eb shfryrjeve hidrotermale<\/a>, q\u00eb ajo e quajti &#8220;Lost City&#8221;. Ato nuk jan\u00eb si ato q\u00eb kishte gjetur Corliss. Uji q\u00eb rrjedh prej tyre \u00ebsht\u00eb vet\u00ebm 40-75\u00b0C, dhe but\u00ebsisht alkalik. Mineralet e karbonateve nga ky uj\u00eb jan\u00eb grumbulluar n\u00eb &#8220;oxhaqe&#8221; t\u00eb bardha q\u00eb ngrihen nga shtrati i detit si tubat e organeve. Pamja e tyre \u00ebsht\u00eb e frikshme dhe e ngjashme me fantazmat, por kjo \u00ebsht\u00eb mashtruese: ata jan\u00eb sht\u00ebpia e komuniteteve t\u00eb dendura t\u00eb mikroorganizmave, q\u00eb lul\u00ebzojn\u00eb n\u00eb uj\u00eb t\u00eb ndezur.<\/p>\n<p>K\u00ebto shina alkaline ishin p\u00ebrshtatje e p\u00ebrkryer p\u00ebr idet\u00eb e Russellit. Ai u bind se shfryrjet si ato t\u00eb Qytetit t\u00eb Humbur ishin aty ku filloi jeta.<\/p>\n<p>Por ai kishte nj\u00eb problem. Duke qen\u00eb nj\u00eb gjeolog, ai nuk dinte mjaftuesh\u00ebm p\u00ebr qelizat biologjike p\u00ebr ta b\u00ebr\u00eb teorin\u00eb e tij t\u00eb v\u00ebrtet\u00eb bind\u00ebse.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Terren hidrotermal n\u00eb Lost City\" src=\"http:\/\/fjala.info\/2018\/p04cl3y4.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Shfryrja hidrotermale &#8220;Tymuesi i zi&#8221; <\/em><br \/>\n(Credit: NOAA PMEL Vents Program\/Science Photo Library)<\/p>\n<\/blockquote>\n<p>Pra, Russell u bashkua me biologun <a href=\"http:\/\/www.molevol.hhu.de\/en\/prof-dr-w-f-martin.html\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>William Martin<\/strong><\/a>, nj\u00eb amerikan i pand\u00ebrgjegjsh\u00ebm q\u00eb ka kaluar shumic\u00ebn e karrier\u00ebs s\u00eb tij n\u00eb Gjermani. N\u00eb vitin 2003, pal\u00ebt paraqit\u00ebn nj\u00eb <a href=\"http:\/\/rstb.royalsocietypublishing.org\/content\/358\/1429\/59\" target=\"_blank\" rel=\"noopener noreferrer\">version t\u00eb p\u00ebrmir\u00ebsuar t\u00eb ideve t\u00eb m\u00ebparshme t\u00eb Russell<\/a>. \u00cbsht\u00eb ndoshta historia m\u00eb e detajuar e asaj se si filloi jeta.<\/p>\n<blockquote><p><em>Kjo histori konsiderohet tani si nj\u00eb nga hipotezat kryesore p\u00ebr origjin\u00ebn e jet\u00ebs<\/em><\/p><\/blockquote>\n<p>N\u00eb saj\u00eb t\u00eb Kelley, ata tani e dinin se shk\u00ebmbinjt\u00eb e shfryjnajave alkaline ishin poroze: ata u b\u00ebn\u00eb me vrima t\u00eb vogla t\u00eb mbushura me uj\u00eb. K\u00ebto xhepa t\u00eb vegj\u00ebl, sugjeruan ata, vepruan si &#8220;qeliza&#8221;. Secili xhep p\u00ebrmban kimikate esenciale, duke p\u00ebrfshir\u00eb mineralet si piritit. Kombinuar me gradientin natyror t\u00eb protonit nga dalja, ata ishin vendi ideal q\u00eb t\u00eb fillonte metabolizmi.<\/p>\n<p>Sapo jeta kishte shfryt\u00ebzuar energjin\u00eb kimike t\u00eb ujit t\u00eb ndezur, Russell dhe Martin thon\u00eb, ajo filloi t\u00eb b\u00ebnte molekula si ARN. P\u00ebrfundimisht ajo krijoi membran\u00ebn e vet dhe u b\u00eb nj\u00eb qeliz\u00eb e v\u00ebrtet\u00eb dhe u arratis nga shk\u00ebmbi poroz n\u00eb uj\u00eb t\u00eb hapur.<\/p>\n<p><strong>Kjo histori konsiderohet tani si nj\u00eb nga hipotezat kryesore p\u00ebr origjin\u00ebn e jet\u00ebs.<\/strong><\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Qelizat q\u00eb ikin nga shfryrjet hidrotermale\" src=\"http:\/\/fjala.info\/2018\/p04clc5r.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Qelizat q\u00eb ikin nga shfryrjet hidrotermale<\/em><br \/>\n(Credit: Richard Bizley\/Science Photo Library)<\/p>\n<\/blockquote>\n<p>Ai gjeti mb\u00ebshtetje t\u00eb fuqishme n\u00eb korrik 2016, kur Martin botoi nj\u00eb studim q\u00eb rind\u00ebrtonte disa nga tiparet e &#8220;paraardh\u00ebsit t\u00eb fundit universal t\u00eb p\u00ebrbashk\u00ebt&#8221; (LUCA). Ky \u00ebsht\u00eb organizmi q\u00eb jetonte miliarda vite m\u00eb par\u00eb dhe nga i cili zbriti gjith\u00eb jeta ekzistuese.<\/p>\n<blockquote><p><em>P\u00ebrkrah\u00ebsit e ARN Bot\u00ebrore thon\u00eb se teoria e ftohjes ka dy probleme<\/em><\/p><\/blockquote>\n<p>Ne ndoshta nuk do t\u00eb gjejm\u00eb kurr\u00eb prova t\u00eb drejtp\u00ebrdrejta fosile t\u00eb LUCA-s, por ne ende mund t\u00eb b\u00ebjm\u00eb nj\u00eb supozim t\u00eb arsimuar se si mund t\u00eb duket dhe t\u00eb sillemi duke shikuar mikroorganizmat q\u00eb mbijetojn\u00eb sot. Kjo \u00ebsht\u00eb ajo q\u00eb b\u00ebri Martin.<\/p>\n<p>Ai shqyrtoi ADN-n\u00eb e 1,930 mikroorganizmave moderne dhe identifikoi 355 gjene, q\u00eb pothuajse t\u00eb gjith\u00eb i kishin. Kjo \u00ebsht\u00eb padyshim d\u00ebshmi se k\u00ebto 355 gjene jan\u00eb trash\u00ebguar, nga brezi n\u00eb brez, q\u00eb kur ato 1930 mikroba kan\u00eb nj\u00eb paraardh\u00ebs t\u00eb p\u00ebrbashk\u00ebt &#8211; af\u00ebrsisht n\u00eb koh\u00ebn kur LUCA ishte gjall\u00eb.<\/p>\n<p>355 gjenet p\u00ebrfshinin disa p\u00ebr shfryt\u00ebzimin e nj\u00eb gradienti proton, por jo gjenet p\u00ebr gjenerimin e nj\u00eb tjet\u00ebr &#8211; pik\u00ebrisht si\u00e7 do t\u00eb parashikonin teorit\u00eb e Russell dhe Martin. P\u00ebr m\u00eb tep\u00ebr, LUCA duket se \u00ebsht\u00eb p\u00ebrshtatur me pranin\u00eb e kimikateve si metani, gj\u00eb q\u00eb sugjeron se ajo ka banuar n\u00eb nj\u00eb mjedis vullkanik &#8211; si nj\u00eb \u00e7arje.<\/p>\n<p>Pavar\u00ebsisht nga kjo, mb\u00ebshtet\u00ebsit e ARN Bot\u00ebrore thon\u00eb se teoria e ftohjes ka dy probleme. Dikush mund t\u00eb jet\u00eb i fiksuar: tjetra mund t\u00eb jet\u00eb fatale.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Shfryrjet hidrotermale - sht\u00ebpit\u00eb e organizmave t\u00eb \u00e7uditsh\u00ebm\" src=\"http:\/\/fjala.info\/2018\/p04cl2q9.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Shfryrjet hidrotermale jan\u00eb sht\u00ebpit\u00eb e organizmave t\u00eb \u00e7uditsh\u00ebm<br \/>\nsi k\u00ebto gaforre anomurane<\/em><br \/>\n(Credit: A. D. Rogers et al, PLoS Biology, CC by 2.5)<\/p>\n<\/blockquote>\n<p>Problemi i par\u00eb \u00ebsht\u00eb se nuk ka d\u00ebshmi eksperimentale p\u00ebr proceset q\u00eb p\u00ebrshkruajn\u00eb Russell dhe Martin. Ata kan\u00eb nj\u00eb histori hap pas hapi, por asnj\u00eb nga hapat nuk jan\u00eb par\u00eb n\u00eb nj\u00eb laborator.<\/p>\n<p>&#8220;<em>Njer\u00ebzit t\u00eb cil\u00ebt mendojn\u00eb se replikimi ishte i pari, ato vazhdimisht japin t\u00eb dh\u00ebna t\u00eb reja eksperimentale<\/em>&#8220;, thot\u00eb eksperti i origjin\u00ebs s\u00eb jet\u00ebs Armen Mulkidjanian. &#8220;<em>Njer\u00ebzit q\u00eb favorizojn\u00eb metabolizmin &#8211; s\u00eb pari nuk e b\u00ebjn\u00eb k\u00ebt\u00eb<\/em>&#8220;.<\/p>\n<blockquote><p><em>Kimia e t\u00eb gjitha k\u00ebtyre molekulave \u00ebsht\u00eb i papajtueshme me ujin<\/em><\/p><\/blockquote>\n<p>Kjo mund t\u00eb ndryshoj\u00eb, fal\u00eb kolegut Martinit, <a href=\"http:\/\/nick-lane.net\/\" target=\"_blank\" rel=\"noopener noreferrer\">Nick Lane<\/a> t\u00eb University College London. Ai ka nd\u00ebrtuar nj\u00eb &#8220;<a href=\"https:\/\/link.springer.com\/article\/10.1007%2Fs00239-014-9658-4\" target=\"_blank\" rel=\"noopener noreferrer\">origjin\u00eb t\u00eb reaktorit t\u00eb jet\u00ebs<\/a>&#8220;, i cili do t\u00eb simuloj\u00eb kushtet brenda nj\u00eb tret\u00ebsire alkaline. Ai shpreson t\u00eb v\u00ebzhgoj\u00eb cikle metabolike, dhe ndoshta edhe molekula si ARN. Por \u00ebsht\u00eb n\u00eb fillimet e tij.<\/p>\n<p>Problemi i dyt\u00eb \u00ebsht\u00eb vendndodhja e avujve n\u00eb det t\u00eb thell\u00eb. Si Miller vuri n\u00eb dukje n\u00eb 1988, molekulat e gjata t\u00eb zinxhirit si ARN dhe proteinat nuk mund t\u00eb formohen n\u00eb uj\u00eb pa enzima p\u00ebr t&#8217;i ndihmuar ata.<\/p>\n<p>P\u00ebr shum\u00eb studiues, ky \u00ebsht\u00eb nj\u00eb argument i hedhur posht\u00eb. &#8220;<em>N\u00ebse keni nj\u00eb formim n\u00eb kimi, ju nuk mund ta pranoni iden\u00eb e shfryrjeve t\u00eb detit t\u00eb thell\u00eb, sepse e dini se kimia e t\u00eb gjitha k\u00ebtyre molekulave \u00ebsht\u00eb e pap\u00ebrputhshme me ujin<\/em>&#8220;, thot\u00eb Mulkidjanian.<\/p>\n<p>Pavar\u00ebsisht k\u00ebsaj, Russell dhe aleat\u00ebt e tij mbeten esencial\u00eb.<\/p>\n<p>Por n\u00eb dekad\u00ebn e fundit, nj\u00eb qasje e tret\u00eb ka dal\u00eb n\u00eb pah, e mb\u00ebshtetur nga nj\u00eb seri eksperimentesh t\u00eb jasht\u00ebzakonshme. Kjo premton di\u00e7ka q\u00eb as ARN bot\u00ebrore, as shfryrjet hidrotermale nuk kan\u00eb arritur deri tani: <em>nj\u00eb m\u00ebnyr\u00eb p\u00ebr t\u00eb b\u00ebr\u00eb nj\u00eb qeliz\u00eb t\u00eb t\u00ebr\u00eb nga e para<\/em>.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Nuk ka jet\u00eb pa qelizat\" src=\"http:\/\/fjala.info\/2018\/p04cl3qr.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Ndoshta nuk mund t\u00eb ket\u00eb jet\u00eb pa qelizat<\/em><br \/>\n(Credit: Equinox Graphics Ltd)<\/p>\n<\/blockquote>\n<p><strong>Kapitulli 5. Si t\u00eb krijohet nj\u00eb qeliz\u00eb<\/strong><\/p>\n<p><em>Deri n\u00eb fillim t\u00eb viteve 2000, kishte dy ide kryesore rreth asaj se si mund t\u00eb kishte filluar jeta. Mb\u00ebshtet\u00ebsit e &#8220;RNA World&#8221; ishin t\u00eb bindur se jeta filloi me nj\u00eb molekul\u00eb t\u00eb vet\u00eb-p\u00ebrs\u00ebritur. Nd\u00ebrkoh\u00eb, shkenc\u00ebtar\u00ebt n\u00eb kampin &#8220;metabolizmi &#8211; i pari&#8221; kishin zhvilluar nj\u00eb p\u00ebrshkrim t\u00eb holl\u00ebsish\u00ebm rreth asaj, se si jeta mund t\u00eb kishte filluar n\u00eb shfryrjet hidrotermale n\u00eb det t\u00eb thell\u00eb. Megjithat\u00eb, nj\u00eb ide e tret\u00eb ishte gati p\u00ebr t\u00eb dal\u00eb n\u00eb drit\u00eb.<\/em><\/p>\n<p>\u00c7do gj\u00eb e gjall\u00eb n\u00eb Tok\u00eb \u00ebsht\u00eb b\u00ebr\u00eb nga qelizat. \u00c7do qeliz\u00eb \u00ebsht\u00eb n\u00eb thelb nj\u00eb top i l\u00ebng\u00ebt, \u200b\u200bme nj\u00eb mur mbrojt\u00ebs t\u00eb jasht\u00ebm ose &#8220;membran\u00eb&#8221;.