{"id":74646,"date":"2021-12-19T22:48:42","date_gmt":"2021-12-19T21:48:42","guid":{"rendered":"https:\/\/fjala.info\/?p=74646"},"modified":"2021-12-19T22:48:42","modified_gmt":"2021-12-19T21:48:42","slug":"ugur-sahin-dhe-ozlem-tureci-per-te-ardhmen-e-terapive-mrna","status":"publish","type":"post","link":"https:\/\/jehonashqiptare.al\/fjala\/ugur-sahin-dhe-ozlem-tureci-per-te-ardhmen-e-terapive-mrna\/","title":{"rendered":"Ugur Sahin dhe Ozlem Tureci p\u00ebr t\u00eb ardhmen e terapive mRNA"},"content":{"rendered":"

Themeluesit e BioNTech po shikojn\u00eb p\u00ebrtej Covid-19<\/p><\/blockquote>\n

Bota drejt 2022<\/em><\/h3>\n

The Economist<\/a> – NGA UGUR SAHIN<\/strong> DHE OZLEM TURECI<\/strong>: FOUNDERS OF BIONTECH<\/p>\n

P\u00ebrktheu Arben \u00c7okaj<\/a><\/em><\/p>\n

Zhvillimi i shpejt\u00eb i vaksinave t\u00eb shumta kund\u00ebr Covid-19 \u00ebsht\u00eb nj\u00eb arritje e paprecedent\u00eb n\u00eb zhvillimin e ila\u00e7eve, q\u00eb ka ofruar nj\u00eb rrug\u00ebdalje nga pandemia. Por ka m\u00eb shum\u00eb lajme t\u00eb mira p\u00ebr t\u00eb ardhur. Roli i vaksinave t\u00eb bazuara n\u00eb teknologjin\u00eb mesazher RNA (mRNA) n\u00eb k\u00ebt\u00eb sukses, paralajm\u00ebron nj\u00eb epok\u00eb t\u00eb re n\u00eb zhvillimin e terapive p\u00ebr s\u00ebmundje t\u00eb tjera.<\/p>\n

Zbulimi i mRNA u b\u00eb i mundur nga bashk\u00ebpunimi shkencor gjat\u00eb tre dekadave, q\u00eb ndihmoi n\u00eb transformimin e nj\u00eb koncepti premtues, n\u00eb nj\u00eb platform\u00eb biofarmaceutike shum\u00eb t\u00eb fuqishme dhe t\u00eb gjithanshme. Ne besojm\u00eb se n\u00eb 15 vjet, nj\u00eb e treta e t\u00eb gjitha barnave t\u00eb miratuara rishtazi do t\u00eb bazohet n\u00eb mRNA.<\/p>\n

N\u00eb vend q\u00eb t\u00eb mb\u00ebshteten n\u00eb procese fermentimi komplekse dhe q\u00eb k\u00ebrkojn\u00eb koh\u00eb p\u00ebr t\u00eb prodhuar ila\u00e7e, terapit\u00eb mRNA i kthejn\u00eb qelizat e vet\u00eb marr\u00ebsit n\u00eb fabrika t\u00eb barnave. \u00c7do molekul\u00eb mRNA \u00ebsht\u00eb nj\u00eb recet\u00eb q\u00eb udh\u00ebzon qelizat t\u00eb prodhojn\u00eb nj\u00eb protein\u00eb specifike t\u00eb d\u00ebshiruar. Vaksina jon\u00eb kund\u00ebr Covid-19 i shtyn qelizat t\u00eb prodhojn\u00eb protein\u00ebn “spike<\/em>“, q\u00eb gjendet n\u00eb veshjen e jashtme t\u00eb koronavirusit, duke nxitur k\u00ebshtu sistemin imunitar, n\u00eb m\u00ebnyr\u00eb q\u00eb m\u00eb pas t\u00eb mund t\u00eb njoh\u00eb dhe t\u00eb mbrohet nga virusi.<\/p>\n

Kjo teknologji \u00ebsht\u00eb nj\u00eb pik\u00eb kthese n\u00eb industrin\u00eb farmaceutike, e krahasueshme me inaugurimin e teknologjis\u00eb s\u00eb ADN-s\u00eb rekombinante (q\u00eb lejon prodhimin e barnave me proteina njer\u00ebzore si insulina), ose antitrupave monoklonale n\u00eb fermentuesit laboratorik\u00eb, m\u00eb shum\u00eb se 40 vjet m\u00eb par\u00eb. P\u00ebrhapja e k\u00ebtij koncepti n\u00eb barna leht\u00ebsisht t\u00eb disponueshme premton t\u00eb prish\u00eb dhe transformoj\u00eb industrin\u00eb – dhe sh\u00ebndetin global.<\/p>\n

Ne besojm\u00eb se n\u00eb 15 vjet, nj\u00eb e treta e t\u00eb gjitha barnave t\u00eb miratuara rishtazi do t\u00eb bazohen n\u00eb mRNA<\/p><\/blockquote>\n

