{"id":37524,"date":"2019-01-25T11:17:01","date_gmt":"2019-01-25T10:17:01","guid":{"rendered":"http:\/\/www.fjala.info\/?p=37524"},"modified":"2019-01-25T11:35:41","modified_gmt":"2019-01-25T10:35:41","slug":"te-rejat-e-fundit-rreth-zbulimeve-shkencore-ne-fushen-e-autizmit","status":"publish","type":"post","link":"https:\/\/jehonashqiptare.al\/fjala\/te-rejat-e-fundit-rreth-zbulimeve-shkencore-ne-fushen-e-autizmit\/","title":{"rendered":"T\u00eb rejat e fundit rreth zbulimeve shkencore n\u00eb fush\u00ebn e AUTIZMIT"},"content":{"rendered":"

(Publikuar nga Radio Canada dit\u00ebn e premte, m\u00eb 18 janar 2019<\/em>)<\/p>\n

Qelizat staminale, p\u00ebr t\u00eb kuptuar zhvillimin e autizmit.<\/em><\/p><\/blockquote>\n

Sipas nj\u00eb studimi t\u00eb fundit, sistemi nervor i njer\u00ebzve me spektrin e autizmit zhvillohet me nj\u00eb rit\u00ebm m\u00eb t\u00eb shpejt\u00eb.<\/p>\n

Autori : Renaud Manuguerra-Gagn\u00e9<\/strong>
\nP\u00ebrkthyer nga Edlira Dedja<\/strong><\/p>\n

Duke p\u00ebrdorur nj\u00eb lloj t\u00eb ve\u00e7ant\u00eb qelizash staminale (burimore), disa shkenc\u00ebtar\u00eb kan\u00eb arritur t\u00eb v\u00ebzhgojn\u00eb se n\u00eb disa raste, neuronet e njer\u00ebzve me autiz\u00ebm zhvillohen dhe rriten me nj\u00eb rit\u00ebm t\u00eb p\u00ebrshpejtuar. Ky zbulim mund t\u00eb ofroj\u00eb mjete t\u00eb reja diagnostike dhe objektiva t\u00eb reja terapeutike.<\/p>\n

Autizmi \u00ebsht\u00eb nj\u00eb \u00e7rregullim i zhvillimit neurologjik dhe jasht\u00ebzakonisht i v\u00ebshtir\u00eb p\u00ebr t’u studiuar. Ai shfaqet n\u00eb forma t\u00eb ndryshme dhe njer\u00ebzit e p\u00ebrfshir\u00eb n\u00eb k\u00ebt\u00eb spekt\u00ebr nuk kan\u00eb gjithnj\u00eb t\u00eb nj\u00ebjtat simptoma.<\/p>\n

\"\"<\/p>\n

Nga ana tjet\u00ebr, edhe pse disa studime hedhin drit\u00eb mbi nj\u00eb tepric\u00eb transmetuesish midis neuroneve (qelizave nervore) ose mbi disa gene q\u00eb mund t\u00eb luajn\u00eb nj\u00eb rol t\u00eb r\u00ebnd\u00ebsish\u00ebm n\u00eb k\u00ebt\u00eb drejtim, ende nuk dihet se n\u00eb cil\u00ebn etap\u00eb t\u00eb zhvillimit krijohen kushtet e favorshme q\u00eb \u00e7ojn\u00eb n\u00eb autiz\u00ebm.<\/p>\n

Disa simptoma mund t\u00eb fillojn\u00eb t\u00eb shfaqen rreth mosh\u00ebs nj\u00eb deri n\u00eb dy vje\u00e7 e p\u00ebr k\u00ebt\u00eb arsye, \u00e7do studim q\u00eb k\u00ebrkon t\u00eb p\u00ebrcaktoj\u00eb shkaqet e k\u00ebtij \u00e7regullimi duhet b\u00ebr\u00eb n\u00eb m\u00ebnyr\u00eb retrospektive, gj\u00eb q\u00eb e komplikon edhe m\u00eb shum\u00eb detyr\u00ebn e k\u00ebrkuesit.<\/p>\n