<\/p>\n<p>Q\u00ebllimi i nj\u00eb qelize \u00ebsht\u00eb q\u00eb t&#8217;i mbaj\u00eb <a href=\"https:\/\/wsimag.com\/science-and-technology\/20118-why-is-life-cellular\" target=\"_blank\" rel=\"noopener noreferrer\">t\u00eb gjitha gj\u00ebrat thelb\u00ebsore t\u00eb jet\u00ebs s\u00eb bashku<\/a>. N\u00ebse muri i jasht\u00ebm do t\u00eb shqyhet, p\u00ebrmbjtja do t\u00eb dal\u00eb dhe qeliza vdes &#8211; ashtu si nj\u00eb person, i cili \u00ebsht\u00eb zb\u00ebrthyer, n\u00eb p\u00ebrgjith\u00ebsi nuk ka koh\u00eb p\u00ebr t\u00eb jetuar.<\/p>\n<blockquote><p><em>N\u00eb nxeht\u00ebsin\u00eb dhe stuhin\u00eb e Tok\u00ebs s\u00eb hershme, disa l\u00ebnd\u00eb t\u00eb para duhet t\u00eb jen\u00eb mbledhur n\u00eb qeliza t\u00eb pap\u00ebrpunuara<\/em><\/p><\/blockquote>\n<p>Muri i jasht\u00ebm i qeliz\u00ebs \u00ebsht\u00eb aq thelb\u00ebsor, disa studiues t\u00eb origjin\u00ebs s\u00eb jet\u00ebs argumentojn\u00eb se duhet t\u00eb ket\u00eb qen\u00eb gj\u00ebja e par\u00eb q\u00eb u shfaq. Ata mendojn\u00eb se p\u00ebrpjekjet e &#8220;gjenetik\u00ebs s\u00eb par\u00eb&#8221; t\u00eb diskutuara n\u00eb kapitullin e tret\u00eb dhe idet\u00eb e &#8220;metabolizmit t\u00eb par\u00eb&#8221; t\u00eb diskutuara n\u00eb kapitullin e kat\u00ebrt, jan\u00eb t\u00eb gabuara. Alternativa e tyre &#8211; &#8220;<em>compartmentalisation-first<\/em>&#8221; (kompartmentalizimi &#8211; s\u00eb pari) &#8211; ka kampion in e vet <a href=\"http:\/\/www.plluisi.org\/\" target=\"_blank\" rel=\"noopener noreferrer\">Pier Luigi Luisi<\/a> n\u00eb Universitetin Roma Tre n\u00eb Rom\u00eb t\u00eb Italis\u00eb.<\/p>\n<p>Arsyetimi i Luisit \u00ebsht\u00eb i thjesht\u00eb dhe i v\u00ebshtir\u00eb p\u00ebr t&#8217;u debatuar. Si mund t\u00eb krijoni nj\u00eb metaboliz\u00ebm pune ose nj\u00eb ARN t\u00eb vet\u00eb-p\u00ebrs\u00ebritur, secila prej t\u00eb cilave mb\u00ebshtetet n\u00eb nj\u00eb shum\u00eb t\u00eb kimikateve n\u00eb nj\u00eb vend, n\u00ebse nuk keni nj\u00eb en\u00eb p\u00ebr t\u00eb mbajtur t\u00eb gjitha molekulat?<\/p>\n<p>N\u00ebse e pranoni k\u00ebt\u00eb, ka vet\u00ebm nj\u00eb m\u00ebnyr\u00eb q\u00eb jeta t\u00eb ket\u00eb filluar. Disi, n\u00eb nxeht\u00ebsin\u00eb dhe stuhin\u00eb e Tok\u00ebs s\u00eb hershme, disa l\u00ebnd\u00eb t\u00eb para duhet t\u00eb jen\u00eb mbledhur n\u00eb qeliza t\u00eb pap\u00ebrpunuara, ose &#8220;<em>protocells<\/em>&#8221; (paraqeliza). Sfida \u00ebsht\u00eb q\u00eb kjo t\u00eb ndodh\u00eb n\u00eb nj\u00eb laborator: p\u00ebr t\u00eb krijuar nj\u00eb qeliz\u00eb t\u00eb thjesht\u00eb t\u00eb gjall\u00eb.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Gjallesat p\u00ebrb\u00ebhen nga qelizat\" src=\"http:\/\/fjala.info\/2018\/p04cl2p6.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>T\u00eb gjitha gjallesat jan\u00eb t\u00eb p\u00ebrb\u00ebra nga qelizat<\/em><br \/>\n(Credit: Cultura Creative RF\/Alamy)<\/p>\n<\/blockquote>\n<p>Luisi mund t\u00eb gjurmoj\u00eb idet\u00eb e tij gjat\u00eb gjith\u00eb rrug\u00ebs p\u00ebr te Alexander Oparin dhe n\u00eb agimin e origjin\u00ebs s\u00eb shkenc\u00ebs n\u00eb BRSS &#8211; t\u00eb diskutuara n\u00eb Kapitullin e par\u00eb. Oparin theksoi faktin q\u00eb kimikate t\u00eb caktuara formohen n\u00eb blloqe t\u00eb quajtura <em>koacervate<\/em>, t\u00eb cilat mund t\u00eb mbajn\u00eb substanca t\u00eb tjera n\u00eb b\u00ebrthamat e tyre. Ai sugjeroi se k\u00ebto <em>koacervate <\/em>ishin protocellet (paraqelizat) e para.<\/p>\n<blockquote><p><em>Sfida ishte p\u00ebr t\u00eb b\u00ebr\u00eb protocells nga vet\u00ebm sendet e duhura<\/em><\/p><\/blockquote>\n<p>\u00c7do substanc\u00eb yndyrore ose me vaj do t\u00eb formoj\u00eb blobe ose filma n\u00eb uj\u00eb. K\u00ebto kimikate njihen kolektivisht si lipide, dhe ideja q\u00eb ata formuan jet\u00ebn e par\u00eb \u00ebsht\u00eb quajtur &#8220;<a href=\"https:\/\/link.springer.com\/article\/10.1023%2FA%3A1006746807104\" target=\"_blank\" rel=\"noopener noreferrer\">Bota lipide<\/a>&#8220;.<\/p>\n<p>Por vet\u00ebm formimi i blobeve nuk mjafton. Blobet duhet t\u00eb jen\u00eb t\u00eb q\u00ebndrueshme, ata duhet t\u00eb jen\u00eb n\u00eb gjendje t\u00eb ndahen p\u00ebr t\u00eb formuar blobet vajza dhe ata kan\u00eb nevoj\u00eb t\u00eb pakt\u00ebn ta kontrollojn\u00eb at\u00eb q\u00eb l\u00ebviz brenda dhe jasht\u00eb tyre &#8211; t\u00eb gjitha k\u00ebto pa proteinat e p\u00ebrpunuara q\u00eb p\u00ebrdorin qelizat moderne, p\u00ebr t&#8217;i arritur k\u00ebto gj\u00ebra.<\/p>\n<p>Sfida ishte p\u00ebr t\u00eb b\u00ebr\u00eb protocells (paraqeliza) nga vet\u00ebm sendet e duhura. Megjith\u00eb p\u00ebrpjekjen e shum\u00eb substancave gjat\u00eb dekadave, Luisi kurr\u00eb nuk ka b\u00ebr\u00eb asgj\u00eb aq t\u00eb gjall\u00eb, sa t\u00eb jet\u00eb bind\u00ebse.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Qelizat u krijuan disi\" src=\"http:\/\/fjala.info\/2018\/p04cl321.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Qelizat u krijuan disi<\/em><br \/>\n(Credit: Christian Jegou\/Publiphoto Diffusion\/Science Photo Library)<\/p>\n<\/blockquote>\n<p>Pastaj n\u00eb vitin 1994, Luisi b\u00ebri nj\u00eb sugjerim t\u00eb guximsh\u00ebm. Ai propozoi q\u00eb <a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bbpc.19940980918\/pdf\" target=\"_blank\" rel=\"noopener noreferrer\">protocells (para-qelizat) e para duhet t\u00eb ken\u00eb RNA t\u00eb p\u00ebrfshira<\/a>. P\u00ebr m\u00eb tep\u00ebr, kjo ARN duhet t\u00eb ket\u00eb qen\u00eb n\u00eb gjendje t\u00eb p\u00ebrs\u00ebritet brenda protocells (para-qelizave).<\/p>\n<blockquote><p><em>Ne do t\u00eb takohemi n\u00eb mbledhjet e origjin\u00ebs dhe do t\u00eb hyjm\u00eb n\u00eb k\u00ebto argumente t\u00eb gjata<\/em><\/p><\/blockquote>\n<p>Ishte nj\u00eb k\u00ebrkes\u00eb e madhe dhe kjo n\u00ebnkuptonte braktisjen e ndarjes s\u00eb past\u00ebr &#8211; qasja e par\u00eb. Por Luisi kishte arsye t\u00eb mira.<\/p>\n<p>Nj\u00eb qeliz\u00eb me nj\u00eb mur t\u00eb jasht\u00ebm, por pa gjene brenda tij, nuk mund t\u00eb b\u00ebnte shum\u00eb gj\u00ebra. Mund t\u00eb jet\u00eb n\u00eb gjendje t\u00eb ndahet n\u00eb qelizat vajza, por nuk mund t\u00eb kaloj\u00eb ndonj\u00eb informacion rreth vetes tek pasardh\u00ebsit e saj. Mund t\u00eb filloj\u00eb t\u00eb zhvillohet dhe t\u00eb b\u00ebhet m\u00eb komplekse, n\u00ebse p\u00ebrmban disa gjene.<\/p>\n<p>Kjo ide s\u00eb shpejti do t\u00eb fitonte nj\u00eb p\u00ebrkrah\u00ebs thelb\u00ebsor n\u00eb <strong>Jack Szostak<\/strong>, puna e t\u00eb cilit n\u00eb Hipotez\u00ebn Bot\u00ebrore t\u00eb ARN-s\u00eb, q\u00eb kemi eksploruar n\u00eb Kapitullin Tre. Nd\u00ebrsa Luisi ishte nj\u00eb an\u00ebtar i kampit t\u00eb kompartmentalizimit &#8211; i pari, Szostak mb\u00ebshteti gjenetik\u00ebn &#8211; e para, k\u00ebshtu, q\u00eb p\u00ebr shum\u00eb vite ata nuk u pan\u00eb sy-m\u00eb-sy.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Pothuajse e gjith\u00eb jeta \u00ebsht\u00eb me qeliza t\u00eb vetme\" src=\"http:\/\/fjala.info\/2018\/p04cl3lv.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Pothuajse e gjith\u00eb jeta \u00ebsht\u00eb me qeliza t\u00eb vetme<\/em><br \/>\n(Credit: Science Photo Library\/Alamy)<\/p>\n<\/blockquote>\n<p>&#8220;<em>Ne do t\u00eb takohemi n\u00eb mbledhjet e origjin\u00ebs dhe do t\u00eb hyjm\u00eb n\u00eb k\u00ebto argumente t\u00eb gjata, rreth asaj se kush ishte m\u00eb e r\u00ebnd\u00ebsishme dhe kush erdhi m\u00eb par\u00eb<\/em>&#8220;, kujton Szostak. &#8220;<em>P\u00ebrfundimisht, ne kuptuam se qelizat i kan\u00eb t\u00eb dyja. Ne arrit\u00ebm n\u00eb nj\u00eb konsensus se p\u00ebr origjin\u00ebn e jet\u00ebs, ishte kritike q\u00eb t\u00eb kemi edhe ndarje edhe nj\u00eb sistem gjenetik<\/em>&#8220;.<\/p>\n<blockquote><p><em>Szostak dhe dy koleg\u00eb shpall\u00ebn nj\u00eb sukses t\u00eb madh<\/em><\/p><\/blockquote>\n<p>N\u00eb 2001, <a href=\"https:\/\/www.nature.com\/articles\/35053176\" target=\"_blank\" rel=\"noopener noreferrer\">Szostak dhe Luisi e vendos\u00ebn rastin e tyre p\u00ebr k\u00ebt\u00eb qasje m\u00eb t\u00eb unifikuar<\/a>. Duke shkruar n\u00eb Nature, ata argumentuan se duhet t\u00eb jet\u00eb e mundur t\u00eb krijohen qeliza t\u00eb thjeshta t\u00eb gjalla nga e para, duke pritur ARN t\u00eb p\u00ebrs\u00ebritura n\u00eb nj\u00eb blob t\u00eb thjesht\u00eb dhe t\u00eb yndyrsh\u00ebm.<\/p>\n<p>Ishte nj\u00eb ide dramatike, dhe Szostak shpejt vendosi t\u00eb vinte parat\u00eb e tij aty ku ishte goja e tij. Me arsyetimin se &#8220;<em>ne nuk mund ta heqim k\u00ebt\u00eb teori pa e mb\u00ebshtetur at\u00eb<\/em>&#8220;, ai vendosi t\u00eb filloj\u00eb t\u00eb eksperimentoj\u00eb me protocells (para-qelizat).<\/p>\n<p>Dy vjet m\u00eb von\u00eb, Szostak dhe dy koleg\u00eb shpall\u00ebn nj\u00eb sukses t\u00eb madh.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Vesicles jan\u00eb kontejner\u00eb t\u00eb thjesht\u00eb lipidesh\" src=\"http:\/\/fjala.info\/2018\/p04cl3dg.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Vesicles jan\u00eb kontejner\u00eb t\u00eb thjesht\u00eb t\u00eb b\u00ebr\u00eb nga lipidet<\/em><br \/>\n(Credit: Alfred Pasieka\/Science Photo Library)<\/p>\n<\/blockquote>\n<p>Ata kishin eksperimentuar me fshik\u00ebzat: blobet sferike, me dy shtresa t\u00eb acideve yndyrore n\u00eb pjes\u00ebn e jashtme dhe nj\u00eb b\u00ebrtham\u00eb qendrore t\u00eb l\u00ebngshme.