Zhvillimi i vaksinave kund\u00ebr Covid-19, t\u00eb bazuara n\u00eb mRNA ka v\u00ebrtetuar efikasitetin dhe sigurin\u00eb e k\u00ebsaj qasjeje n\u00eb parandalimin e s\u00ebmundjeve infektive. Fakti q\u00eb nj\u00eb vaksin\u00eb e sigurt dhe efektive mund t\u00eb zhvillohet n\u00eb m\u00eb pak se 12 muaj, n\u00eb mes t\u00eb nj\u00eb pandemie, dhe m\u00eb pas t\u00eb prodhohet n\u00eb shkall\u00eb, sugjeron q\u00eb vaksinat mRNA do t\u00eb luajn\u00eb nj\u00eb rol t\u00eb r\u00ebnd\u00ebsish\u00ebm n\u00eb programet e ardhshme t\u00eb gatishm\u00ebris\u00eb ndaj pandemis\u00eb, t\u00eb cilat jan\u00eb axhendat e larta t\u00eb qeverive.<\/p>\n

Ai gjithashtu hap rrug\u00ebn q\u00eb vaksinat mRNA t\u00eb vendosen kund\u00ebr s\u00ebmundjeve t\u00eb tjera infektive. Shum\u00eb vaksina ekzistuese p\u00ebr s\u00ebmundje t\u00eb tilla mund t\u00eb riformulohen duke p\u00ebrdorur mRNA, duke i b\u00ebr\u00eb ato m\u00eb efikase. Ne besojm\u00eb se shkatht\u00ebsia e teknologjis\u00eb mRNA ofron mund\u00ebsi p\u00ebr t\u00eb shkuar m\u00eb tej dhe p\u00ebr t\u00eb luftuar s\u00ebmundjet aktualisht t\u00eb pamposhtura.<\/p>\n

N\u00eb BioNTech, ne tani po shkojm\u00eb p\u00ebrtej Covid-19 dhe po investojm\u00eb n\u00eb programet e vaksin\u00ebs mRNA, p\u00ebr t’u marr\u00eb me s\u00ebmundje t\u00eb tilla si malaria, tuberkulozi dhe HIV, t\u00eb cilat jan\u00eb ende p\u00ebrgjegj\u00ebse p\u00ebr shum\u00eb vdekje n\u00eb vendet me t\u00eb ardhura m\u00eb t\u00eb ul\u00ebta. Perspektiva p\u00ebr t\u00eb qen\u00eb n\u00eb gjendje t\u00eb sjell\u00eb teknologjin\u00eb mRNA, po krijon nj\u00eb frym\u00eb optimizmi n\u00eb luft\u00ebn kund\u00ebr k\u00ebtyre plag\u00ebve njer\u00ebzore.<\/p>\n

Pandemia i ka detyruar njer\u00ebzit t\u00eb punojn\u00eb m\u00eb mir\u00eb s\u00eb bashku. Projektet e nisura s\u00eb fundmi kan\u00eb par\u00eb nj\u00eb shkall\u00eb t\u00eb lart\u00eb bashk\u00ebpunimi midis institucioneve si Organizata Bot\u00ebrore e Sh\u00ebndet\u00ebsis\u00eb, autoriteteve rregullatore nd\u00ebrkomb\u00ebtare dhe organizatave financuese, t\u00eb mb\u00ebshtetura nga ekspert\u00eb q\u00eb kan\u00eb hulumtuar patogjen\u00ebt me interes p\u00ebr m\u00eb shum\u00eb se 30 vjet. Kandidat\u00ebt e par\u00eb t\u00eb vaksin\u00ebs mRNA p\u00ebr k\u00ebto s\u00ebmundje, pritet t\u00eb hyjn\u00eb n\u00eb provat klinike n\u00eb 2022 dhe 2023.<\/p>\n

Ne gjithashtu p\u00ebrballemi me probleme sh\u00ebndet\u00ebsore gjithnj\u00eb e m\u00eb sfiduese n\u00eb shkall\u00eb globale, si s\u00ebmundjet e lidhura me mosh\u00ebn n\u00eb vendet e zhvilluara dhe nevoj\u00ebn n\u00eb rritje p\u00ebr kujdes par\u00ebsor sh\u00ebndet\u00ebsor t\u00eb p\u00ebrballuesh\u00ebm n\u00eb vendet me t\u00eb ardhura t\u00eb ul\u00ebta. K\u00ebto mund t\u00eb mposhten vet\u00ebm me inovacion t\u00eb q\u00ebndruesh\u00ebm, q\u00eb \u00ebsht\u00eb i gjithansh\u00ebm dhe me kosto efikase dhe mund t\u00eb mund\u00ebsoj\u00eb individualizimin e trajtimit dhe sh\u00ebnjestrimin e s\u00ebmundjeve t\u00eb rralla. Ne besojm\u00eb se k\u00ebto nevoja mund t\u00eb adresohen n\u00eb m\u00ebnyr\u00eb t\u00eb p\u00ebrsosur nga mRNA.<\/p>\n

