{"id":53496,"date":"2020-04-08T13:54:48","date_gmt":"2020-04-08T12:54:48","guid":{"rendered":"https:\/\/fjala.info\/?p=53496"},"modified":"2020-04-08T13:56:56","modified_gmt":"2020-04-08T12:56:56","slug":"a-eshte-ky-ilac-arma-e-mrekullueshme","status":"publish","type":"post","link":"https:\/\/jehonashqiptare.al\/fjala\/a-eshte-ky-ilac-arma-e-mrekullueshme\/","title":{"rendered":"A \u00ebsht\u00eb ky ila\u00e7 arma e mrekullueshme?"},"content":{"rendered":"

OE24.at<\/strong><\/a>, 8 prill 2020<\/em><\/p>\n

TESTET INTENSIVE VAZHDOJN\u00cb<\/strong><\/span><\/p>\n

\n

Ila\u00e7i Remdesivir i Ebolas <\/strong>do t\u00eb p\u00ebrdoret tani gjithashtu p\u00ebr Covid-19.<\/p>\n<\/blockquote>\n

Nd\u00ebrsa shum\u00eb parime terapeutike ende t\u00eb paprovuara dhe substanca aktive po shfaqen rreth Covid-19<\/strong>, studime masive me remdesivir<\/strong> nga kompania farmaceutike amerikane Gilead<\/em> aktualisht jan\u00eb duke u zhvilluar. \u00cbsht\u00eb nj\u00eb ila\u00e7 “hetues”, me efekt potencialisht t\u00eb gjer\u00eb antiviral. Rezultate t\u00eb r\u00ebnd\u00ebsishme p\u00ebr pacient\u00ebt Covid-19 pritet s\u00eb shpejti.<\/p>\n

“Ne aktualisht jemi duke punuar me nj\u00eb shpejt\u00ebsi t\u00eb papar\u00eb, p\u00ebr t\u00eb p\u00ebrcaktuar sigurin\u00eb dhe efikasitetin (nga Remdesivir, Anm.) si nj\u00eb trajtim p\u00ebr Covid-19 dhe p\u00ebr t\u00eb rritur kapacitetin e prodhimit. M\u00eb shum\u00eb se 1.700 pacient\u00eb tashm\u00eb e kan\u00eb ila\u00e7in si pjes\u00eb e ‘Programit ton\u00eb t\u00eb m\u00ebshir\u00ebs’ (n\u00eb Austri: p\u00ebrpjekje individuale p\u00ebr sh\u00ebrim)<\/em>“, – sqaron kompania amerikane. Ila\u00e7i u p\u00ebrdor gjithashtu nga klinikat austriake n\u00eb baz\u00eb t\u00eb eksperimenteve individuale t\u00eb sh\u00ebrimit.<\/p>\n

Nukleotid <\/strong>Analog<\/strong><\/h3>\n

Substanca \u00ebsht\u00eb nj\u00eb e ashtuquajtur nukleotid analog<\/em>. \u00cbsht\u00eb e ngjashme me adenozin\u00ebn e komponentit gjenetik. SARS-CoV-2 gjithashtu k\u00ebrkon adenozin\u00eb p\u00ebr p\u00ebrs\u00ebritjen e materialit gjenetik t\u00eb tij ARN. Blloku i gabuar i nd\u00ebrtuar futet n\u00eb zinxhirin e materialit gjenetik dhe \u00e7on n\u00eb p\u00ebrfundimin e procesit. Kjo pengon p\u00ebrs\u00ebritjen e virusit. Parimi i veprimit \u00ebsht\u00eb i njohur q\u00eb nga zhvillimi i ila\u00e7eve t\u00eb para anti-HIV. Remdesivir<\/strong> thuhet se vepron relativisht gjer\u00ebsisht: p\u00ebr patogjen\u00ebt e etheve SARS, MERS-CoV, Ebola dhe Marburg. N\u00eb \u00e7do rast, para Covid-19, ajo u p\u00ebrdor n\u00eb pacient\u00ebt SARS-CoV dhe MERS-CoV. Nga modelet e kafsh\u00ebve (minj, majmun\u00eb) p\u00ebr infeksione t\u00eb virusit Ebola dhe Marburg. Ajo trajtoi m\u00eb shum\u00eb se 500 pacient\u00eb me s\u00ebmundje Ebola.<\/p>\n

Deri n\u00eb 25 Mars t\u00eb k\u00ebtij viti, shtat\u00eb pacient\u00eb t\u00eb rastit (t\u00eb caktuar rast\u00ebsisht n\u00eb grupe kontrolli) ishin regjistruar n\u00eb regjistrat nd\u00ebrkomb\u00ebtar\u00eb t\u00eb hulumtimeve klinike. Ata thuhet se p\u00ebrfshijn\u00eb rreth 5.600 pacient\u00eb t\u00eb shtruar n\u00eb Covid-19. Disa prej tyre jan\u00eb gjithashtu studime krahasuese me ila\u00e7e t\u00eb tjera potencialisht efektive, si\u00e7 jan\u00eb ritonavir<\/strong> \/ lopinavir<\/strong> (ila\u00e7 HIV \/ AIDS bazuar n\u00eb frenuesit e proteaz\u00ebs<\/em>) ose chloroquine<\/strong> (ila\u00e7 antik i malaries, i p\u00ebrdorur edhe p\u00ebr reumatiz\u00ebm<\/em>). K\u00ebto studime tashm\u00eb jan\u00eb duke u zhvilluar.<\/p>\n