<\/p>\n<blockquote><p><em>Montmorillonitet dhe argjila si ajo, mund t\u00eb jen\u00eb t\u00eb r\u00ebnd\u00ebsishme n\u00eb origjin\u00ebn e jet\u00ebs<\/em><\/p><\/blockquote>\n<p>Duke u p\u00ebrpjekur p\u00ebr t\u00eb gjetur nj\u00eb m\u00ebnyr\u00eb p\u00ebr t\u00eb p\u00ebrshpejtuar krijimin e vezikulave, ata shtuan grimca t\u00eb vogla t\u00eb nj\u00eb lloj balta t\u00eb quajtur montmorillonite.<\/p>\n<p>Kjo e b\u00ebri vezikul\u00ebn 100 her\u00eb m\u00eb t\u00eb shpejt\u00eb. Sip\u00ebrfaqja e argjil\u00ebs veproi si nj\u00eb katalizator, ashtu si nj\u00eb enzim\u00eb.<\/p>\n<p>P\u00ebr m\u00eb tep\u00ebr, vezikulat mund t\u00eb thithin grimcat e montmorillonit dhe fillesat e ARN-s\u00eb nga sip\u00ebrfaqja e balt\u00ebs. <a href=\"http:\/\/science.sciencemag.org\/content\/302\/5645\/618\" target=\"_blank\" rel=\"noopener noreferrer\">K\u00ebto protocells (para-qeliza) tani p\u00ebrmbanin gjene dhe nj\u00eb katalizator<\/a>, t\u00eb gjitha nga nj\u00eb instalim i thjesht\u00eb.<\/p>\n<p>Vendimi p\u00ebr t\u00eb shtuar montmorillonite nuk ishte b\u00ebr\u00eb me nj\u00eb trill. Disa dekada pune kishin sugjeruar se montmorillonitet, dhe <a href=\"https:\/\/link.springer.com\/article\/10.1007%2FBF01732066\" target=\"_blank\" rel=\"noopener noreferrer\">argjila si ajo<\/a>, mund t\u00eb jen\u00eb <a href=\"http:\/\/www.bbc.com\/earth\/story\/20160823-the-idea-that-life-began-as-clay-crystals-is-50-years-old\" target=\"_blank\" rel=\"noopener noreferrer\">t\u00eb r\u00ebnd\u00ebsishme n\u00eb origjin\u00ebn e jet\u00ebs<\/a>.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Ky grumbull balte - montmorillonite\" src=\"http:\/\/fjala.info\/2018\/p04clbsv.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Ky grumbull balte \u00ebsht\u00eb kryesisht montmorillonite<\/em><br \/>\n(Credit: Susan E. Degginger\/Alamy)<\/p>\n<\/blockquote>\n<p>Montmorilloniti \u00ebsht\u00eb nj\u00eb balt\u00eb e zakonshme. N\u00eb dit\u00ebt e sotme p\u00ebrdoret p\u00ebr t\u00eb gjitha llojet e gj\u00ebrave, duke p\u00ebrfshir\u00eb edhe pjell\u00ebn e maces. Formohet kur hiri vullkanik \u00ebsht\u00eb thyer nga moti. Toka e hershme kishte shum\u00eb vullkane, prandaj duket e mundshme q\u00eb montmorilloniti ishte i bollsh\u00ebm.<\/p>\n<p>Kthehemi n\u00eb vitin 1986, kimisti <a href=\"https:\/\/en.wikipedia.org\/wiki\/James_Ferris\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>James Ferris<\/strong><\/a> kishte treguar se <a href=\"https:\/\/link.springer.com\/article\/10.1007%2FBF02422142\" target=\"_blank\" rel=\"noopener noreferrer\">montmorilloniti \u00ebsht\u00eb nj\u00eb katalizator q\u00eb ndihmon formimin e molekulave organike<\/a>. M\u00eb von\u00eb ai gjeti q\u00eb <a href=\"http:\/\/rstb.royalsocietypublishing.org\/content\/361\/1474\/1777\" target=\"_blank\" rel=\"noopener noreferrer\">kjo gjithashtu p\u00ebrshpejton formimin e ARN-ve t\u00eb vogla<\/a>.<\/p>\n<p>Kjo kishte b\u00ebr\u00eb q\u00eb Ferris t\u00eb spekulonte se kjo balte e zakonshme n\u00eb k\u00ebrkim ishte vendi i origjin\u00ebs s\u00eb jet\u00ebs. Szostak mori k\u00ebt\u00eb ide dhe vrapoi me t\u00eb, duke p\u00ebrdorur montmorillonite p\u00ebr t\u00eb ndihmuar n\u00eb nd\u00ebrtimin e protocell\u00ebve t\u00eb tij.<\/p>\n<blockquote><p><em>N\u00ebse protocells (para-qelizat) mund t\u00eb rriteshin, ndoshta ato gjithashtu mund t\u00eb ndahen<\/em><\/p><\/blockquote>\n<p>Nj\u00eb vit m\u00eb von\u00eb, ekipi i Szostakut zbuloi se protocell\u00ebt e tyre mund t\u00eb rriteshin sipas marr\u00ebveshjes s\u00eb tyre.<\/p>\n<p>Si gjithnj\u00eb e m\u00eb shum\u00eb molekula t\u00eb ARN-s\u00eb u paketuan n\u00eb nj\u00eb protocell, muri i jasht\u00ebm erdhi n\u00ebn tension n\u00eb rritje. Ishte sikur protocelli t\u00eb kishte nj\u00eb stomak t\u00eb plot\u00eb dhe mund t\u00eb shkonte pop.<\/p>\n<p>P\u00ebr t\u00eb kompensuar, protocelli mori m\u00eb shum\u00eb acide yndyrore dhe i inkorporoi ato n\u00eb mur, duke e lejuar at\u00eb t\u00eb fryhej n\u00eb nj\u00eb madh\u00ebsi m\u00eb t\u00eb madhe dhe duke liruar tensionin.<\/p>\n<p>\u00c7&#8217;\u00ebsht\u00eb m\u00eb e r\u00ebnd\u00ebsishmja, iu desh\u00ebn acidet yndyrore nga protocellet e tjer\u00eb q\u00eb p\u00ebrmbanin m\u00eb pak ARN, duke i shkaktuar ato t\u00eb tkurren. Kjo do t\u00eb thot\u00eb se protocell\u00ebt ishin duke konkurruar, dhe <a href=\"http:\/\/science.sciencemag.org\/content\/305\/5689\/1474\" target=\"_blank\" rel=\"noopener noreferrer\">ato me m\u00eb shum\u00eb ARN ishin duke fituar<\/a>.<\/p>\n<p>Kjo sugjeroi di\u00e7ka edhe m\u00eb mbres\u00ebl\u00ebn\u00ebse. N\u00ebse protocell\u00ebt mund t\u00eb rriteshin, ndoshta ato gjithashtu mund t\u00eb ndaheshin. A mund t\u00eb riprodhohen protocells (para-qelizat) e Szostak?<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Qelizat riprodhohen duke u ndar\u00eb n\u00eb dy\" src=\"http:\/\/fjala.info\/2018\/p04cl4mk.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Qelizat riprodhohen duke u ndar\u00eb n\u00eb dy<\/em><br \/>\n(Credit: Science Photo Library\/Alamy)<\/p>\n<\/blockquote>\n<p>Eksperimentet e para t\u00eb Szostakut kishin treguar nj\u00eb m\u00ebnyr\u00eb p\u00ebr t\u00eb ndar\u00eb protocell\u00ebt. Shtrydhja e tyre n\u00ebp\u00ebr vrima t\u00eb vogla i shtrin\u00eb n\u00eb tuba, t\u00eb cilat m\u00eb pas hyn\u00eb n\u00eb protocellet e &#8220;vajz\u00ebs&#8221;.<\/p>\n<blockquote><p><em>Protocell\u00ebt u rrit\u00ebn dhe ndryshuan form\u00eb, duke u zgjatur n\u00eb fije t\u00eb gjata si fillestare<\/em><\/p><\/blockquote>\n<p>Kjo ishte e rregullt, sepse nuk p\u00ebrfshihej asnj\u00eb makineri qelizore: vet\u00ebm aplikimi i presionit. Por kjo nuk ishte nj\u00eb zgjidhje e madhe, sepse protocell\u00ebt kan\u00eb humbur disa nga p\u00ebrmbajtjet e tyre n\u00eb proces. Ai gjithashtu n\u00ebnkuptonte se qelizat e para mund t\u00eb ndaheshin vet\u00ebm n\u00ebse ato do t\u00eb shtyheshin n\u00ebp\u00ebr vrima t\u00eb vogla.<\/p>\n<p>Ka <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1367593104001346?via%3Dihub\" target=\"_blank\" rel=\"noopener noreferrer\">shum\u00eb m\u00ebnyra<\/a> p\u00ebr t\u00eb ndar\u00eb vezikulat: p\u00ebr shembull, duke shtuar nj\u00eb rrym\u00eb t\u00eb fort\u00eb t\u00eb ujit q\u00eb krijon nj\u00eb forc\u00eb qeth\u00ebse. Q\u00ebllimi ishte t\u00eb b\u00ebnin ndarjen e protocell\u00ebve pa e derdhur guximin e tyre.<\/p>\n<p>N\u00eb vitin 2009, Szostak dhe studentja e tij Ting Zhu gjet\u00ebn nj\u00eb zgjidhje. Ata i b\u00ebn\u00eb protocellet pak m\u00eb komplekse, me disa mure t\u00eb jashtme koncentrike pak si shtresat e nj\u00eb qepe. P\u00ebrkund\u00ebr ngat\u00ebrres\u00ebs s\u00eb tyre, k\u00ebto protocelle ishin ende t\u00eb lehta p\u00ebr t&#8217;u b\u00ebr\u00eb.<\/p>\n<p>Ashtu si Zhu i ushqeu ato me acide m\u00eb shum\u00eb yndyrore, protocells (para-qelizat) u rrit\u00ebn dhe ndryshuan form\u00eb, u b\u00ebn\u00eb m\u00eb t\u00eb gjata, si litar\u00ebt e filles\u00ebs. Pasi nj\u00eb protocell (para-qeliz\u00eb) ishte mjaft e gjat\u00eb, nj\u00eb forc\u00eb e but\u00eb prer\u00ebse ishte e mjaftueshme <a href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/ja900919c\" target=\"_blank\" rel=\"noopener noreferrer\">p\u00ebr ta b\u00ebr\u00eb at\u00eb t\u00eb ndahej n\u00eb dhjet\u00ebra protocells (para-qeliza) t\u00eb vogla vajzash<\/a>.<\/p>\n<blockquote><p>K\u00ebtu jepet nj\u00eb video, n\u00eb shkrimin origjinal n\u00eb anglisht:<br \/>\n(<em>videon shikojeni n\u00eb <a href=\"http:\/\/www.bbc.com\/earth\/story\/20161026-the-secret-of-how-life-on-earth-began\" target=\"_blank\" rel=\"noopener noreferrer\">shkrimin origjinal<\/a>, pasi nuk mund\u00ebm ta fusnim k\u00ebtu<\/em>)<\/p><\/blockquote>\n<p>\u00c7do protocell (para-qeliz\u00eb) e vajz\u00ebs p\u00ebrmbante ARN nga protocell (para-qeliza) m\u00ebm\u00eb, dhe pothuajse asnj\u00eb prej ARN-s\u00eb nuk kishte humbur. P\u00ebr m\u00eb tep\u00ebr, protocell\u00ebt mund t\u00eb kryejn\u00eb ciklin n\u00eb m\u00ebnyr\u00eb t\u00eb p\u00ebrs\u00ebritur, me rritjen e protocell\u00ebve vajza dhe pastaj me ndarjen e tyre.<\/p>\n<p>N\u00eb eksperimentet e m\u00ebvonshme, Zhu dhe Szostak kan\u00eb gjetur edhe m\u00eb shum\u00eb m\u00ebnyra <a href=\"http:\/\/www.pnas.org\/content\/109\/25\/9828\" target=\"_blank\" rel=\"noopener noreferrer\">p\u00ebr t\u00eb bindur q\u00eb protocellet t\u00eb ndahen<\/a>. Ky aspekt i problemit, t\u00eb pakt\u00ebn, duket se \u00ebsht\u00eb zgjidhur.<\/p>\n<p>Megjithat\u00eb, protocell\u00ebt ende nuk po b\u00ebnin mjaft. Luisi kishte dashur q\u00eb protocellet t\u00eb mbanin replikimin e ARN, por deri m\u00eb tani ARN ishte thjesht duke u ulur n\u00eb to, duke mos b\u00ebr\u00eb asgj\u00eb.<\/p>\n<blockquote><p><em>Kishte dyshime t\u00eb vlefshme t\u00eb varrosura n\u00eb ato letra me pluhur<\/em><\/p><\/blockquote>\n<p>P\u00ebr t\u00eb treguar me t\u00eb v\u00ebrtet\u00eb se protocell\u00ebt e tij mund t\u00eb kishin qen\u00eb jeta e par\u00eb n\u00eb Tok\u00eb, Szostak duhej t\u00eb bindte ARN brenda tyre, q\u00eb t\u00eb p\u00ebrs\u00ebris\u00eb veten.<\/p>\n<p>Kjo nuk do t\u00eb ishte e leht\u00eb, sepse pavar\u00ebsisht dekadave t\u00eb p\u00ebrpjekjes &#8211; t\u00eb p\u00ebrvijuara n\u00eb Kapitullin e Tret\u00eb &#8211; askush nuk kishte arritur t\u00eb b\u00ebnte nj\u00eb ARN, q\u00eb mund t\u00eb p\u00ebrs\u00ebriste vet\u00eb. Ky ishte problemi m\u00eb i madh, i cili e kishte penguar Szostak n\u00eb pun\u00ebn e tij t\u00eb hershme n\u00eb Bot\u00ebn e ARN-s\u00eb, dhe q\u00eb askush tjet\u00ebr nuk kishte arritur ta zgjidh\u00eb.<\/p>\n<p>Pra, ai u kthye dhe lexoi s\u00ebrish vepr\u00ebn e Leslie Orgel, i cili kishte kaluar shum\u00eb koh\u00eb p\u00ebr t\u00eb punuar n\u00eb hipotez\u00ebn e ARN-s\u00eb bot\u00ebrore. Kishte dyshime t\u00eb vlefshme t\u00eb varrosura n\u00eb ato letra me pluhur.