{"id":3449,"date":"2016-06-03T08:21:34","date_gmt":"2016-06-03T07:21:34","guid":{"rendered":"http:\/\/www.fjala.info\/?p=3449"},"modified":"2021-03-10T00:20:43","modified_gmt":"2021-03-09T23:20:43","slug":"shkencetaret-kane-gjetur-zgjidhjen-qe-ndalon-dhe-kthen-mbrapa-procesin-e-plakjes","status":"publish","type":"post","link":"https:\/\/jehonashqiptare.al\/fjala\/shkencetaret-kane-gjetur-zgjidhjen-qe-ndalon-dhe-kthen-mbrapa-procesin-e-plakjes\/","title":{"rendered":"Shkenc\u00ebtaret kan\u00eb gjetur zgjidhjen q\u00eb ndalon dhe kthen mbrapa procesin e plakjes"},"content":{"rendered":"

Dita e \u201ct\u00eb rinj p\u00ebrgjithmon\u00eb\u201d \u00ebsht\u00eb af\u00ebr<\/strong>.<\/p>\n

WeSpeakScience.com<\/a>, 2 qershor 2015<\/em><\/p>\n

Plakja \u00ebsht\u00eb nj\u00eb proces i natyrsh\u00ebm, edhe pse shumica e njer\u00ebzve \u201ckan\u00eb frik\u00eb\u201c nga ajo.<\/p>\n

Nj\u00eb citat thot\u00eb se metoda e vetme p\u00ebr t\u00eb liruar veten nga plakja \u00ebsht\u00eb duke e ri-interpretuar trupin tuaj dhe duke ngushtuar lidhjen midis besimit dhe biologjis\u00eb (nj\u00eb th\u00ebnie nga Deepak Chopra)<\/p>\n

Studimi i ri tregon se kjo nuk \u00ebsht\u00eb e vetmja m\u00ebnyr\u00eb p\u00ebr t\u00eb ndaluar plakjen. Duket se shkenc\u00ebtari tani kan\u00eb \u00e7el\u00ebsin e rinis\u00eb s\u00eb p\u00ebrjetshme.<\/p>\n

Procesi i plakjes n\u00eb vetvete ka t\u00ebrhequr gjithnj\u00eb v\u00ebmendjen e shkenc\u00ebtar\u00ebve dhe teori t\u00eb ndryshme jan\u00eb botuar, por ky studim i ri japonez duket t\u00eb jet\u00eb di\u00e7ka me t\u00eb v\u00ebrtet\u00eb e shenjt\u00eb n\u00eb Mjek\u00ebsi (p\u00ebr arsye se eksperimenti \u00ebsht\u00eb b\u00ebr\u00eb n\u00eb qeliza njer\u00ebzore). M\u00eb par\u00eb, n\u00ebntor 2010, Universiteti i Harvardit publikoi nj\u00eb studim n\u00eb revist\u00ebn \u201cNature\u201d q\u00eb tregon ndalimin e procesit t\u00eb plakjes n\u00eb minj. Shkenc\u00ebtar\u00ebt pretenduan t\u00eb jen\u00eb nj\u00eb hap m\u00eb af\u00ebr p\u00ebr t\u00eb kthyer mbrapsht procesin e plakjes pas rinovimit t\u00eb organeve n\u00eb minj t\u00eb moshuar.<\/p>\n

Me sa duket, ekipi japonez i Universitetit Tsukuba, n\u00ebn udh\u00ebheqjen e profesor Hayashi e b\u00ebri k\u00ebt\u00eb hap dhe v\u00ebrtetoi se plakja e njeriut mund t\u00eb vonohet apo edhe t\u00eb kthehet mbrapsht, t\u00eb pakt\u00ebn n\u00eb nivelin m\u00eb themelor t\u00eb linjave t\u00eb qelizave njer\u00ebzore. Fjala ky\u00e7e e \u00e7do studimi t\u00eb plakjes jan\u00eb me siguri mitokondrit\u00eb, t\u00eb ashtuquajturat centrale elektrike t\u00eb qelizave pasi ato prodhojn\u00eb energji gjat\u00eb nj\u00eb procesi t\u00eb quajtur frym\u00ebmarrje qelizore.<\/p>\n

Duke gjetur se rregullimi i dy gjeneve \u00ebsht\u00eb i lidhur me m\u00ebnyr\u00ebn se si ne plakemi, ky studim i ri sfidoi teorin\u00eb m\u00eb t\u00eb populluar t\u00eb plakjes \u2013 \u201cteorin\u00eb mitokondriale e plakjes\u201d.<\/p>\n

Sipas k\u00ebsaj teorie popullore (\u201cTeoria mitokondriale e plakjes\u201c) arsyeja e plakjes \u00ebsht\u00eb defekti n\u00eb qelizat mitokondriale, p\u00ebr shkak t\u00eb mutacionit t\u00eb akumuluar n\u00eb AND-n\u00eb e tyre.<\/p>\n