Disa shkenc\u00ebtar\u00eb t\u00eb hulumtimeve biomjek\u00ebsore kan\u00eb arritur t\u00eb shohin se disa prej k\u00ebtyre dallimeve shfaqen n\u00eb fazat e hershme t\u00eb zhvillimit t\u00eb trurit, pik\u00ebrisht gjat\u00eb formimit t\u00eb neuroneve.<\/p>\n

Duke rikrijuar disa prej etapave themelore t\u00eb formimit t\u00eb neuroneve n\u00eb laborator, k\u00ebta studiues mund\u00ebsuan ndjekjen n\u00eb koh\u00eb reale t\u00eb zhvillimit t\u00eb neuroneve, duke dalluar n\u00eb k\u00ebt\u00eb m\u00ebnyr\u00eb, detaje q\u00eb deri tashm\u00eb kishin mbetur t\u00eb paarritshme.<\/p>\n

Zmadhim n\u00ebp\u00ebrmjet mikroskopit<\/strong><\/p>\n

Teknika e p\u00ebrdorur nga hulumtuesit n\u00eb v\u00ebzhgimet e tyre k\u00ebrkon t\u00eb ashtuquajturat qeliza staminale pluripotente t\u00eb induktuara (iPSCs).<\/p>\n

Kjo teknik\u00eb, e zhvilluar p\u00ebr her\u00eb t\u00eb par\u00eb n\u00eb vitin 2006, mund\u00ebson transformimin e \u00e7do lloj qelize t\u00eb trupit n\u00eb nj\u00eb qeliz\u00eb staminale (burimore), q\u00eb \u00ebsht\u00eb materiali baz\u00eb p\u00ebr fabrikimin e t\u00eb gjitha indeve dhe organeve.<\/p>\n

Duke riaktivizuar gene t\u00eb caktuara q\u00eb lidhen me zhvillimin embrional n\u00eb nj\u00eb qeliz\u00eb t\u00eb l\u00ebkur\u00ebs, kjo e fundit do t\u00eb mbetet e pazhvilluar dhe do t\u00eb gjej\u00eb mund\u00ebsin\u00eb e diferencimit nga \u00e7do lloj indi tjet\u00ebr trupor.<\/p>\n

E vetmja gj\u00eb q\u00eb u mbetet m\u00eb pas studiuesve \u00ebsht\u00eb q\u00eb ti ndjekin k\u00ebto iPSC n\u00eb m\u00ebnyr\u00eb t\u00eb till\u00eb sa t\u00eb b\u00ebhen neurone q\u00eb nd\u00ebrlidhen me nj\u00ebra-tjetr\u00ebn n\u00eb nj\u00eb struktur\u00eb tredimensionale n\u00eb miniatur\u00eb. Vet\u00ebm n\u00eb k\u00ebt\u00eb m\u00ebnyr\u00eb mund t\u00eb asistohet direkt n\u00eb t\u00eb gjitha fazat e tyre t\u00eb zhvillimit.<\/p>\n

Gjurmimi i k\u00ebtyre dallimeve<\/strong><\/p>\n

Hulumtuesit kan\u00eb marr\u00eb disa qeliza prej l\u00ebkur\u00ebs s\u00eb tet\u00eb personave autik\u00eb si dhe prej pes\u00eb individ\u00ebve t\u00eb tjer\u00eb t\u00eb paprekur prej k\u00ebtij sindromi. M\u00eb pas i kan\u00eb kthyer k\u00ebto qeliza n\u00eb gjendjen e qelizave staminale (burimore) p\u00ebrpara se t\u00eb stimulonin zhvillimin e tyre neuronal.<\/p>\n

Hulumtuesit mund\u00ebn t\u00eb nxjerrin informacione gjenetike prej k\u00ebtyre qelizave n\u00eb pes\u00eb momentet ky\u00e7e t\u00eb zhvillimit t\u00eb tyre, p\u00ebr t\u00eb zbuluar n\u00ebse kishte dallime n\u00eb mes t\u00eb dy grupeve.<\/p>\n

K\u00ebshtu, ekipi i studjuesve doli n\u00eb p\u00ebrfundimin se disa prej geneve t\u00eb nevojshme p\u00ebr formimin e neuroneve t\u00eb para, gene q\u00eb tashm\u00eb kishin qen\u00eb t\u00eb lidhura me autizmin n\u00eb studime t\u00eb m\u00ebparshme, aktivizoheshin m\u00eb par\u00eb tek njer\u00ebzit q\u00eb i kishin k\u00ebto \u00e7rregullime sesa tek njer\u00ebzit e grupit t\u00eb dyt\u00eb.<\/p>\n