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Qelizat e para - kimia e jet\u00ebs\" src=\"http:\/\/fjala.info\/2018\/p04dbns5.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Qelizat e para kishin p\u00ebr t\u00eb pritur kimin\u00eb e jet\u00ebs<\/em><br \/>\n(Credit: Science Photo Library\/Alamy)<\/p>\n<\/blockquote>\n<p>Orgel kishte shpenzuar shum\u00eb, vitet 1970 dhe 1980, duke studiuar se si kopjohen fillesat e ARN-s\u00eb.<\/p>\n<blockquote><p><em>Kjo mund t\u00eb kishte qen\u00eb, si jeta e par\u00eb, b\u00ebri kopje t\u00eb gjeneve t\u00eb saj<\/em><\/p><\/blockquote>\n<p>N\u00eb thelb \u00ebsht\u00eb e thjesht\u00eb. Merrni nj\u00eb fije t\u00eb vetme t\u00eb ARN dhe nj\u00eb pishin\u00eb t\u00eb nukleotideve t\u00eb lirshme. M\u00eb pas, p\u00ebrdorni ato nukleotide p\u00ebr t\u00eb mbledhur nj\u00eb brez t\u00eb dyt\u00eb t\u00eb ARN-s\u00eb, q\u00eb \u00ebsht\u00eb komplementare me at\u00eb t\u00eb par\u00eb.<\/p>\n<p>P\u00ebr shembull, nj\u00eb pjes\u00eb e ARN q\u00eb lexon &#8220;CGC&#8221; do t\u00eb prodhoj\u00eb nj\u00eb filles\u00eb plot\u00ebsuese q\u00eb lexon &#8220;GCG&#8221;. N\u00ebse e b\u00ebni k\u00ebt\u00eb dy her\u00eb, do t\u00eb merrni nj\u00eb kopje t\u00eb origjinalit &#8220;CGC&#8221;, vet\u00ebm n\u00eb nj\u00eb rrug\u00eb t\u00eb t\u00ebrthort\u00eb.<\/p>\n<p>Orgel zbuloi se, n\u00eb rrethana t\u00eb caktuara, fillesat e ARN-s\u00eb, mund t\u00eb kopjohen n\u00eb k\u00ebt\u00eb m\u00ebnyr\u00eb, pa ndonj\u00eb ndihm\u00eb nga enzimat. Kjo mund t\u00eb kishte qen\u00eb, si jeta e par\u00eb, b\u00ebri kopje t\u00eb gjeneve t\u00eb saj.<\/p>\n<p>Deri n\u00eb vitin 1987, Orgel mund t\u00eb merrte nj\u00eb FNK t\u00eb gjat\u00eb 14 nukleotide dhe t\u00eb <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/0022283687901173?via%3Dihub\" target=\"_blank\" rel=\"noopener noreferrer\">krijonte fije komplementare q\u00eb ishin gjithashtu 14 nukleotide t\u00eb gjata<\/a>. Ai nuk arriti asgj\u00eb m\u00eb gjat\u00eb, por <a href=\"https:\/\/jsystchem.springeropen.com\/articles\/10.1186\/1759-2208-3-2\" target=\"_blank\" rel=\"noopener noreferrer\">kjo ishte e mjaftueshme p\u00ebr t\u00eb intriguar Szostak<\/a>. Studenti i tij Katarzyna Adamala u p\u00ebrpoq t\u00eb merrte k\u00ebt\u00eb reagim duke shkuar te protocellet.<\/p>\n<blockquote><p><em>Ata kan\u00eb nd\u00ebrtuar protocellet q\u00eb mbajn\u00eb gjenet e tyre, duke marr\u00eb molekula t\u00eb dobishme nga jasht\u00eb<\/em><\/p><\/blockquote>\n<p>Ata gjet\u00ebn se reagimi kishte nevoj\u00eb p\u00ebr magnezin p\u00ebr t\u00eb punuar, gj\u00eb q\u00eb ishte nj\u00eb problem sepse magnezi shkat\u00ebrron protocell\u00ebt. Por ka pasur nj\u00eb zgjidhje t\u00eb thjesht\u00eb: citrate, e cila \u00ebsht\u00eb pothuajse identike me acidin limonik n\u00eb limon dhe portokall, dhe q\u00eb gjendet gjithsesi n\u00eb t\u00eb gjitha qelizat e gjalla.<\/p>\n<p><a href=\"http:\/\/science.sciencemag.org\/content\/342\/6162\/1098\" target=\"_blank\" rel=\"noopener noreferrer\">N\u00eb nj\u00eb studim t\u00eb publikuar n\u00eb vitin 2013<\/a>, ata shtuan citrate dhe zbuluan se ajo u mb\u00ebrthye n\u00eb magnez, duke mbrojtur protocellet, duke lejuar kopjimin e modelit q\u00eb t\u00eb vazhdoj\u00eb.<\/p>\n<p>Me fjal\u00eb t\u00eb tjera, ata kishin arritur at\u00eb q\u00eb Luisi kishte propozuar n\u00eb vitin 1994. &#8220;<em>Kemi filluar t\u00eb b\u00ebjm\u00eb kimin\u00eb e replikimit t\u00eb ARN-s\u00eb brenda k\u00ebtyre vezikulave t\u00eb acideve yndyrore<\/em>&#8220;, thot\u00eb Szostak.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Para-qelizat e Szostakut mbijetojn\u00eb me nxeht\u00ebsi\" src=\"http:\/\/fjala.info\/2018\/p04cl9qx.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Protocells (para-qelizat) e Szostakut mund t\u00eb mbijetojn\u00eb me nxeht\u00ebsi ekstreme<\/em><br \/>\n(Credit: Jon Sullivan, PDPhoto.org)<\/p>\n<\/blockquote>\n<p>N\u00eb pak m\u00eb shum\u00eb se nj\u00eb dekad\u00eb hulumtimi, ekipi i Szostak ka arritur di\u00e7ka t\u00eb jasht\u00ebzakonshme.<\/p>\n<p>Ata kan\u00eb nd\u00ebrtuar protocellet q\u00eb mbajn\u00eb gjenet e tyre, duke marr\u00eb molekula t\u00eb dobishme nga jasht\u00eb. Protocell\u00ebt mund t\u00eb rriten dhe t\u00eb ndahen, madje edhe t\u00eb konkurrojn\u00eb me nj\u00ebri-tjetrin. ARN mund t\u00eb p\u00ebrs\u00ebritet brenda tyre. Me \u00e7do mas\u00eb, ata jan\u00eb befasues t\u00eb jet\u00ebs.<\/p>\n<blockquote><p><em>Qasja e Szostakut shkoi p\u00ebr 40 vjet pun\u00eb n\u00eb origjin\u00ebn e jet\u00ebs<\/em><\/p><\/blockquote>\n<p>Ato jan\u00eb gjithashtu elastike. N\u00eb vitin 2008, ekipi i Szostak zbuloi se <a href=\"http:\/\/www.pnas.org\/content\/105\/36\/13351\" target=\"_blank\" rel=\"noopener noreferrer\">protocell\u00ebt mund t\u00eb mbijetonin, duke u nxehur n\u00eb 100<sup>o<\/sup>C<\/a>, nj\u00eb temperatur\u00eb q\u00eb do t\u00eb zhdukte qelizat m\u00eb moderne. Kjo e nxiti rastin q\u00eb t\u00eb besohej se protocellet ishin t\u00eb ngjashme me jet\u00ebn e par\u00eb, t\u00eb cilat duhet ta kishin duruar nxeht\u00ebsin\u00eb p\u00ebrv\u00ebluese nga ndikimet e vazhdueshme t\u00eb meteoreve.<\/p>\n<p>&#8220;<em>Szostak po b\u00ebn pun\u00eb t\u00eb madhe<\/em>&#8220;, thot\u00eb Armen Mulkidjanian.<\/p>\n<p>Megjithat\u00eb, n\u00eb fytyr\u00ebn e saj, qasja e Szostak u kund\u00ebrp\u00ebrgjigj 40 vjet pun\u00eb n\u00eb origjin\u00ebn e jet\u00ebs. N\u00eb vend q\u00eb t\u00eb p\u00ebrq\u00ebndrohej n\u00eb &#8220;replikimin e par\u00eb&#8221; ose n\u00eb &#8220;ndarjen e par\u00eb&#8221;, ai gjeti m\u00ebnyra p\u00ebr t&#8217;i b\u00ebr\u00eb t\u00eb dyja t\u00eb ndodhin pothuajse nj\u00ebkoh\u00ebsisht.<\/p>\n<p>Kjo do t\u00eb frym\u00ebzonte nj\u00eb qasje t\u00eb re t\u00eb unifikuar ndaj origjin\u00ebs s\u00eb jet\u00ebs, e cila p\u00ebrpiqet t\u00eb filloj\u00eb menj\u00ebher\u00eb t\u00eb gjitha funksionet e jet\u00ebs. Kjo ide &#8220;\u00e7do gj\u00eb e par\u00eb&#8221; tashm\u00eb ka grumbulluar nj\u00eb pasuri t\u00eb dh\u00ebnash dhe mund t\u00eb zgjidh\u00eb potencialisht t\u00eb gjitha problemet me idet\u00eb ekzistuese.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Molekulat e jet\u00ebs - tep\u00ebr komplekse\" src=\"http:\/\/fjala.info\/2018\/p04cl3sr.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Molekulat e jet\u00ebs sillen n\u00eb m\u00ebnyr\u00eb tep\u00ebr komplekse<\/em><br \/>\n(Credit: Equinox Graphics Ltd)<\/p>\n<\/blockquote>\n<p><strong>Kapitulli 6. Bashkimi i madh<\/strong><\/p>\n<p><em>Gjat\u00eb gjysm\u00ebs s\u00eb dyt\u00eb t\u00eb shekullit t\u00eb 20-t\u00eb, studiuesit e origjin\u00ebs s\u00eb jet\u00ebs kan\u00eb punuar n\u00eb fise. Secili grup favorizonte tregimin e vet dhe, n\u00eb pjes\u00ebn m\u00eb t\u00eb madhe, i fshihte hipotezat konkurruese. Kjo qasje sigurisht q\u00eb ka qen\u00eb e suksesshme, si\u00e7 d\u00ebshmohet nga kapitujt e m\u00ebparsh\u00ebm, por \u00e7do ide premtuese p\u00ebr origjin\u00ebn e jet\u00ebs, ka ardhur n\u00eb fund t\u00eb fundit kund\u00ebr nj\u00eb problemi t\u00eb madh. Pra, disa k\u00ebrkues tani po p\u00ebrpiqen t\u00eb gjejn\u00eb nj\u00eb qasje m\u00eb t\u00eb bashkuar.<\/em><\/p>\n<p>Kjo ide mori nxitjen e saj t\u00eb par\u00eb t\u00eb madhe disa vjet m\u00eb par\u00eb nga nj\u00eb rezultat q\u00eb, n\u00eb pamjen e par\u00eb, dukej se mb\u00ebshteste RNA tradicionale, replikimin e par\u00eb t\u00eb ARN-s\u00eb.<\/p>\n<blockquote><p><em>T\u00eb gjith\u00eb komponent\u00ebt kryesor\u00eb t\u00eb jet\u00ebs mund t\u00eb formoheshin menj\u00ebher\u00eb<\/em><\/p><\/blockquote>\n<p>Deri n\u00eb vitin 2009, mb\u00ebshtet\u00ebsit e RNA Bot\u00ebrore kishin nj\u00eb problem t\u00eb madh. Ata nuk mund t\u00eb b\u00ebnin nukleotide, blloqet e nd\u00ebrtimit t\u00eb ARN, n\u00eb nj\u00eb m\u00ebnyr\u00eb q\u00eb mund t\u00eb kishte ndodhur n\u00eb Tok\u00ebn e hershme. Kjo, si\u00e7 m\u00ebsuam n\u00eb kapitullin e tret\u00eb, nxorri njer\u00ebzit q\u00eb t\u00eb dyshonin se jeta e par\u00eb nuk ishte e bazuar n\u00eb ARN fare.<\/p>\n<p><em>John Sutherland<\/em> kishte menduar p\u00ebr k\u00ebt\u00eb problem q\u00eb nga viti 1980. &#8220;<em>Mendova, n\u00ebse mund t\u00eb demonstrosh se ARN mund t\u00eb mblidhej vet\u00eb, kjo do t\u00eb ishte nj\u00eb gj\u00eb e mir\u00eb p\u00ebr t\u00eb b\u00ebr\u00eb<\/em>&#8220;, thot\u00eb ai.<\/p>\n<p>P\u00ebr fat t\u00eb mir\u00eb p\u00ebr Sutherland, ai kishte siguruar nj\u00eb pun\u00eb n\u00eb Laboratorin e Biologjis\u00eb Molekulare (LMB) n\u00eb Kembrixh, Britani e Madhe. Shumica e institucioneve k\u00ebrkimore detyrojn\u00eb stafin e tyre q\u00eb t\u00eb p\u00ebrhape vazhdimisht gjetjet e reja, por LMB nuk e b\u00ebn. Pra Sutherland mund t\u00eb mendonte p\u00ebrse ishte kaq e v\u00ebshtir\u00eb p\u00ebr t\u00eb b\u00ebr\u00eb nj\u00eb nukleotid t\u00eb ARN-s\u00eb dhe p\u00ebr t\u00eb kaluar vite duke zhvilluar nj\u00eb qasje alternative.<\/p>\n<p>Zgjidhja e tij do ta \u00e7onte at\u00eb t\u00eb propozonte nj\u00eb ide t\u00eb re radikale p\u00ebr origjin\u00ebn e jet\u00ebs, dometh\u00ebn\u00eb q\u00eb t\u00eb gjitha komponent\u00ebt kryesor\u00eb t\u00eb jet\u00ebs mund t\u00eb formoheshin menj\u00ebher\u00eb.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Toka i vetmi vend, ku ka jet\u00eb\" src=\"http:\/\/fjala.info\/2018\/p04cl350.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Toka \u00ebsht\u00eb i vetmi vend, ku kemi gjetur jet\u00eb<\/em><br \/>\n(Credit: Nasa)<\/p>\n<\/blockquote>\n<p>&#8220;<em>Kishte aspekte t\u00eb caktuara ky\u00e7e t\u00eb kimis\u00eb s\u00eb ARN-s\u00eb, q\u00eb nuk funksiononin<\/em>&#8220;, thot\u00eb Sutherland. \u00c7do nukleotid i ARN-s\u00eb \u00ebsht\u00eb b\u00ebr\u00eb nga nj\u00eb sheqer, nj\u00eb baz\u00eb dhe nj\u00eb fosfat. Por ishte e pamundur t\u00eb bind\u00ebsh sheqerin dhe baz\u00ebn p\u00ebr t&#8217;u bashkuar. Molekulat ishin thjesht forma e gabuar.