Studimet e para<\/strong><\/h3>\n

Vet\u00eb Gilead organizoi dy t\u00eb ashtuquajtura gjykime t\u00eb thjeshta. P\u00ebr shembull, nj\u00eb studim p\u00ebrfshin 600 pacient\u00eb me s\u00ebmundje t\u00eb moderuar Covid-19. 200 prej pacient\u00ebve marrin Remdesivir<\/strong> p\u00ebr nj\u00eb gjat\u00ebsi t\u00eb ndryshme kohore, grupi i tret\u00eb trajtimi standard n\u00eb dispozicion ndryshe. Nj\u00eb studim i dyt\u00eb dhe i ngjash\u00ebm pa nj\u00eb grup kontrolli me thjesht\u00eb terapi standarde p\u00ebrfshin 400 pacient\u00eb me s\u00ebmundje t\u00eb r\u00ebnd\u00eb. Doza \u00ebsht\u00eb e nj\u00ebjt\u00eb, koh\u00ebzgjatja e trajtimit (si n\u00eb studimin e par\u00eb) \u00ebsht\u00eb pes\u00eb ose dhjet\u00eb dit\u00eb. N\u00eb total, megjithat\u00eb, mij\u00ebra pacient\u00eb p\u00ebrfundimisht do t\u00eb marrin pjes\u00eb n\u00eb programin e studimit.<\/p>\n

Aktualisht, ila\u00e7i zakonisht administrohet n\u00eb nj\u00eb doz\u00eb m\u00eb t\u00eb lart\u00eb fillestare p\u00ebrmes infuzionit n\u00eb dit\u00ebn e par\u00eb. Pastaj terapia (gjithashtu me an\u00eb t\u00eb infuzionit) b\u00ebhet n\u00eb nj\u00eb doz\u00eb m\u00eb t\u00eb ul\u00ebt.<\/p><\/blockquote>\n

Instituti Komb\u00ebtar i SHBA-ve me fam\u00eb bot\u00ebrore p\u00ebr infeksione dhe s\u00ebmundje alergjike (NIAID), i kryesuar nga Anthony Fauci, gjithashtu ka filluar nj\u00eb gjykim t\u00eb verb\u00ebr dhe t\u00eb kontrolluar nga placebo i remdesivir<\/strong>. Studime t\u00eb m\u00ebdha t\u00eb faz\u00ebs III mbi efektivitetin e drog\u00ebs n\u00eb pacient\u00ebt me Covid 19, me rrjedh\u00eb t\u00eb r\u00ebnd\u00eb ose t\u00eb moderuar t\u00eb s\u00ebmundjes, ekzistojn\u00eb n\u00eb Kin\u00eb me nj\u00eb total prej pothuajse 900 pacient\u00ebsh.<\/p>\n

Rezultatet q\u00eb priten s\u00eb shpejti<\/strong><\/h3>\n

Programi i zhvillimit klinik dhe vler\u00ebsimi i t\u00eb dh\u00ebnave nga 1.700 pacient\u00eb, q\u00eb kan\u00eb marr\u00eb tashm\u00eb ila\u00e7in duhet t\u00eb \u00e7ojn\u00eb n\u00eb deklaratat e para konkrete n\u00eb t\u00eb ardhmen e af\u00ebrt. Por kjo \u00ebsht\u00eb vet\u00ebm nj\u00eb pik\u00eb. N\u00ebse do t\u00eb ishte e suksesshme, kapacitetet e prodhimit p\u00ebr pandemin\u00eb do t\u00eb duhej t\u00eb rriteshin masivisht.<\/p>\n

Deri m\u00eb tani, procesi i prodhimit ka marr\u00eb n\u00ebnt\u00eb deri n\u00eb dymb\u00ebdhjet\u00eb muaj. Gilead aktualisht \u00ebsht\u00eb i mosh\u00ebs gjasht\u00eb deri n\u00eb tet\u00eb muaj. \u00cbsht\u00eb krijuar gjithashtu nj\u00eb rrjet nd\u00ebrkomb\u00ebtar i partner\u00ebve t\u00eb prodhimit n\u00eb Amerik\u00ebn e Veriut, Evrop\u00eb dhe Azi.<\/p>\n