Kutia e pasur e mjeteve t\u00eb teknologjive mRNA p\u00ebrfshin nj\u00eb portofol gjithnj\u00eb e m\u00eb t\u00eb larmish\u00ebm t\u00eb formateve mRNA, disa me aft\u00ebsin\u00eb p\u00ebr t’u shumuar n\u00eb qeliza, dhe nj\u00eb mori m\u00ebnyrash p\u00ebr t\u00eb shp\u00ebrndar\u00eb mRNA n\u00eb organe dhe qeliza t\u00eb ndryshme n\u00eb trup. N\u00eb t\u00eb ardhmen, ila\u00e7et mRNA mund t\u00eb p\u00ebrdoren p\u00ebr terapi t\u00eb individualizuara t\u00eb kancerit, mjek\u00ebsi rigjeneruese dhe p\u00ebr nj\u00eb shum\u00ebllojshm\u00ebri t\u00eb gjer\u00eb s\u00ebmundjesh si alergjit\u00eb, kushtet autoimune dhe s\u00ebmundjet inflamatore.<\/p>\n

\u00c7far\u00eb b\u00ebri mARN m\u00eb pas<\/strong><\/h3>\n

Skena \u00ebsht\u00eb vendosur p\u00ebr shfaqjen e nj\u00eb industrie t\u00eb re t\u00eb teknologjis\u00eb sh\u00ebndet\u00ebsore, q\u00eb do t\u00eb rip\u00ebrcaktoj\u00eb peizazhin biotekno-farmaceutik. Nj\u00eb mund\u00ebsues ky\u00e7 i suksesit do t\u00eb jet\u00eb, q\u00eb drejtuesit dhe pionier\u00ebt e teknologjis\u00eb sh\u00ebndet\u00ebsore t\u00eb mir\u00ebpresin dhe mb\u00ebshtesin p\u00ebr\u00e7ar\u00ebsit e rinj n\u00eb treg. Vet\u00ebm duke inkurajuar m\u00eb tej investimet n\u00eb inovacion dhe duke nxitur nj\u00eb kultur\u00eb bashk\u00ebpunimi dhe fekondimi t\u00eb kryq\u00ebzuar, kjo industri e re do t\u00eb b\u00ebhet nj\u00eb ndryshim p\u00ebr sh\u00ebndetin publik. Kjo gjenerat\u00eb e re lojtar\u00ebsh t\u00eb farmaceutik\u00ebs mund t\u00eb riform\u00ebsoj\u00eb sh\u00ebndetin e bot\u00ebs n\u00eb vitin 2022 \u2014 dhe m\u00eb tej.<\/p>\n

Ugur Shahin dhe Ozlem Tureci: themeluesit e BioNTech<\/em> \u25a0<\/span><\/p>\n

Ky artikull u shfaq n\u00eb seksionin e Shkenc\u00ebs dhe Teknologjis\u00eb t\u00eb edicionit t\u00eb printuar t\u00eb The World Ahead 2022 n\u00ebn titullin “E ardhmja post-covid e terapive mRNA”<\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":"

Themeluesit e BioNTech po shikojn\u00eb p\u00ebrtej Covid-19 Bota drejt 2022 The Economist – NGA UGUR SAHIN DHE OZLEM TURECI: FOUNDERS OF BIONTECH P\u00ebrktheu Arben \u00c7okaj Zhvillimi i shpejt\u00eb i vaksinave t\u00eb shumta kund\u00ebr Covid-19 \u00ebsht\u00eb nj\u00eb arritje e paprecedent\u00eb n\u00eb zhvillimin e ila\u00e7eve, q\u00eb ka ofruar nj\u00eb rrug\u00ebdalje nga pandemia. Por ka m\u00eb shum\u00eb lajme […]<\/p>\n","protected":false},"author":1,"featured_media":74647,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,173],"tags":[],"class_list":["post-74646","post","type-post","status-publish","format-standard","has-post-thumbnail","category-artikuj","category-covid-19"],"yoast_head":"\nUgur Sahin dhe Ozlem Tureci p\u00ebr t\u00eb ardhmen e terapive mRNA - FJALA e LIR\u00cb<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/jehonashqiptare.al\/fjala\/ugur-sahin-dhe-ozlem-tureci-per-te-ardhmen-e-terapive-mrna\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ugur Sahin dhe Ozlem Tureci p\u00ebr t\u00eb ardhmen e terapive mRNA - FJALA e LIR\u00cb\" \/>\n<meta property=\"og:description\" content=\"Themeluesit e BioNTech po shikojn\u00eb p\u00ebrtej Covid-19 Bota drejt 2022 The Economist – NGA UGUR SAHIN DHE OZLEM TURECI: FOUNDERS OF BIONTECH P\u00ebrktheu Arben \u00c7okaj Zhvillimi i shpejt\u00eb i vaksinave t\u00eb shumta kund\u00ebr Covid-19 \u00ebsht\u00eb nj\u00eb arritje e paprecedent\u00eb n\u00eb zhvillimin e ila\u00e7eve, q\u00eb ka ofruar nj\u00eb rrug\u00ebdalje nga pandemia. 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