<\/p>\n<blockquote><p><em>Ai beson se ARN ishte i p\u00ebrfshir\u00eb shum\u00eb, por nuk ishte t\u00eb jesh-e gjitha-dhe-fund-e gjitha<\/em><\/p><\/blockquote>\n<p>Pra Sutherland filloi t\u00eb provonte substanca krejt\u00ebsisht t\u00eb ndryshme. P\u00ebrfundimisht ekipi i tij vendosi pes\u00eb molekula t\u00eb thjeshta, duke p\u00ebrfshir\u00eb nj\u00eb sheqer dhe cianamid t\u00eb ndrysh\u00ebm, q\u00eb si\u00e7 sugjeron emri lidhet me cianidin. Ekipi i vuri k\u00ebto kimikate <a href=\"https:\/\/www.nature.com\/articles\/nature08013.epdf\" target=\"_blank\" rel=\"noopener noreferrer\">n\u00ebp\u00ebrmjet nj\u00eb s\u00ebr\u00eb reaksionesh<\/a>, q\u00eb p\u00ebrfundimisht prodhuan dy nga kat\u00ebr nukleotide t\u00eb ARN-s\u00eb, pa b\u00ebr\u00eb ndonj\u00ebher\u00eb sheqernat ose bazat e pavarura.<\/p>\n<p>Ishte nj\u00eb sukses i d\u00ebshtuar, dhe e b\u00ebri me em\u00ebr Sutherlandin.<\/p>\n<p>Shum\u00eb v\u00ebzhgues i interpretuan gjetjet si <a href=\"https:\/\/www.newscientist.com\/article\/mg21128251-300-first-life-the-search-for-the-first-replicator\/\" target=\"_blank\" rel=\"noopener noreferrer\">d\u00ebshmi t\u00eb m\u00ebtejshme p\u00ebr bot\u00ebn e ARN-s\u00eb<\/a>. Por vet\u00eb Sutherlandi nuk e sheh at\u00eb fare.<\/p>\n<p>Hipoteza &#8220;klasike&#8221; e ARN-s\u00eb thot\u00eb se, n\u00eb organizmat e par\u00eb, ARN ishte p\u00ebrgjegj\u00ebse p\u00ebr t\u00eb gjitha funksionet e jet\u00ebs. Por Sutherland thot\u00eb se \u00ebsht\u00eb &#8220;optimist pa shpres\u00eb&#8221;. Ai beson se ARN ishte i p\u00ebrfshir\u00eb shum\u00eb, por nuk ishte t\u00eb jesh-e gjitha-dhe-fund-e gjitha.<\/p>\n<blockquote><p><em>Molekulat ishin thjesht forma t\u00eb gabuara<\/em><\/p><\/blockquote>\n<p>N\u00eb vend t\u00eb k\u00ebsaj, ai merr frym\u00ebzim nga puna e fundit e Jack Szostak, e cila, si\u00e7 diskutohet n\u00eb Kapitullin e Pest\u00eb, kombinon &#8220;ARN&#8221; bot\u00ebrore t\u00eb &#8220;replikimit t\u00eb par\u00eb&#8221; me &#8220;kompartmentalizimin e par\u00eb&#8221; t\u00eb Pier Luigi Luisit.<\/p>\n<p>Por Sutherland shkon m\u00eb tej. Qasja e tij \u00ebsht\u00eb &#8220;gjith\u00e7ka-s\u00eb pari&#8221;. Ai synon t\u00eb mbledh\u00eb nj\u00eb qeliz\u00eb t\u00eb t\u00ebr\u00eb, nga e para.<\/p>\n<p>Gjurma e tij e par\u00eb ishte nj\u00eb detaj i \u00e7uditsh\u00ebm p\u00ebr sintez\u00ebn e tij nukleotide, e cila fillimisht dukej e rast\u00ebsishme.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Jeta ka nevoj\u00eb p\u00ebr nj\u00eb p\u00ebrzierje kimikatesh\" src=\"http:\/\/fjala.info\/2018\/p04dbrhv.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Jeta ka nevoj\u00eb p\u00ebr nj\u00eb p\u00ebrzierje t\u00eb gjer\u00eb t\u00eb kimikateve<\/em><br \/>\n(Credit: Science Lab\/Alamy)<\/p>\n<\/blockquote>\n<p>Hapi i fundit n\u00eb procesin e Sutherland ishte p\u00ebr t\u00eb rrokullisur nj\u00eb fosfat mbi nukleotid. Por ai gjeti se ishte mir\u00eb ta p\u00ebrfshinte fosfatin n\u00eb p\u00ebrzierje q\u00eb nga fillimi, sepse p\u00ebrshpejtonte reagimet e m\u00ebparshme.<\/p>\n<p>N\u00eb pamje t\u00eb par\u00eb, p\u00ebrfshirja e fosfatit para se t\u00eb ishte e nevojshme, ishte nj\u00eb gj\u00eb e \u00e7rregullt p\u00ebr ta b\u00ebr\u00eb, por Sutherland zbuloi se ky \u00e7rregullim ishte nj\u00eb gj\u00eb e mir\u00eb.<\/p>\n<blockquote><p><em>Merrni nj\u00eb p\u00ebrzierje mjaft t\u00eb komplikuar dhe t\u00eb gjitha komponent\u00ebt e jet\u00ebs mund t\u00eb formohen aty n\u00eb t\u00eb nj\u00ebjt\u00ebn koh\u00eb<\/em><\/p><\/blockquote>\n<p>Kjo e b\u00ebri at\u00eb t\u00eb mendonte se si do t\u00eb duhej t\u00eb ishin t\u00eb \u00e7rregullta p\u00ebrzierjet e tij. N\u00eb Tok\u00ebn e hershme, duhet t\u00eb ket\u00eb pasur dhjetra ose qindra kimikate t\u00eb gjitha q\u00eb lundrojn\u00eb p\u00ebrreth s\u00eb bashku. Kjo ting\u00ebllon si nj\u00eb recet\u00eb p\u00ebr nj\u00eb llum, por ndoshta ka pasur nj\u00eb nivel optimal t\u00eb rr\u00ebmuj\u00ebs.<\/p>\n<p>P\u00ebrzierjet e b\u00ebra nga Stanley Miller n\u00eb vitet 1950, t\u00eb cilat ne i pam\u00eb n\u00eb Kapitullin e 1-r\u00eb, ishin shum\u00eb m\u00eb t\u00eb shqet\u00ebsuara sesa ato t\u00eb Sutherland. Ata p\u00ebrmbanin molekula biologjike, por Sutherland thot\u00eb se ata &#8220;<em>ishin n\u00eb sasi t\u00eb madhe dhe u shoq\u00ebruan nga nj\u00eb num\u00ebr i madh i p\u00ebrb\u00ebrjeve t\u00eb tjera, t\u00eb cilat nuk jan\u00eb biologjike<\/em>&#8220;.<\/p>\n<p>P\u00ebr Sutherland, kjo do t\u00eb thoshte se p\u00ebrzierja e Miller nuk ishte mjaft e mir\u00eb. Ishte shum\u00eb e \u00e7rregullt, k\u00ebshtu q\u00eb kimikatet e mira humb\u00ebn n\u00eb p\u00ebrzierje.<\/p>\n<p>Pra, Sutherland ka nisur t\u00eb gjej\u00eb nj\u00eb &#8220;kimi t\u00eb Goldilocks&#8221;: nj\u00eb q\u00eb nuk \u00ebsht\u00eb aq e \u00e7oroditur sa t\u00eb b\u00ebhet e padobishme, por jo aq e thjesht\u00eb, saq\u00eb \u00ebsht\u00eb e kufizuar n\u00eb at\u00eb q\u00eb mund t\u00eb b\u00ebj\u00eb. Merrni p\u00ebrzierjen mjaft t\u00eb komplikuar dhe t\u00eb gjitha komponent\u00ebt e jet\u00ebs mund t\u00eb formohen menj\u00ebher\u00eb, pastaj bashkohen.<\/p>\n<p>Me fjal\u00eb t\u00eb tjera, kat\u00ebr miliard vjet m\u00eb par\u00eb kishte nj\u00eb pellg n\u00eb Tok\u00eb. Ajo q\u00ebndroi atje p\u00ebr vite t\u00eb t\u00ebra, derisa p\u00ebrzierja e kimikateve ishte ajo q\u00eb duhej. Pastaj, ndoshta brenda disa minutave, qeliza e par\u00eb erdhi n\u00eb ekzistenc\u00eb.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Nj\u00eb grusht kimikatesh nuk mjaftojn\u00eb\" src=\"http:\/\/fjala.info\/2018\/p04cl2h7.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Nj\u00eb grusht kimikatesh nuk mjaftojn\u00eb p\u00ebr ta b\u00ebr\u00eb jet\u00ebn<\/em><br \/>\n(Credit: JG Photography\/Alamy)<\/p>\n<\/blockquote>\n<p>Kjo mund t\u00eb ting\u00eblloj\u00eb si e papranueshme, si pretendimet e alkimist\u00ebve mesjetar\u00eb. Por d\u00ebshmia e Sutherland \u00ebsht\u00eb n\u00eb rritje. Q\u00eb nga viti 2009, ai ka treguar se e nj\u00ebjta kimik\u00eb, q\u00eb ka b\u00ebr\u00eb dy nukleotidet e tij t\u00eb ARN-s\u00eb, mundet gjithashtu t\u00eb b\u00ebj\u00eb shum\u00eb nga molekulat e tjera t\u00eb jet\u00ebs.<\/p>\n<blockquote><p><em>Qasja jon\u00eb e t\u00ebr\u00eb ndaj origjin\u00ebs s\u00eb jet\u00ebs p\u00ebr 40 vitet e fundit ka qen\u00eb e gabuar<\/em><\/p><\/blockquote>\n<p>Hapi tjet\u00ebr i duksh\u00ebm ishte p\u00ebr t\u00eb b\u00ebr\u00eb m\u00eb shum\u00eb nukleotide t\u00eb ARN-s\u00eb. Ai ende nuk e ka arritur k\u00ebt\u00eb, por n\u00eb vitin 2010 <a href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/ja108197s\" rel=\"noopener noreferrer\" target=\"_blank\">ai krijoi molekula t\u00eb af\u00ebrta<\/a>, q\u00eb potencialisht mund t\u00eb transformoheshin n\u00eb nukleotide.<\/p>\n<p>N\u00eb m\u00ebnyr\u00eb t\u00eb ngjashme, n\u00eb vitin 2013 ai krijoi pararend\u00ebsit e aminoacideve. K\u00ebt\u00eb her\u00eb <a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.201300321\/abstract;jsessionid=F644935AACEEDE44FC3B4C2A6433918A.f01t01\" rel=\"noopener noreferrer\" target=\"_blank\">ai duhej t\u00eb shtonte cianidin e bakrit<\/a>, p\u00ebr t\u00eb b\u00ebr\u00eb reaksionet.<\/p>\n<p>Kimikatet e lidhura me cianide po provonin t\u00eb ishin nj\u00eb tem\u00eb e zakonshme, dhe n\u00eb vitin 2015, Sutherland i mori ato edhe m\u00eb tej. Ai tregoi se e nj\u00ebjta en\u00eb me kimikate mund t\u00eb prodhonte edhe <a href=\"https:\/\/www.nature.com\/articles\/nchem.2202.epdf\" rel=\"noopener noreferrer\" target=\"_blank\">pararend\u00ebsit e lipideve<\/a>, molekulat q\u00eb p\u00ebrb\u00ebjn\u00eb murin qelizor. Reagimet u nxit\u00ebn t\u00eb gjitha nga drita ultravjollc\u00eb, p\u00ebrfshinin squfur, dhe u mb\u00ebshtet\u00ebn n\u00eb bak\u00ebr, p\u00ebr t&#8217;i shpejtuar ato.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Jeta - koktej i pasur prej kimikatesh\" src=\"http:\/\/fjala.info\/2018\/p04cl9tp.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Jeta ka nevoj\u00eb p\u00ebr nj\u00eb koktej t\u00eb pasur prej kimikatesh p\u00ebr t&#8217;u formuar<\/em><br \/>\n(Credit: Radius Images\/Alamy)<\/p>\n<\/blockquote>\n<p>&#8220;<em>T\u00eb gjitha blloqet e nd\u00ebrtimit [dalin] nga nj\u00eb b\u00ebrtham\u00eb e p\u00ebrbashk\u00ebt e reaksioneve kimike<\/em>&#8220;, thot\u00eb Szostak.<\/p>\n<blockquote><p><em>Eksperimentet ishin shum\u00eb t\u00eb pastra<\/em><\/p><\/blockquote>\n<p>N\u00ebse Sutherland ka t\u00eb drejt\u00eb, at\u00ebher\u00eb gjith\u00eb qasja jon\u00eb ndaj origjin\u00ebs s\u00eb jet\u00ebs p\u00ebr 40 vitet e fundit ka qen\u00eb e gabuar. Q\u00eb kur kompleksiteti absolut i qeliz\u00ebs u b\u00eb i qart\u00eb, shkenc\u00ebtar\u00ebt kan\u00eb punuar me supozimin se, qelizat e para duhet t\u00eb jen\u00eb nd\u00ebrtuar gradualisht, nj\u00eb pjes\u00eb n\u00eb nj\u00eb koh\u00eb.<\/p>\n<p>Pas propozimit t\u00eb Leslie Orgel q\u00eb ARN erdhi e para, hulumtuesit kan\u00eb qen\u00eb &#8220;<em>p\u00ebrpjekur t\u00eb marrin nj\u00eb gj\u00eb p\u00ebrpara nj\u00eb gj\u00ebje tjet\u00ebr, dhe pastaj ta shpikin tjetr\u00ebn<\/em>&#8220;, thot\u00eb Sutherland. Por ai mendon se m\u00ebnyra m\u00eb e mir\u00eb \u00ebsht\u00eb t\u00eb b\u00ebsh gjith\u00e7ka menj\u00ebher\u00eb, n\u00eb t\u00eb nj\u00ebjt\u00ebn koh\u00eb.<\/p>\n<p>&#8220;<em>Ajo q\u00eb kemi b\u00ebr\u00eb, \u00ebsht\u00eb ta sfidojm\u00eb iden\u00eb se \u00ebsht\u00eb shum\u00eb e komplikuar t\u00eb b\u00ebjm\u00eb gjith\u00e7ka n\u00eb nj\u00eb her\u00eb<\/em>&#8220;, thot\u00eb Sutherland. &#8220;<em>Ju me siguri mund t&#8217;i b\u00ebni blloqet e nd\u00ebrtimit p\u00ebr t\u00eb gjitha sistemet n\u00eb t\u00eb nj\u00ebjt\u00ebn koh\u00eb<\/em>.