Universiteti Tsukuba provoi se defektet nuk jan\u00eb p\u00ebr shkak t\u00eb mutacioneve n\u00eb ADN, por q\u00eb faktor\u00ebt e jasht\u00ebm mund t\u2019i shkaktojn\u00eb ato. Ata e pan\u00eb se si mitokondrit\u00eb ishin duke punuar n\u00eb linjat e qelizave q\u00eb rrjedhin nga t\u00eb rinjt\u00eb, dhe krahasuar ato me linja qelizore q\u00eb rrjedhin nga njer\u00ebz t\u00eb moshuar. Ajo q\u00eb ata gjet\u00ebn ishte interesante. Nuk kishte dallime t\u00eb dukshme n\u00eb numrin e mutacioneve n\u00eb ADN-n\u00eb mitokondriale mes qelizave t\u00eb vjetra dhe atyre t\u00eb reja.<\/p>\n

Ky zbulim i drejtoi shkenc\u00ebtar\u00ebt p\u00ebr t\u00eb studiuar nj\u00eb form\u00eb tjet\u00ebr t\u00eb rregullimit gjenetik, form\u00ebn epigjenetike, faktor\u00ebt e s\u00eb cil\u00ebs (t\u00eb tilla si shtimin e proteinave t\u00eb caktuara n\u00eb ADN-n\u00eb mitokondriale) mund t\u00eb krijojn\u00eb defekte q\u00eb shkaktojn\u00eb shenjat e plakjes. N\u00eb k\u00ebt\u00eb m\u00ebnyr\u00eb \u2013 propozuan studiuesit \u2013 at\u00ebher\u00eb \u201ckthimi\u201d i linjave qelizore n\u00eb qeliza burimore do t\u00eb korrigjoj\u00eb dhe do t\u00eb fshij\u00eb k\u00ebto faktor\u00eb epigjenetike. Kur ata e testuan k\u00ebt\u00eb me linja qelizore nga t\u00eb moshuarit, kjo \u00ebsht\u00eb pik\u00ebrisht ajo q\u00eb ata gjet\u00ebn. N\u00eb m\u00ebnyr\u00eb, ajo dukej se kthente qelizat \u201ce vjetra\u201d n\u00eb ato \u201ct\u00eb reja\u201d.<\/p>\n

Shkenc\u00ebtar\u00ebt k\u00ebrkuar p\u00ebr gjene, q\u00eb lidhen me defekte mitokondriale, t\u00eb cilat mund t\u00eb kontrollohen epigenetikisht. CGAT dhe SHMT2 jan\u00eb gjenet q\u00eb ata gjenden. K\u00ebto gjene kontrollojn\u00eb prodhimin e GLICINE-s, nj\u00eb aminoacid i ve\u00e7ant\u00eb. Shkenc\u00ebtaret lyen me glicin\u00eb linj\u00ebn qeliz\u00eb t\u00eb marra nga nj\u00eb 97 vje\u00e7ar p\u00ebr dhjet\u00eb dit\u00eb dhe pas dhjet\u00eb dit\u00ebsh ata v\u00ebrejt\u00ebn se glicina restauroi aft\u00ebsin\u00eb e mitokondrive p\u00ebr t\u00eb prodhuar energji dhe p\u00ebrmbysi disa defekte lidhur me mosh\u00ebn. Kjo sugjeron se trajtimi me glicin\u00eb mund t\u00eb ndryshoj\u00eb defektet e lidhura me mosh\u00ebn n\u00eb linja qelizore t\u00eb njeriut.<\/p>\n

Mbeten p\u00ebr t\u2019u b\u00ebr\u00eb analiza t\u00eb m\u00ebtejshme p\u00ebr k\u00ebt\u00eb teori, por ajo hedh drit\u00eb mbi t\u00eb ardhmen.<\/p>\n

Ku i dihet, ndoshta nj\u00eb dit\u00eb disa prej nesh do t\u00eb mund t\u00eb ken\u00eb mund\u00ebsin\u00eb q\u00eb t\u00eb mos e \u201cprovojn\u00eb\u201d procesin e natyrsh\u00ebm t\u00eb plakjes duke mbetur p\u00ebrgjithmon\u00eb t\u00eb rinj. Edhe pse kjo gj\u00eb \u00ebsht\u00eb pak e frikshme, vet\u00ebm duke menduar se ku t\u00eb gjith\u00eb ata njer\u00ebz q\u00eb do t\u00eb jetonin p\u00ebrgjithmon\u00eb t\u00eb rinj do t\u00eb q\u00ebndrojn\u00eb.<\/p>\n

REFERENCAT<\/strong>:<\/p>\n

http:\/\/www.iflscience.com\/health-and-medicine\/scientists-reverse-aging-human-cells-line
\nhttp:\/\/www.sciencedaily.com\/releases\/2015\/05\/150526085138.htm
\nhttp:\/\/www.gizmag.com\/reversal-of-aging-human-cell-lines\/37721\/
\nhttp:\/\/www.gmanetwork.com\/news\/story\/494634\/scitech\/science\/fountain-of-youth-scientists-find-way-to-reverse-aging-in-human-cells<\/p>\n

Anti-Aging: Japanese Scientists Tweak Genes To Reverse Aging Of Human Cells<\/a><\/p><\/blockquote>\n