Kompania amerikane ka shprehur gatishm\u00ebrin\u00eb e dor\u00ebzimit t\u00eb t\u00eb gjith\u00eb v\u00ebllimit aktual t\u00eb prodhimit t\u00eb Remdesivir<\/strong> falas. Kjo \u00ebsht\u00eb 1.5 milion kana\u00e7e. Me nj\u00eb koh\u00ebzgjatje mesatare t\u00eb vler\u00ebsuar t\u00eb trajtimit prej dhjet\u00eb dit\u00ebsh, ato jan\u00eb t\u00eb mjaftueshme p\u00ebr rreth 140,000 pacient\u00eb. Deri n\u00eb fund t\u00eb vitit, q\u00ebllimi \u00ebsht\u00eb t\u00eb krijojm\u00eb mund\u00ebsin\u00eb p\u00ebr t\u00eb prodhuar p\u00ebrb\u00ebr\u00ebs t\u00eb mjaftuesh\u00ebm aktiv\u00eb, p\u00ebr m\u00eb shum\u00eb se nj\u00eb milion cikle trajtimi.<\/p>\n","protected":false},"excerpt":{"rendered":"

OE24.at, 8 prill 2020 TESTET INTENSIVE VAZHDOJN\u00cb Ila\u00e7i Remdesivir i Ebolas do t\u00eb p\u00ebrdoret tani gjithashtu p\u00ebr Covid-19. Nd\u00ebrsa shum\u00eb parime terapeutike ende t\u00eb paprovuara dhe substanca aktive po shfaqen rreth Covid-19, studime masive me remdesivir nga kompania farmaceutike amerikane Gilead aktualisht jan\u00eb duke u zhvilluar. \u00cbsht\u00eb nj\u00eb ila\u00e7 “hetues”, me efekt potencialisht t\u00eb gjer\u00eb […]<\/p>\n","protected":false},"author":1,"featured_media":53497,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-53496","post","type-post","status-publish","format-standard","has-post-thumbnail","category-artikuj"],"yoast_head":"\nA \u00ebsht\u00eb ky ila\u00e7 arma e mrekullueshme? - FJALA e LIR\u00cb<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/jehonashqiptare.al\/fjala\/a-eshte-ky-ilac-arma-e-mrekullueshme\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A \u00ebsht\u00eb ky ila\u00e7 arma e mrekullueshme? - FJALA e LIR\u00cb\" \/>\n<meta property=\"og:description\" content=\"OE24.at, 8 prill 2020 TESTET INTENSIVE VAZHDOJN\u00cb Ila\u00e7i Remdesivir i Ebolas do t\u00eb p\u00ebrdoret tani gjithashtu p\u00ebr Covid-19. Nd\u00ebrsa shum\u00eb parime terapeutike ende t\u00eb paprovuara dhe substanca aktive po shfaqen rreth Covid-19, studime masive me remdesivir nga kompania farmaceutike amerikane Gilead aktualisht jan\u00eb duke u zhvilluar. \u00cbsht\u00eb nj\u00eb ila\u00e7 “hetues”, me efekt potencialisht t\u00eb gjer\u00eb […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/jehonashqiptare.al\/fjala\/a-eshte-ky-ilac-arma-e-mrekullueshme\/\" \/>\n<meta property=\"og:site_name\" content=\"FJALA e LIR\u00cb\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/facebook.com\/fjala.info\/\" \/>\n<meta property=\"article:author\" content=\"https:\/\/facebook.com\/shkoder.net\/\" \/>\n<meta property=\"article:published_time\" content=\"2020-04-08T12:54:48+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-04-08T12:56:56+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/jehonashqiptare.al\/fjala\/wp-content\/uploads\/2020\/04\/coronavirus-ebola.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"640\" \/>\n\t<meta property=\"og:image:height\" content=\"360\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@https:\/\/twitter.com\/acokaj\" \/>\n<meta name=\"twitter:site\" content=\"@acokaj\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/jehonashqiptare.al\\\/fjala\\\/a-eshte-ky-ilac-arma-e-mrekullueshme\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/jehonashqiptare.al\\\/fjala\\\/a-eshte-ky-ilac-arma-e-mrekullueshme\\\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\\\/\\\/jehonashqiptare.al\\\/fjala\\\/#\\\/schema\\\/person\\\/9c9fccf4f6449d25e258607d9b4275cb\"},\"headline\":\"A \u00ebsht\u00eb ky ila\u00e7 arma e mrekullueshme?\",\"datePublished\":\"2020-04-08T12:54:48+00:00\",\"dateModified\":\"2020-04-08T12:56:56+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/jehonashqiptare.al\\\/fjala\\\/a-eshte-ky-ilac-arma-e-mrekullueshme\\\/\"},\"wordCount\":794,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/jehonashqiptare.al\\\/fjala\\\/a-eshte-ky-ilac-arma-e-mrekullueshme\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/jehonashqiptare.al\\\/fjala\\\/wp-content\\\/uploads\\\/2020\\\/04\\\/coronavirus-ebola.jpg\",\"articleSection\":[\"Artikuj\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/jehonashqiptare.al\\\/fjala\\\/a-eshte-ky-ilac-arma-e-mrekullueshme\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/jehonashqiptare.al\\\/fjala\\\/a-eshte-ky-ilac-arma-e-mrekullueshme\\\/\",\"url\":\"https:\\\/\\\/jehonashqiptare.al\\\/fjala\\\/a-eshte-ky-ilac-arma-e-mrekullueshme\\\/\",\"name\":\"A \u00ebsht\u00eb ky ila\u00e7 arma e mrekullueshme? 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