&#8221;<\/p>\n<p>Szostak tani dyshon se shumica e p\u00ebrpjekjeve p\u00ebr t\u00eb b\u00ebr\u00eb molekulat e jet\u00ebs dhe p\u00ebr t&#8217;i bashkuar ato n\u00eb qelizat e gjalla, kan\u00eb d\u00ebshtuar p\u00ebr t\u00eb nj\u00ebjt\u00ebn arsye: <strong>eksperimentet ishin shum\u00eb t\u00eb pastra<\/strong>.<\/p>\n<blockquote><p><em>Un\u00eb kam ardhur me t\u00eb v\u00ebrtet\u00eb n\u00eb iden\u00eb se polimeri i par\u00eb ishte di\u00e7ka shum\u00eb e af\u00ebrt me ARN<\/em><\/p><\/blockquote>\n<p>Shkenc\u00ebtar\u00ebt p\u00ebrdor\u00ebn disa nga kimikatet q\u00eb ata ishin t\u00eb interesuar dhe i lan\u00eb t\u00eb gjitha ato, q\u00eb ndoshta ishin t\u00eb pranishme n\u00eb Tok\u00ebn e hershme. Por puna e Sutherland tregon se, <a href=\"http:\/\/rstb.royalsocietypublishing.org\/content\/366\/1580\/2894\" rel=\"noopener noreferrer\" target=\"_blank\">duke shtuar nj\u00eb ose m\u00eb shum\u00eb kimikate n\u00eb p\u00ebrzierje<\/a>, mund t\u00eb krijohen fenomene m\u00eb komplekse.<\/p>\n<p>Szostak e p\u00ebrjetoi k\u00ebt\u00eb p\u00ebr vete n\u00eb vitin 2005, kur ai po p\u00ebrpiqej t\u00eb merrte protocell\u00ebt e tij p\u00ebr t\u00eb organizuar nj\u00eb enzim\u00eb t\u00eb ARN. Enzima kishte nevoj\u00eb p\u00ebr magnez, i cili i shkat\u00ebrroi membranat e protocell\u00ebve.<\/p>\n<p>Zgjidhja ishte e habitshme. N\u00eb vend q\u00eb t&#8217;i b\u00ebnin vezikulat nga nj\u00eb acid yndyror i past\u00ebr, <a href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/ja051784p\" rel=\"noopener noreferrer\" target=\"_blank\">ata i b\u00ebn\u00eb ato nga nj\u00eb p\u00ebrzierje e dy acideve<\/a>. K\u00ebto vezikula t\u00eb reja t\u00eb papastra mund ta p\u00ebrballonin magnezin &#8211; dhe kjo do t\u00eb thoshte se ata mund t\u00eb luajn\u00eb rolin e tyre tek enzimat e ARN-s\u00eb q\u00eb t\u00eb punojn\u00eb.<\/p>\n<p>P\u00ebr m\u00eb tep\u00ebr, Szostak thot\u00eb se gjenet e para mund t\u00eb ken\u00eb p\u00ebrqafuar edhe rr\u00ebmuj\u00ebn, \u00e7&#8217;rregullimet.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"ADN-ja p\u00ebrb\u00ebhet nga molekula m\u00eb t\u00eb vogla\" src=\"http:\/\/fjala.info\/2018\/p04cl1yd.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>ADN-ja p\u00ebrb\u00ebhet nga molekula m\u00eb t\u00eb vogla, t\u00eb quajtura nukleotide<\/em><br \/>\n(Credit: Equinox Graphics Ltd)<\/p>\n<\/blockquote>\n<p>Organizmat moderne p\u00ebrdorin ADN t\u00eb past\u00ebr p\u00ebr t\u00eb mbartur gjenet e tyre, por ADN-ja e past\u00ebr ndoshta nuk ekzistonte n\u00eb fillim. Nuk do t\u00eb kishte qen\u00eb nj\u00eb p\u00ebrzierje e nukleotideve t\u00eb ARN-s\u00eb dhe nukleotideve t\u00eb ADN-s\u00eb.<\/p>\n<p>N\u00eb vitin 2012, Szostak tregoi se <a href=\"http:\/\/www.pnas.org\/content\/108\/33\/13492\" rel=\"noopener noreferrer\" target=\"_blank\">nj\u00eb p\u00ebrzierje e till\u00eb mund t\u00eb mblidhej n\u00eb molekulat &#8220;mozaik&#8221;<\/a>, q\u00eb dukeshin se sillen m\u00eb shum\u00eb si ARN i past\u00ebr. K\u00ebto zinxhir\u00eb t\u00eb ARN \/ ADN-s\u00eb t\u00eb ngat\u00ebrruar mund t\u00eb palosen me kujdes.<\/p>\n<blockquote><p><em>Ka nj\u00eb problem, q\u00eb as Sutherland as Szostak, nuk kan\u00eb gjetur nj\u00eb zgjidhje p\u00ebr t\u00eb<\/em><\/p><\/blockquote>\n<p>Kjo sugjeroi at\u00eb, q\u00eb nuk kishte r\u00ebnd\u00ebsi n\u00ebse organizmat e par\u00eb nuk mund t\u00eb b\u00ebnin ARN t\u00eb past\u00ebr, ose ADN t\u00eb past\u00ebr. &#8220;<em>Un\u00eb jam kthyer me t\u00eb v\u00ebrtet\u00eb te ideja, se polimeri i par\u00eb ishte di\u00e7ka mjaft af\u00ebr ARN-s\u00eb, nj\u00eb version i p\u00ebrzier i ARN-s\u00eb<\/em>&#8220;, thot\u00eb Szostak.<\/p>\n<p>Nuk mund t\u00eb ket\u00eb vend edhe p\u00ebr alternativat e ARN-s\u00eb, q\u00eb jan\u00eb gatuar n\u00eb laborator\u00eb, si TNA dhe PNA, q\u00eb i takuam n\u00eb Kapitullin Tre. Ne nuk e dim\u00eb n\u00ebse ndonj\u00ebri prej tyre ka ekzistuar ndonj\u00ebher\u00eb n\u00eb Tok\u00eb, por n\u00ebse ato u krijuan, organizmat e par\u00eb mund t&#8217;i ken\u00eb p\u00ebrdorur ato p\u00ebrkrah ARN-s\u00eb.<\/p>\n<p>Kjo nuk ishte nj\u00eb RNA Bot\u00ebrore: ajo ishte nj\u00eb &#8220;<a href=\"https:\/\/www.newscientist.com\/article\/dn21335-before-dna-before-rna-life-in-the-hodge-podge-world\/\" rel=\"noopener noreferrer\" target=\"_blank\">Hodge-Podge World<\/a>&#8221; (<em>bot\u00eb e p\u00ebrzier<\/em>).<\/p>\n<p>M\u00ebsimi nga k\u00ebto studime \u00ebsht\u00eb se b\u00ebrja e qeliz\u00ebs s\u00eb par\u00eb mund t\u00eb mos ket\u00eb qen\u00eb aq e v\u00ebshtir\u00eb sa nj\u00ebher\u00eb dukej. Po, qelizat jan\u00eb makina t\u00eb nd\u00ebrlikuara. Por rezulton se ata ende punojn\u00eb, megjith\u00ebse jo aq mir\u00eb, kur ata jan\u00eb hedhur s\u00eb bashku <em>slapdash<\/em> (<em>shkeleshko<\/em>) nga \u00e7do gj\u00eb q\u00eb ke n\u00eb dor\u00eb.<\/p>\n<p>Qelizat e tilla t\u00eb mprehta mund t\u00eb duket e pamundur p\u00ebr t\u00eb mbijetuar n\u00eb Tok\u00ebn e hershme. Por ato nuk do t\u00eb kishin shum\u00eb konkurrenc\u00eb dhe nuk kishte grabitqar\u00eb k\u00ebrc\u00ebnues, k\u00ebshtu q\u00eb n\u00eb shum\u00eb aspekte jeta mund t\u00eb ket\u00eb qen\u00eb m\u00eb e leht\u00eb at\u00ebher\u00eb, se sa tani.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Toka u godit nga meteor\u00ebt\" src=\"http:\/\/fjala.info\/2018\/p04cl2mh.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Toka u godit nga meteor\u00ebt n\u00eb vitet e para<\/em><br \/>\n(Credit: Chris Butler\/Science Photo Library)<\/p>\n<\/blockquote>\n<p>Ekziston nj\u00eb problem, q\u00eb as Sutherland e as Szostak nuk kan\u00eb gjetur nj\u00eb zgjidhje p\u00ebr t\u00eb, dhe kjo \u00ebsht\u00eb nj\u00eb gj\u00eb e madhe. Organizmi i par\u00eb duhet t\u00eb ket\u00eb pasur nj\u00eb form\u00eb t\u00eb metabolizmit. Q\u00eb nga fillimi, jeta duhej t\u00eb <a href=\"http:\/\/rsob.royalsocietypublishing.org\/content\/3\/11\/130156\" rel=\"noopener noreferrer\" target=\"_blank\">merrte energji<\/a>, ose do t\u00eb kishte vdekur.<\/p>\n<blockquote><p><em>Jeta mund t\u00eb ket\u00eb qen\u00eb m\u00eb e leht\u00eb at\u00ebher\u00eb, se sa tani<\/em><\/p><\/blockquote>\n<p>N\u00eb at\u00eb pik\u00eb, n\u00ebse nuk ka asgj\u00eb tjet\u00ebr, Sutherland pajtohet me Mike Russell, Bill Martin dhe mb\u00ebshtet\u00ebsit e tjer\u00eb t\u00eb teorive t\u00eb para t\u00eb metabolizmit t\u00eb Kapitullit Kat\u00ebr. &#8220;<em>Nd\u00ebrsa djemt\u00eb e ARN-s\u00eb po luftonin me djemt\u00eb e metabolizmit, t\u00eb dyja pal\u00ebt kishin nj\u00eb pik\u00eb t\u00eb p\u00ebrbashk\u00ebt<\/em>&#8220;, thot\u00eb Sutherland.<\/p>\n<p>&#8220;<em>Origjina e metabolizmit duhet t\u00eb jet\u00eb atje disi<\/em>,&#8221; thot\u00eb Szostak. &#8220;<em>Burimi i energjis\u00eb kimike do t\u00eb jet\u00eb \u00e7\u00ebshtja e madhe<\/em>&#8220;.<\/p>\n<p>Edhe n\u00ebse Martin dhe Russell kan\u00eb gabime rreth jet\u00ebs q\u00eb fillon n\u00eb shfryn e detit t\u00eb thell\u00eb, shum\u00eb elemente t\u00eb teoris\u00eb s\u00eb tyre jan\u00eb pothuajse me siguri t\u00eb sakta. Nj\u00ebra \u00ebsht\u00eb r\u00ebnd\u00ebsia e metaleve p\u00ebr lindjen e jet\u00ebs.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Kjo enzim\u00eb ka nj\u00eb jon metali\" src=\"http:\/\/fjala.info\/2018\/p04cl3xj.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Kjo enzim\u00eb ka nj\u00eb jon metali n\u00eb b\u00ebrtham\u00ebn e saj<\/em><br \/>\n(Credit: Laguna Design\/Science Photo Library)<\/p>\n<\/blockquote>\n<p>N\u00eb natyr\u00eb, shum\u00eb enzima kan\u00eb nj\u00eb atom metali n\u00eb b\u00ebrtham\u00ebn e tyre. Kjo \u00ebsht\u00eb shpesh pjesa &#8220;aktive&#8221; e enzim\u00ebs, me pjes\u00ebn tjet\u00ebr t\u00eb molekul\u00ebs, n\u00eb thelb nj\u00eb struktur\u00eb mb\u00ebshtet\u00ebse. Jeta e par\u00eb nuk mund t&#8217;i ket\u00eb pasur k\u00ebto enzima komplekse, k\u00ebshtu q\u00eb n\u00eb vend t\u00eb k\u00ebsaj, ajo ndoshta i p\u00ebrdorte metalet e &#8220;zhveshura&#8221; si katalizator\u00eb.<\/p>\n<blockquote><p><em>Jeta nuk mund t\u00eb ket\u00eb filluar n\u00eb det t\u00eb thell\u00eb<\/em><\/p><\/blockquote>\n<p>G\u00fcnter W\u00e4chtersh\u00e4user e b\u00ebri k\u00ebt\u00eb pik\u00eb kur ai sugjeroi se jeta \u00ebsht\u00eb formuar n\u00eb pirit t\u00eb hekurt. N\u00eb m\u00ebnyr\u00eb t\u00eb ngjashme, Russell thekson se uj\u00ebrat e shfrynjes hidrotermale jan\u00eb t\u00eb pasura me metale, t\u00eb cilat mund t\u00eb veprojn\u00eb si katalizator\u00eb &#8211; dhe studimi i Martinit p\u00ebr LUCA zbuloi shum\u00eb enzima t\u00eb bazuara n\u00eb hekur.<\/p>\n<p>N\u00eb drit\u00ebn e k\u00ebsaj, po thuhet se shum\u00eb nga reagimet kimike t\u00eb Sutherland-it mb\u00ebshteten n\u00eb bak\u00ebr (dhe, rast\u00ebsisht, n\u00eb squfur, q\u00eb W\u00e4chtersh\u00e4user gjithashtu e theksoi) dhe se ARN n\u00eb protocell\u00ebt e Szostak ka nevoj\u00eb p\u00ebr magnez.<\/p>\n<p>Mund t\u00eb jet\u00eb akoma, q\u00eb shfrynjet hidrotermale do t\u00eb jen\u00eb t\u00eb r\u00ebnd\u00ebsishme. &#8220;<em>N\u00ebse ju shikoni n\u00eb metabolizmin modern, i ka t\u00eb gjitha k\u00ebto gj\u00ebra me t\u00eb v\u00ebrtet\u00eb sugjestive si grupimet hekur-squfur<\/em>&#8220;, thot\u00eb Szostak. Kjo i p\u00ebrshtatet ides\u00eb se jeta filloi n\u00eb ose rreth nj\u00eb rryme, ku uji \u00ebsht\u00eb i pasur me hekur dhe squfur.<\/p>\n<p>Kjo do t\u00eb thot\u00eb, se Sutherland dhe Szostak jan\u00eb n\u00eb rrug\u00ebn e duhur, nj\u00eb aspekt i teoris\u00eb s\u00eb ndenj\u00ebseve \u00ebsht\u00eb padyshim i gabuar: <strong>jeta nuk mund t\u00eb ket\u00eb filluar n\u00eb det t\u00eb thell\u00eb<\/strong>.