Ky aktivizim i parakohsh\u00ebm i shtynte neuronet (qelizat nervore) t\u00eb zhvilloheshin m\u00eb shpejt, t\u00eb b\u00ebheshin m\u00eb t\u00eb m\u00ebdhaja dhe t\u00eb krijonin m\u00eb shum\u00eb lidhje me nj\u00ebra-tjetr\u00ebn.<\/p>\n

\u00c7udit\u00ebrisht, kur studiuesit i anashkalonin k\u00ebto faza t\u00eb hershme t\u00eb zhvillimit dhe prodhonin neurone drejtp\u00ebrs\u00ebdrejti nga qelizat e l\u00ebkur\u00ebs, pa kaluar m\u00eb par\u00eb n\u00ebp\u00ebrmjet qeliz\u00ebs staminale (burimore), diferencat gjenetike dhe fizike midis dy grupeve b\u00ebheshin t\u00eb pakapshme.<\/p>\n

Ky zbulim do t\u00eb thot\u00eb se, t\u00eb pakt\u00ebn n\u00eb disa raste, bazat e autizmit mund t\u00eb krijohen n\u00eb muajt e par\u00eb t\u00eb zhvillimit embrional.<\/p>\n

Edhe pse ky zbulim nuk mund t\u00eb aplikohet n\u00eb t\u00eb gjitha variantet e spektrit t\u00eb autizmit, ai mund t\u00eb \u00e7oj\u00eb n\u00eb nj\u00eb kuptim m\u00eb t\u00eb mir\u00eb t\u00eb disa prej shkaqeve, duke krijuar mund\u00ebsi t\u00eb reja p\u00ebr diagnostikimin e tyre si dhe objektiva t\u00eb mundshme p\u00ebr trajtimin e rasteve m\u00eb serioze.<\/p>\n","protected":false},"excerpt":{"rendered":"

(Publikuar nga Radio Canada dit\u00ebn e premte, m\u00eb 18 janar 2019) Qelizat staminale, p\u00ebr t\u00eb kuptuar zhvillimin e autizmit. Sipas nj\u00eb studimi t\u00eb fundit, sistemi nervor i njer\u00ebzve me spektrin e autizmit zhvillohet me nj\u00eb rit\u00ebm m\u00eb t\u00eb shpejt\u00eb. Autori : Renaud Manuguerra-Gagn\u00e9 P\u00ebrkthyer nga Edlira Dedja Duke p\u00ebrdorur nj\u00eb lloj t\u00eb ve\u00e7ant\u00eb qelizash staminale […]<\/p>\n","protected":false},"author":1,"featured_media":37525,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,38,36],"tags":[],"class_list":["post-37524","post","type-post","status-publish","format-standard","has-post-thumbnail","category-artikuj","category-kuriozitete","category-shkence"],"yoast_head":"\nT\u00eb rejat e fundit rreth zbulimeve shkencore n\u00eb fush\u00ebn e AUTIZMIT - FJALA e LIR\u00cb<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/jehonashqiptare.al\/fjala\/te-rejat-e-fundit-rreth-zbulimeve-shkencore-ne-fushen-e-autizmit\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"T\u00eb rejat e fundit rreth zbulimeve shkencore n\u00eb fush\u00ebn e AUTIZMIT - FJALA e LIR\u00cb\" \/>\n<meta property=\"og:description\" content=\"(Publikuar nga Radio Canada dit\u00ebn e premte, m\u00eb 18 janar 2019) Qelizat staminale, p\u00ebr t\u00eb kuptuar zhvillimin e autizmit. Sipas nj\u00eb studimi t\u00eb fundit, sistemi nervor i njer\u00ebzve me spektrin e autizmit zhvillohet me nj\u00eb rit\u00ebm m\u00eb t\u00eb shpejt\u00eb. 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Sipas nj\u00eb studimi t\u00eb fundit, sistemi nervor i njer\u00ebzve me spektrin e autizmit zhvillohet me nj\u00eb rit\u00ebm m\u00eb t\u00eb shpejt\u00eb. 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