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Ndoshta jeta filloi n\u00eb nj\u00eb pellg vullkanik\" src=\"http:\/\/fjala.info\/2018\/p04cl38z.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Ndoshta jeta filloi n\u00eb nj\u00eb pellg vullkanik si ky n\u00eb Parkun Komb\u00ebtar t\u00eb Yellowstone, SHBA<\/em><br \/>\n(Credit: Cothron Photography\/Alamy)<\/p>\n<\/blockquote>\n<p>&#8220;<em>Kimia q\u00eb kemi zbuluar \u00ebsht\u00eb aq e varur nga UV [drita ultravjollc\u00eb]<\/em>,&#8221; thot\u00eb Sutherland. Burimi i vet\u00ebm i rrezatimit ultravjollc\u00eb \u00ebsht\u00eb Dielli, k\u00ebshtu q\u00eb reagimet e tij mund t\u00eb ndodhin vet\u00ebm n\u00eb vende me diell. &#8220;<em>Kjo e p\u00ebrjashton skenarin e detit t\u00eb thell\u00eb<\/em>.&#8221;<\/p>\n<blockquote><p><em>Ndoshta jeta filloi n\u00eb tok\u00eb, n\u00eb nj\u00eb pellg vullkanik<\/em><\/p><\/blockquote>\n<p>Szostak pajtohet q\u00eb deti i thell\u00eb nuk ishte \u00e7erdhe e jet\u00ebs. &#8220;<em>Gj\u00ebja m\u00eb e keqe \u00ebsht\u00eb se \u00ebsht\u00eb e izoluar nga kimia atmosferike, e cila \u00ebsht\u00eb burimi i materialeve t\u00eb nisjes s\u00eb energjis\u00eb s\u00eb lart\u00eb si cianidi<\/em>&#8220;.<\/p>\n<p>Por k\u00ebto probleme nuk i p\u00ebrjashtojn\u00eb shfryrjet hidrotermale krejt\u00ebsisht. Ndoshta shfryrjet ishin thjesht\u00eb n\u00eb uj\u00eb t\u00eb cek\u00ebt, ku drita e diellit dhe cianidi mund t\u00eb arrinin ato.<\/p>\n<p>Armen Mulkidjanian ka sugjeruar nj\u00eb alternativ\u00eb. Ndoshta jeta filloi n\u00eb tok\u00eb, n\u00eb nj\u00eb pellg vullkanik.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Ndoshta jeta filloi n\u00eb nj\u00eb det t\u00eb cek\u00ebt\" src=\"http:\/\/fjala.info\/2018\/p04cl2vh.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Ndoshta jeta filloi n\u00eb nj\u00eb det t\u00eb cek\u00ebt<\/em><br \/>\n(Credit: ArteSub\/Alamy)<\/p>\n<\/blockquote>\n<p>Mulkidjanian shikon p\u00ebrb\u00ebrjen kimike t\u00eb qelizave: n\u00eb m\u00ebnyr\u00eb t\u00eb ve\u00e7ant\u00eb, cilat kimikate ata lejojn\u00eb brenda dhe cilat i mbajn\u00eb jasht\u00eb. Rezulton se t\u00eb gjitha qelizat, pavar\u00ebsisht nga organizmi q\u00eb i p\u00ebrkasin, p\u00ebrmbajn\u00eb shum\u00eb fosfate, kalium dhe metale t\u00eb tjera &#8211; por v\u00ebshtir\u00eb se ka natrium.<\/p>\n<blockquote><p><em>Skenari im i preferuar p\u00ebr momentin do t\u00eb ishte nj\u00eb tip liqeni ose pellgu i cek\u00ebt n\u00eb sip\u00ebrfaqe<\/em><\/p><\/blockquote>\n<p>N\u00eb dit\u00ebt e sotme, qelizat e arrijn\u00eb k\u00ebt\u00eb duke pompuar gj\u00ebrat brenda dhe jasht\u00eb, por qelizat e para nuk mund ta b\u00ebjn\u00eb k\u00ebt\u00eb sepse nuk do t\u00eb kishin makineri t\u00eb nevojshme. Pra, Mulkidjanian sugjeroi q\u00eb qelizat e para t\u00eb formuara diku kishin pothuajse t\u00eb nj\u00ebjt\u00ebn p\u00ebrzierje kimikash si qelizat moderne.<\/p>\n<p>Kjo menj\u00ebher\u00eb eliminon oqeanin. Qelizat p\u00ebrmbajn\u00eb nivele shum\u00eb m\u00eb t\u00eb larta t\u00eb kaliumit dhe fosfatit, se sa mban oqeani, dhe shum\u00eb m\u00eb pak natrium.<\/p>\n<p>N\u00eb vend t\u00eb k\u00ebsaj, <a href=\"http:\/\/www.pnas.org\/content\/109\/14\/E821\" rel=\"noopener noreferrer\" target=\"_blank\">ajo tregon p\u00ebr pellgjet gjeotermike t\u00eb gjetura pran\u00eb vullkaneve aktive<\/a>. K\u00ebto pellgje kan\u00eb sakt\u00ebsisht koktej t\u00eb metaleve t\u00eb gjetura n\u00eb qeliza.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Burimet e nxehta - djepi i jet\u00ebs\" src=\"http:\/\/fjala.info\/2018\/p04cl4jb.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Burimet e nxehta mund t\u00eb ken\u00eb qen\u00eb djepi i jet\u00ebs<\/em><br \/>\n(Credit: Brocken Inaglory, CC by 3.0)<\/p>\n<\/blockquote>\n<p>Szostak \u00ebsht\u00eb nj\u00eb tifoz. &#8220;<em>Un\u00eb mendoj se skenari im i preferuar n\u00eb k\u00ebt\u00eb moment do t\u00eb ishte nj\u00eb tip liqeni ose pellgu i cek\u00ebt n\u00eb sip\u00ebrfaqe, n\u00eb nj\u00eb zon\u00eb gjeotermale-aktive<\/em>&#8220;, thot\u00eb ai. &#8220;<em>Ju keni shina hidrotermale, por jo si shfryrjet e detit t\u00eb thell\u00eb, m\u00eb shum\u00eb si tipi i shfryrjeve q\u00eb kemi n\u00eb zona vullkanike si Yellowstone<\/em>&#8220;.<\/p>\n<p><strong><em>Toka u godit nga meteorit\u00eb p\u00ebrgjat\u00eb gjysm\u00ebs s\u00eb par\u00eb t\u00eb ekzistenc\u00ebs s\u00eb saj<\/em><\/strong><\/p>\n<p>Kimia e Sutherlandit mund t\u00eb funksionoj\u00eb n\u00eb nj\u00eb vend t\u00eb till\u00eb. Burimet kan\u00eb kimikate t\u00eb duhura, niveli i ujit luhatet, k\u00ebshtu q\u00eb disa vende do t\u00eb thahen her\u00eb pas here dhe ka shum\u00eb rrezatim ultravjollc\u00eb nga Dielli.<\/p>\n<p>P\u00ebr m\u00eb tep\u00ebr, Szostak thot\u00eb se pellgjet do t\u00eb ishin t\u00eb p\u00ebrshtatshme p\u00ebr protocellet e tij.<\/p>\n<p>&#8220;<em>Protocell\u00ebt mund t\u00eb jen\u00eb relativisht t\u00eb ftohta n\u00eb pjes\u00ebn m\u00eb e madhe e koh\u00ebs, gj\u00eb q\u00eb \u00ebsht\u00eb e mir\u00eb p\u00ebr kopjimin e ARN-s\u00eb dhe p\u00ebr llojet e tjera t\u00eb metabolizmit t\u00eb thjesht\u00eb<\/em>&#8220;, thot\u00eb Szostak. &#8220;<em>Por \u00e7do her\u00eb pas here ata nxehen shkurtimisht, dhe kjo ndihmon q\u00eb fillesat e ARN t\u00eb dalin gati p\u00ebr raundin tjet\u00ebr t\u00eb p\u00ebrs\u00ebritur<\/em>&#8220;. Gjithashtu do t\u00eb kishte rryma, t\u00eb nxitura nga rrjedhat e ujit t\u00eb nxeht\u00eb, t\u00eb cilat mund t\u00eb ndihmonin ndarjen e protocell\u00ebve.<\/p>\n<p>Duke u mb\u00ebshtetur n\u00eb shum\u00eb nga argumentet e nj\u00ebjta, Sutherland ka paraqitur nj\u00eb mund\u00ebsi t\u00eb tret\u00eb: <strong>nj\u00eb zon\u00eb ndikim meteoriti<\/strong>.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Ndikimi nga nj\u00eb krater meteori\" src=\"http:\/\/fjala.info\/2018\/p04cl2l4.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Ndikimi nga nj\u00eb krater meteori mund t\u00eb ket\u00eb qen\u00eb fillimi i jet\u00ebs<\/em><br \/>\n(Credit: Detlev van Ravenswaay\/Science Photo Library)<\/p>\n<\/blockquote>\n<p>Toka \u00ebsht\u00eb goditur nga meteorite p\u00ebrgjat\u00eb gjysm\u00ebshekullit t\u00eb par\u00eb t\u00eb ekzistenc\u00ebs s\u00eb saj <a href=\"http:\/\/www.bbc.com\/earth\/story\/20160415-what-really-happened-when-the-dino-killer-asteroid-struck\" rel=\"noopener noreferrer\" target=\"_blank\">dhe q\u00eb at\u00ebher\u00eb \u00ebsht\u00eb goditur ndonj\u00ebher\u00eb<\/a>. Nj\u00eb ndikim i denj\u00eb i madh do t\u00eb krijonte nj\u00eb struktur\u00eb mjaft t\u00eb ngjashme me pellgjet e Mulkidjanianit.<\/p>\n<p>S\u00eb pari, meteorit\u00eb jan\u00eb kryesisht prej metali. Zonat e ndikimit kan\u00eb tendenc\u00eb t\u00eb jen\u00eb t\u00eb pasura me metale t\u00eb dobishme si hekuri, si dhe squfuri. Dhe n\u00eb thelb, ndikimet meteorite shkrijn\u00eb koren e Tok\u00ebs, duke \u00e7uar n\u00eb aktivitet gjeotermik dhe uj\u00eb t\u00eb nxeht\u00eb.<\/p>\n<blockquote><p><em>N\u00ebse del se nj\u00ebrit prej skenar\u00ebve i mungon nj\u00eb element kimik ky\u00e7, ose p\u00ebrmban di\u00e7ka q\u00eb shkat\u00ebrron protocellet, ato do t\u00eb p\u00ebrjashtohen<\/em><\/p><\/blockquote>\n<p>Sutherland imagjinoi lumenj dhe p\u00ebrrenj t\u00eb vegj\u00ebl, q\u00eb rrjedhin posht\u00eb shpateve t\u00eb nj\u00eb krateri t\u00eb ndikimit, elementeve kimike t\u00eb bazuara n\u00eb cianur nga shk\u00ebmbinjt\u00eb, nd\u00ebrsa rrezatimi ultravjollc\u00eb derdhet nga posht\u00eb &#8211; lart. \u00c7do lum\u00eb do t\u00eb kishte nj\u00eb p\u00ebrzierje paksa t\u00eb ndryshme t\u00eb kimikateve, k\u00ebshtu q\u00eb do t\u00eb ndodhnin reagime t\u00eb ndryshme dhe do t\u00eb prodhohej nj\u00eb mori e t\u00ebr\u00eb e kimikateve organike.<\/p>\n<p>S\u00eb fundi rrjedhat do t\u00eb rrjedhin n\u00eb nj\u00eb pellg vullkanik n\u00eb fund t\u00eb kraterit. Mund t\u00eb kishte qen\u00eb nj\u00eb pellg i till\u00eb, ku t\u00eb gjitha pjes\u00ebt u bashkuan dhe u formuan protocell\u00ebt e par\u00eb.<\/p>\n<p>&#8220;<em>Ky \u00ebsht\u00eb nj\u00eb skenar shum\u00eb i ve\u00e7ant\u00eb<\/em>,&#8221; thot\u00eb Sutherland. Por ai e zgjodhi at\u00eb n\u00eb baz\u00eb t\u00eb reaksioneve kimike, q\u00eb kishte gjetur. &#8220;<em>\u00cbsht\u00eb e vetmja q\u00eb mund t\u00eb mendojm\u00eb se \u00ebsht\u00eb n\u00eb p\u00ebrputhje me kimin\u00eb<\/em>&#8220;.<\/p>\n<p>Szostak nuk \u00ebsht\u00eb i sigurt n\u00eb asnj\u00eb m\u00ebnyr\u00eb, por ai pajtohet, q\u00eb ideja e Sutherland meriton v\u00ebmendje t\u00eb kujdesshme. &#8220;<em>Un\u00eb mendoj se skenari i ndikimit \u00ebsht\u00eb i k\u00ebndsh\u00ebm, mendoj se ideja e sistemeve vullkanike mund t\u00eb funksionoj\u00eb. Ka disa argumente n\u00eb favor t\u00eb secilit<\/em>&#8220;.<\/p>\n<p>Tani p\u00ebr tani, debati duket i vendosur t\u00eb gj\u00ebmoj\u00eb. Por nuk do t\u00eb vendoset p\u00ebr nj\u00eb trillim. Vendimi do t\u00eb nxitet nga kimia dhe protocellet. N\u00ebse rezulton se n\u00eb nj\u00ebrin nga skenar\u00ebt mungon nj\u00eb element kimik ky\u00e7, ose p\u00ebrmban di\u00e7ka q\u00eb shkat\u00ebrron protocellet, do t\u00eb p\u00ebrjashtohet.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Shfryrjet n\u00eb East Scotia Ridge \" src=\"http:\/\/fjala.info\/2018\/p04cl96z.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Shfryrjet n\u00eb East Scotia Ridge (Kurrizi n\u00eb lindje t\u00eb Skocis\u00eb)<\/em><br \/>\n(Credit: A. D. Rogers et al, PLoS Biology, CC by 2.5)<\/p>\n<\/blockquote>\n<p>Kjo do t\u00eb thot\u00eb q\u00eb, p\u00ebr her\u00eb t\u00eb par\u00eb n\u00eb histori, kemi fillimet e nj\u00eb shpjegimi gjith\u00ebp\u00ebrfshir\u00ebs p\u00ebr m\u00ebnyr\u00ebn se si filloi jeta.<\/p>\n<p>&#8220;<em>Gj\u00ebrat po duken shum\u00eb m\u00eb t\u00eb arritshme<\/em>&#8220;, thot\u00eb Sutherland.<\/p>\n<blockquote><p><em>M\u00eb e mira q\u00eb mund t\u00eb b\u00ebjm\u00eb ndonj\u00ebher\u00eb \u00ebsht\u00eb t\u00eb hartojm\u00eb nj\u00eb histori q\u00eb \u00ebsht\u00eb n\u00eb p\u00ebrputhje me t\u00eb gjitha provat<\/em><\/p><\/blockquote>\n<p>Deri m\u00eb tani, qasja &#8220;\u00e7do gj\u00eb &#8211; p\u00ebrnj\u00ebher\u00eb&#8221; e Szostak dhe Sutherland ofron vet\u00ebm nj\u00eb tregim t\u00eb skicuar. Por ato hapa q\u00eb jan\u00eb p\u00ebrpunuar mb\u00ebshteten nga dekada eksperimentesh.<\/p>\n<p>Ideja gjithashtu bazohet n\u00eb \u00e7do qasje ndaj origjin\u00ebs s\u00eb jet\u00ebs. Ajo p\u00ebrpiqet t\u00eb shfryt\u00ebzoj\u00eb t\u00eb gjitha pikat e tyre t\u00eb mira, nd\u00ebrsa n\u00eb t\u00eb nj\u00ebjt\u00ebn koh\u00eb t\u00eb zgjidh\u00eb t\u00eb gjitha problemet e tyre. P\u00ebr shembull, nuk p\u00ebrpiqet aq shum\u00eb p\u00ebr t\u00eb hedhur posht\u00eb idet\u00eb e Russell p\u00ebr shfryrjet hidrotermale, por p\u00ebr t&#8217;i p\u00ebrfshir\u00eb element\u00ebt e tyre m\u00eb t\u00eb mir\u00eb.<\/p>\n<p>Nuk mund ta dim\u00eb me siguri, se \u00e7far\u00eb ndodhi kat\u00ebr miliard vjet m\u00eb par\u00eb. &#8220;<em>Edhe sikur t\u00eb b\u00ebsh nj\u00eb reaktor dhe t\u00eb dal\u00ebsh nga <strong>E. coli<\/strong> n\u00eb an\u00ebn tjet\u00ebr &#8230; ende nuk mund t\u00eb provosh, se ne u ngrit\u00ebm n\u00eb at\u00eb m\u00ebnyr\u00eb<\/em>&#8220;, thot\u00eb Martin.<\/p>\n<p>M\u00eb e mira q\u00eb mund t\u00eb b\u00ebjm\u00eb ndonj\u00ebher\u00eb \u00ebsht\u00eb t\u00eb hartojm\u00eb nj\u00eb histori, q\u00eb \u00ebsht\u00eb n\u00eb p\u00ebrputhje me t\u00eb gjitha d\u00ebshmit\u00eb: me eksperimente n\u00eb kimi, me at\u00eb q\u00eb dim\u00eb p\u00ebr Tok\u00ebn e hershme dhe me at\u00eb q\u00eb zbulon biologjia, p\u00ebr format m\u00eb t\u00eb vjetra t\u00eb jet\u00ebs. S\u00eb fundi, pas nj\u00eb shekulli t\u00eb p\u00ebrpjekjeve t\u00eb rr\u00ebnjosura, kjo histori po shfaqet m\u00eb e qart\u00eb.<\/p>\n<blockquote>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" title=\"Si e shohim ne bot\u00ebn\" src=\"http:\/\/fjala.info\/2018\/p04cl437.jpg\" alt=\"\" width=\"600\" border=\"0\" \/><em>Zbulimet tona ndryshojn\u00eb pik\u00ebpamjen, se si e shohim bot\u00ebn<\/em><br \/>\n(Credit: Nasa\/ESA\/Samantha Cristoforetti)<\/p>\n<\/blockquote>\n<p>Kjo do t\u00eb thot\u00eb q\u00eb po i afrohemi nj\u00eb ndarjeje t\u00eb madhe n\u00eb historin\u00eb njer\u00ebzore: ndarjen mes atyre q\u00eb e njohin historin\u00eb e fillimit t\u00eb jet\u00ebs dhe atyre q\u00eb nuk mund\u00ebn kurr\u00eb.<\/p>\n<blockquote><p><em>Disa nga njer\u00ebzit e gjall\u00eb sot do t\u00eb b\u00ebhen t\u00eb par\u00ebt n\u00eb histori, t\u00eb cil\u00ebt me sinqeritet mund t\u00eb thon\u00eb se e din\u00eb se nga kan\u00eb ardhur<\/em><\/p><\/blockquote>\n<p>\u00c7do person i vet\u00ebm q\u00eb vdiq para se Darvini t\u00eb botonte Origjina e Specieve n\u00eb vitin 1859, nuk ishte n\u00eb dijeni t\u00eb origjin\u00ebs s\u00eb njer\u00ebzimit, sepse ata nuk dinin asgj\u00eb p\u00ebr evolucionin. Por gjithkush i gjall\u00eb tani, duke p\u00ebrjashtuar grupe t\u00eb izoluara, mund t\u00eb njoh\u00eb t\u00eb v\u00ebrtet\u00ebn p\u00ebr lidhjen ton\u00eb me kafsh\u00ebt e tjera.<\/p>\n<p>Ngjash\u00ebm me k\u00ebt\u00eb, t\u00eb gjith\u00eb ata q\u00eb kan\u00eb lindur, pasi Yuri Gagarin u rrotullua n\u00eb orbit\u00ebn e Tok\u00ebs n\u00eb vitin 1961, kan\u00eb jetuar n\u00eb nj\u00eb shoq\u00ebri q\u00eb mund t\u00eb udh\u00ebtoj\u00eb p\u00ebr n\u00eb bot\u00eb t\u00eb tjera. Edhe n\u00ebse ata nuk shkojm\u00eb kurr\u00eb, udh\u00ebtimi n\u00eb hap\u00ebsir\u00eb \u200b\u200b\u00ebsht\u00eb nj\u00eb realitet.<\/p>\n<p>K\u00ebto fakte ndryshojn\u00eb bot\u00ebkuptimin ton\u00eb n\u00eb m\u00ebnyra delikate. Sigurisht, ato na b\u00ebjn\u00eb m\u00eb t\u00eb men\u00e7ur. Evolucioni na m\u00ebson t\u00eb vler\u00ebsojm\u00eb \u00e7do gj\u00eb tjet\u00ebr t\u00eb gjall\u00eb n\u00eb tok\u00eb, sepse ata jan\u00eb kush\u00ebrinjt\u00eb tan\u00eb. Udh\u00ebtimi hap\u00ebsinor <a href=\"http:\/\/www.bbc.com\/earth\/story\/20151109-take-a-trip-around-the-pale-blue-dot-we-all-call-home\" target=\"_blank\" rel=\"noopener noreferrer\">na lejon t\u00eb shohim bot\u00ebn ton\u00eb nga nj\u00eb distanc\u00eb<\/a>, duke zbuluar se sa e ve\u00e7ant\u00eb dhe e brisht\u00eb \u00ebsht\u00eb ajo.<\/p>\n<p>Disa nga njer\u00ebzit e gjall\u00eb sot do t\u00eb b\u00ebhen t\u00eb par\u00ebt n\u00eb histori, t\u00eb cil\u00ebt me sinqeritet mund t\u00eb thon\u00eb se e din\u00eb se nga kan\u00eb ardhur. Ata do t\u00eb din\u00eb se \u00e7far\u00eb ishte paraardh\u00ebsi i tyre i fundit dhe ku jetonte.<\/p>\n<p>Kjo njohuri do t\u00eb na ndryshoj\u00eb. N\u00eb nj\u00eb shkall\u00eb t\u00eb past\u00ebr shkencore, ajo do t\u00eb na tregoj\u00eb se si mund t\u00eb jet\u00eb jeta n\u00eb Univers, dhe ku ta k\u00ebrkojn\u00eb. Dhe kjo do t\u00eb na tregoj\u00eb di\u00e7ka rreth natyr\u00ebs thelb\u00ebsore t\u00eb jet\u00ebs. Por p\u00ebrtej k\u00ebsaj, ende nuk mund ta dim\u00eb men\u00e7urin\u00eb, q\u00eb do t\u00eb zbuloj\u00eb origjina e jet\u00ebs.<\/p>\n<hr \/>\n<p><em>Lexo shkrimin e plot\u00eb n\u00eb anglisht nga BBC:<\/em><br \/>\n<a href=\"http:\/\/www.bbc.com\/earth\/story\/20161026-the-secret-of-how-life-on-earth-began\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/www.bbc.com\/earth\/story\/20161026-the-secret-of-how-life-on-earth-began<\/a><\/p>\n<blockquote><p><strong>Sh\u00ebnime<\/strong>:<\/p>\n<p>1. <strong>coacervates<\/strong> &#8211; nj\u00eb gjendje e l\u00ebngshme viskoze (xhelatinoze), e pasur me colloide (p\u00ebrzierje), q\u00eb mund t\u00eb ndahet nga nj\u00eb zgjidhje koloidale me shtimin e nj\u00eb komponenti t\u00eb tret\u00eb.<\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>Nga\u00a0Michael Marshall, 31 tetor 2016 P\u00ebrktheu dhe p\u00ebrgatiti n\u00eb shqip, Arben \u00c7okaj Kjo histori \u00ebsht\u00eb pjes\u00eb e list\u00ebs s\u00eb BBC p\u00ebr Tok\u00ebn &#8220;M\u00eb e mira p\u00ebr\u00a02016&#8243;, rezultati m\u00eb i madh i vitit. Shfletoni list\u00ebn e plot\u00eb. (n\u00eb anglisht) Charles Blomfield &#8220;Tarracat e bardha, Rotomahana&#8221; (1897) (Credit: PAINTING\/Alamy Stock Photo) Si filloi jeta n\u00eb tok\u00eb? Nuk [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":22797,"comment_status":"open","ping_status":"closed","sticky":true,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,4,38,9,36],"tags":[],"class_list":["post-22794","post","type-post","status-publish","format-standard","has-post-thumbnail","category-artikuj","category-histori","category-kuriozitete","category-ne-plan-te-pare","category-shkence"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>SI KA FILLUAR JETA N\u00cb TOK\u00cb? - nj\u00eb artikull i BBC b\u00ebn sqarimin shkencor - FJALA e LIR\u00cb<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/jehonashqiptare.al\/fjala\/si-ka-filluar-jeta-ne-toke\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"SI KA FILLUAR JETA N\u00cb TOK\u00cb? - nj\u00eb artikull i BBC b\u00ebn sqarimin shkencor - FJALA e LIR\u00cb\" \/>\n<meta property=\"og:description\" content=\"Nga\u00a0Michael Marshall, 31 tetor 2016 P\u00ebrktheu dhe p\u00ebrgatiti n\u00eb shqip, Arben \u00c7okaj Kjo histori \u00ebsht\u00eb pjes\u00eb e list\u00ebs s\u00eb BBC p\u00ebr Tok\u00ebn &#8220;M\u00eb e mira p\u00ebr\u00a02016&#8243;, rezultati m\u00eb i madh i vitit. 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- nj\u00eb artikull i BBC b\u00ebn sqarimin shkencor - FJALA e LIR\u00cb","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/jehonashqiptare.al\/fjala\/si-ka-filluar-jeta-ne-toke\/","og_locale":"en_US","og_type":"article","og_title":"SI KA FILLUAR JETA N\u00cb TOK\u00cb? - nj\u00eb artikull i BBC b\u00ebn sqarimin shkencor - FJALA e LIR\u00cb","og_description":"Nga\u00a0Michael Marshall, 31 tetor 2016 P\u00ebrktheu dhe p\u00ebrgatiti n\u00eb shqip, Arben \u00c7okaj Kjo histori \u00ebsht\u00eb pjes\u00eb e list\u00ebs s\u00eb BBC p\u00ebr Tok\u00ebn &#8220;M\u00eb e mira p\u00ebr\u00a02016&#8243;, rezultati m\u00eb i madh i vitit. Shfletoni list\u00ebn e plot\u00eb. (n\u00eb anglisht) Charles Blomfield &#8220;Tarracat e bardha, Rotomahana&#8221; (1897) (Credit: PAINTING\/Alamy Stock Photo) Si filloi jeta n\u00eb tok\u00eb? Nuk [&hellip;]","og_url":"https:\/\/jehonashqiptare.al\/fjala\/si-ka-filluar-jeta-ne-toke\/","og_site_name":"FJALA e LIR\u00cb","article_publisher":"https:\/\/facebook.com\/fjala.info\/","article_author":"https:\/\/facebook.com\/shkoder.net\/","article_published_time":"2018-01-26T00:31:33+00:00","article_modified_time":"2020-04-08T13:54:05+00:00","og_image":[{"width":600,"height":366,"url":"https:\/\/jehonashqiptare.al\/fjala\/wp-content\/uploads\/2018\/01\/p04cl3qr.jpg","type":"image\/jpeg"}],"author":"admin","twitter_card":"summary_large_image","twitter_creator":"@https:\/\/twitter.com\/acokaj","twitter_site":"@acokaj","twitter_misc":{"Written by":"admin","Est. reading time":"98 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/jehonashqiptare.al\/fjala\/si-ka-filluar-jeta-ne-toke\/#article","isPartOf":{"@id":"https:\/\/jehonashqiptare.al\/fjala\/si-ka-filluar-jeta-ne-toke\/"},"author":{"name":"admin","@id":"https:\/\/jehonashqiptare.al\/fjala\/#\/schema\/person\/9c9fccf4f6449d25e258607d9b4275cb"},"headline":"SI KA FILLUAR JETA N\u00cb TOK\u00cb? 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